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- 저자 : Pierre Dupont (검색결과 5 건)
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Immunomodulation by a Malleable Matrix Composed of Fermented Whey Proteins and Lactic Acid Bacteria
Pierre Lemieux,Josoe Beaulieu,Roger Dubuc,Nicolas Beaudet,Claude Dupont 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.1
Functional foods and nutraceuticals have gained in popularity over the last 10 years. Among natural healthproducts, whey proteins and fermented milk products are paramount. A malleable protein matrix (MPM), composed of wheyfermented by a lactic acid bacterium, capsular exopolysaccharides, vitamins, minerals, and peptides generated during the fer-mentation process, has the potential to be unique by combining multiple health-promoting components. Forced feeding ex-periments on healthy animals were performed to evaluate the immunomodulatory effect of MPM. Glutathione production, an-consumption was evident as seen by the increased polymorphonuclear cell counts and intracellular glutathione levels. The ab-sence of MPM-specific antibody production indicated a lack of undesirable immune recognition of MPM. The MPM, with itsimmunomodulatory properties, has the potential to be a food substitute or a functional food for maintenance of general im-mune health.
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Dupont Vincent,Blanc Victor,Beck Thierry,Lainet Marc,Sciora Pierre 한국원자력학회 2024 Nuclear Engineering and Technology Vol.56 No.3
In the framework of the Generation IV research and development project, in which the French Commission of Alternative and Atomic Energies (CEA) is involved, a main objective for the design of Sodium-cooled Fast Reactor (SFR) is to meet the safety goals for severe accidents. Among the severe ones, the Unprotected Transient OverPower (UTOP) accidents can lead very quickly to a global melting of the core. UTOP accidents can be considered either as slow during a Control Rod Withdrawal (CRW) or as fast. The paper focuses on fast UTOP accidents, which occur in a few milliseconds, and three different scenarios are considered: rupture of the core support plate, uncontrolled passage of a gas bubble inside the core and core mechanical distortion such as a core flowering/compaction during an earthquake. Several levels and rates of reactivity insertions are also considered and the thermal-mechanical behavior of an ASTRID fuel pin from the ASTRID CFV core is simulated with the GERMINAL code. Two types of fuel pins are simulated, inner and outer core pins, and three different burn-up are considered. Moreover, the feedback from the CABRI programs on these type of transients is used in order to evaluate the failure mechanism in terms of kinetics of energy injection and fuel melting. The CABRI experiments complete the analysis made with GERMINAL calculations and have shown that three dominant mechanisms can be considered as responsible for pin failure or onset of pin degradation during ULOF/UTOP accident: molten cavity pressure loading, fuel-cladding mechanical interaction (FCMI) and fuel break-up. The study is one of the first step in fast UTOP accidents modelling with GERMINAL and it has shown that the code can already succeed in modelling these type of scenarios up to the sodium boiling point. The modeling of the radial propagation of the melting front, validated by comparison with CABRI tests, is already very efficient.
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Optimizing Tube Precurvature to Enhance the Elastic Stability of Concentric Tube Robots
Ha, Junhyoung,Park, Frank C.,Dupont, Pierre E. IEEE 2017 IEEE transactions on robotics Vol.33 No.1
<P>Robotic instruments based on concentric tube technology are well suited to minimally invasive surgery since they are slender, can navigate inside small cavities, and can reach around sensitive tissues by taking on shapes of varying curvatures. Elastic instabilities can arise, however, when rotating one precurved tube inside another. In contrast to prior work that considered only tubes of piecewise constant precurvature, we allow precurvature to vary along the tube's arc length. Stability conditions for a planar tube pair are derived and used to formulate an optimal design problem. An analytic formulation of the optimal precurvature function is derived, which achieves a desired tip orientation range while maximizing stability and respecting bending strain limits. This formulation also includes straight transmission segments at the proximal ends of the tubes. The result, confirmed by both numerical and physical experiment, enables designs with enhanced stability in comparison to designs of constant precurvature.</P>
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Elastic Stability of Concentric Tube Robots Subject to External Loads
Ha, Junhyoung,Park, Frank C.,Dupont, Pierre E. IEEE 2016 IEEE Transactions on Biomedical Engineering Vol.63 No.6
<P>Concentric tube robots, which are comprised of precurved elastic tubes that are concentrically arranged, are being developed for many medical interventions. The shape of the robot is determined by the rotation and translation of the tubes relative to each other, and also by any external forces applied by the environment. As the tubes rotate and translate relative to each other, elastic potential energy caused by tube bending and twisting can accumulate; if a configuration is not locally elastically stable, then a dangerous snapping motion may occur as energy is suddenly released. External loads on the robot also influence elastic stability. In this paper, we provide a second-order sufficient condition, and also a separate necessary condition, for elastic stability. Using methods of optimal control theory, we show that these conditions apply to general concentric tube robot designs subject to arbitrary conservative external loads. They can be used to assess the stability of candidate robot configurations. Our results are validated via comparison with other known stability criteria, and their utility is demonstrated by an application to stable path planning.</P>
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