http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Priya Desai (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Incretin Hormones: Pathophysiological Risk Factors and Potential Targets for Type 2 Diabetes
Jared Rosenberg,Jordan Jacob,Priya Desai,Jeremy Park,Lorin Donovan,김준영 대한비만학회 2021 The Korean journal of obesity Vol.30 No.3
Type 2 diabetes (T2D) is a multifaceted metabolic disorder associated with distinctive pathophysiological disturbances. One of the pathophysiological risk factors observed in T2D is dysregulation of the incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Both hormones stimulate insulin secretion by acting postprandially on pancreatic β-cell receptors. Oral glucose administration stimulates increased insulin secretion in comparison with isoglycemic intravenous glucose administration, a phenomenon known as the incretin effect. While the evidence for incretin defects in individuals with T2D is growing, the etiology behind this attenuated incretin effect in T2D is not clearly understood. Given their central role in T2D pathophysiology, incretins are promising targets for T2D therapeutics. The present review synthesizes the recent attempts to explain the biological importance of incretin hormones and explore potential pharmacological approaches that target the incretins.
-
Vegetarian ethnic foods of South India: review on the influence of traditional knowledge
Parthasarathi Srinidhi K.,Hebbani Ananda Vardhan,Dharmavaram Desai Padma Priya 한국식품연구원 2022 Journal of Ethnic Foods Vol.9 No.-
South Indian cultures are diverse and unique amongst Indian traditions. In spite of many changes in Indian traditions over generations, South Indian states seem to have maintained a great extent of similarity with reference to vegetarian ethnic food habits and the reason behind is not convincingly known. Hindu traditional texts have extensive mention of the ethnic origins of many cultural practices prevailing in India and the present review aims to explore the different vegetarian ethnic foods of South India and also look into the influential role of food related ideologies mentioned in the traditional texts. Ethnographic study data about the prevailing vegetarian foods of the states were generated using multiple tools and presented. It is observed that there is a great extent of similarity amongst the varieties of vegetarian foods being prepared in Hindu communities of South India. Our study also highlights the strong influential role of tradition in evolution of vegetarian foods prevailing even today in South India.
-
아나볼릭 스테로이드, 선택적 아드로겐 수용체 조절인자, 그리고 마이오스타틴 억제제의 기전에 관한 연구
Jeremy Park,Vera Mcllvain,Jared Rosenberg,Lorin Donovan,Priya Desai,김준영 대한스포츠의학회 2022 대한스포츠의학회지 Vol.40 No.2
In the clinical setting, anabolic agents serve to ameliorate muscle- and bone-wasting diseases. However, many of these anabolic agents are also used by bodybuilders to surpass natural limits of body composition as performance- enhancing drugs (PEDs). The first generation of PEDs comprises testosterone-derived anabolic-androgenic steroids (AAS) which have demonstrated significant myotropic effects. However, AAS lack optimal tissue-selectively and thus, are prone to numerous adverse health consequences. Hence, a newer generation of PEDs, selective androgen receptor modulators (SARMs), was developed with the goal of achieving superior tissue-selectivity (i.e., exerting anabolic effects only in muscle and bone tissue, while minimally affecting other body systems). In general, AAS and SARMs enhance muscle growth primarily through androgen receptor (AR) agonism in target tissues. Despite multiple attempts, no single AAS nor SARM to date is completely risk free. As such, a significant portion of research efforts has been dedicated to manipulating anabolic pathways beyond the AR. Another class of PEDs, myostatin inhibitors, have shown to cause drastic muscle anabolism across multiple species by inhibiting myostatin, the primary deterrent to continuous muscle growth. The myostatin inhibitor, YK-11, blocks myostatin by upregulating its antagonist, follistatin. This effect appears to be mediated through the AR, suggesting a novel and promising gene-selective approach to engineering AR ligands that isolate benefits from risks. At any rate, the exact mechanisms by which these PEDs function is not well understood. Further pioneering regarding these topics is encouraged as it appears that the innovation of a truly tissue-selective anabolic agent is within reach.
-
Jeremy Park,Vera Mcllvain,Jared Rosenberg,Lorin Donovan,Priya Desai,김준영 대한스포츠의학회 2022 대한스포츠의학회지 Vol.40 No.3
A complex network of biochemical pathways carries out the process of muscle regeneration/growth followingresistance exercise. The initial inflammatory response following muscle damage is primarily mediated by the nuclearfactor κ-light-chain-enhancer of activated B cells (NF-κB), cyclooxygenase enzymes, and prostaglandins. Muscledamage also stimulates the activation, proliferation, differentiation, migration, and fusion of satellite cells ontodamaged myofibers, resulting in myofibrillar hypertrophy. The progression of the myogenic lineage is predominantlycoordinated by the wingless/integrated family of glycoproteins which engages in crosstalk with NF-κB and themitogen-activated protein kinase (MAPK)/extracellular signaling-regulated kinase network. The MAPK cascade isessential for mechanotransduction, the process of converting mechanical stimuli into biochemical responses suchas accelerated protein synthesis and satellite cell activation. Muscle protein synthesis is primarily governed by theinsulin-like growth factor 1/phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathway. Several calcium-dependent pathways are also integrated into the process of myogenesis and influence skeletalmuscle plasticity. These dynamic interactions are part of the anabolic priming by resistance exercise effect, whichdefines resistance exercise as an acute catabolic event that potentiates multiple downstream anabolic pathways. Plateaus in muscle growth are attributed to deteriorating inflammatory signaling with repeated bouts of muscledamage as well as increasing thresholds for continuous adaptations, which ultimately become unreachable beyonda certain point. The physiological ceiling of skeletal muscle mass is also credited to myostatin. However, recentdiscoveries suggest the role of myostatin is not limited to preventing excessive skeletal muscle hypertrophy
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
