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Pradelle-Plasse Nelly,Mocquot Caroline,Semennikova Katherine,Colon Pierre,Grosgogeat Brigitte 대한치과보존학회 2021 Restorative Dentistry & Endodontics Vol.46 No.1
Objectives: This study aimed to evaluate the interface between a calcium silicate cement (CSC), Biodentine and dental adhesives in terms of sealing ability. Materials and Methods: Microleakage test: 160 standardized class II cavities were prepared on 80 extracted human molars. The cavities were filled with Biodentine and then divided into 2 experimental groups according to the time of restoration: composite resin obturation 15 minutes after Biodentine handling (D0); restoration after 7 days (D7). Each group was then divided into 8 subgroups (n = 5) according to the adhesive system used: etch-and-rinse adhesive (Prime & Bond); self-etch adhesive 2 steps (Optibond XTR and Clearfil SE Bond); self-etch adhesive 1 step (Xeno III, G-aenial Bond, and Clearfil Tri-S Bond); and universal used as etch-and-rinse or self-etch (ScotchBond Universal ER or SE). After thermocycling, the teeth were immersed in a silver nitrate solution, stained, longitudinally sectioned, and the Biodentine/adhesive percolation was quantified. Scanning electron microscopic observations: Biodentine/adhesive interfaces were observed. Results: A tendency towards less microleakage was observed when Biodentine was etched (2.47%) and when restorations were done without delay (D0: 4.31%, D7: 6.78%), but this was not significant. The adhesives containing 10-methacryloyloxydecyl dihydrogen phosphate monomer showed the most stable results at both times studied. All Biodentine/adhesive interfaces were homogeneous and regular. Conclusions: The good sealing of the CSC/adhesive interface is not a function of the system adhesive family used or the cement maturation before restoration. Biodentine can be used as a dentine substitute.
PRC2 loss amplifies Ras signaling in cancer
Baude, Annika,Lindroth, Anders M,Plass, Christoph Nature Pub. Co 2014 Nature genetics Vol.46 No.11
The histone-modifying PRC2 complex has an ambiguous role in cancer, bearing both oncogenic and tumor-suppressive features depending on cell type. Studies of malignant peripheral nerve sheath tumors (MPNSTs) have now identified loss-of-function mutations altering PRC2 subunits, leading to the amplification of Ras-driven transcription and conferring vulnerability to BRD4 inhibitors.
Yoo, Y,Park, J H,Weigel, C,Liesenfeld, D B,Weichenhan, D,Plass, C,Seo, D-G,Lindroth, A M,Park, Y J Nature Publishing Group 2017 International Journal of Obesity Vol.41 No.4
<P>CONCLUSIONS: TET proteins, particularly TET2, were required for adipogenesis by modulating DNA methylation at the Ppar. locus, subsequently by inducing Ppar. gene expression.</P>
Custodian-based information sharing
Jacobson, V.,Braynard, R. L.,Diebert, T.,Mahadevan, P.,Mosko, M.,Briggs, N. H.,Barber, S.,Plass, M. F.,Solis, I.,Uzun, E.,Byoung-Joon Lee,Myeong-Wuk Jang,Dojun Byun,Smetters, D. K.,Thornton, J. D. IEEE 2012 IEEE communications magazine Vol.50 No.7
<P>Information sharing systems such as iCloud, Dropbox, Facebook, and Twitter are ubiquitous today, but all of them depend on massive server infrastructure and always-on Internet connectivity. We have designed and implemented a sharing system that does not require infrastructure yet supports robust, distributed, secure sharing by opportunistically using any and all connectivity, local or global, permanent or transient, to communicate. One key element of this system is a new information routing model that so far has proven to be as scalable and efficient as the best of the current Internet routing protocols, while operating in an environment more complex and dynamic than they can tolerate. The new routing model is made possible by new affordances offered by information-centric networking, in particular, the open source CCN [1] release. This article describes the new system and its routing model, and provides some performance measurements.</P>
Johannes Hausmann,Andrea Tal,Artur Gomer,Michael Philipper,Gero Moog,Horst Hohn,Norbert Hesselbarth,Harald Plass,Jörg Albert,Fabian Finkelmeier 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.1
Background/Aims: Reliable and especially widely accepted preventive measures are crucial to further reduce the incidenceof colorectal cancer (CRC). Colon capsule endoscopy (CCE) might increase the screening numbers among patients unable orunwilling to undergo conventional colonoscopy. This registry trial aimed to document and determine the CCE indications, findings,complications, and adverse events in outpatient practices and clinics throughout Germany. Methods: Patients undergoing CCE between 2010 and 2015 were enrolled in this prospective multicenter registry trial at six Germancenters. Patient demographics, outcomes, and complications were evaluated. Results: A total of 161 patients were included. Of the CCE evaluations, 111 (68.9%) were considered successful. Pathological findingsin the colon (n=92, 60.1%) and in the remaining gastrointestinal tract (n=38, 24.8%) were recorded. The main finding was thepresence of polyps (n=52, 32.3%). Furthermore, five carcinomas (3.1%) were detected and histologically confirmed later. Adequatebowel cleanliness was more likely to be achieved in the outpatient setting (p<0.0001). Interestingly, 85 patients (55.6%) chose toundergo CCE based on personal motivation. Conclusions: CCE seems to be a reliable and safe endoscopic tool for screening for CRC and detecting other diseases. Its patientacceptance and feasibility seems to be high, especially in the outpatient setting.
Arab, K.,Park, Y.,Lindroth, Anders M.,Schafer, A.,Oakes, C.,Weichenhan, D.,Lukanova, A.,Lundin, E.,Risch, A.,Meister, M.,Dienemann, H.,Dyckhoff, G.,Herold-Mende, C.,Grummt, I.,Niehrs, C.,Plass, C. Cell Press 2014 Molecular cell Vol.55 No.4
DNA methylation is a dynamic and reversible process that governs gene expression during development and disease. Several examples of active DNA demethylation have been documented, involving genome-wide and gene-specific DNA demethylation. How demethylating enzymes are targeted to specific genomic loci remains largely unknown. We show that an antisense lncRNA, termed TARID (for TCF21 antisense RNA inducing demethylation), activates TCF21 expression by inducing promoter demethylation. TARID interacts with both the TCF21 promoter and GADD45A (growth arrest and DNA-damage-inducible, alpha), a regulator of DNA demethylation. GADD45A in turn recruits thymine-DNA glycosylase for base excision repair-mediated demethylation involving oxidation of 5-methylcytosine to 5-hydroxymethylcytosine in the TCF21 promoter by ten-eleven translocation methylcytosine dioxygenase proteins. The results reveal a function of lncRNAs, serving as a genomic address label for GADD45A-mediated demethylation of specific target genes.