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Applications of Chondrocyte-Based Cartilage Engineering: An Overview
Phull, Abdul-Rehman,Eo, Seong-Hui,Abbas, Qamar,Ahmed, Madiha,Kim, Song Ja Hindawi Publishing Corporation 2016 BioMed research international Vol.2016 No.-
<P>Chondrocytes are the exclusive cells residing in cartilage and maintain the functionality of cartilage tissue. Series of biocomponents such as different growth factors, cytokines, and transcriptional factors regulate the mesenchymal stem cells (MSCs) differentiation to chondrocytes. The number of chondrocytes and dedifferentiation are the key limitations in subsequent clinical application of the chondrocytes. Different culture methods are being developed to overcome such issues. Using tissue engineering and cell based approaches, chondrocytes offer prominent therapeutic option specifically in orthopedics for cartilage repair and to treat ailments such as tracheal defects, facial reconstruction, and urinary incontinence. Matrix-assisted autologous chondrocyte transplantation/implantation is an improved version of traditional autologous chondrocyte transplantation (ACT) method. An increasing number of studies show the clinical significance of this technique for the chondral lesions treatment. Literature survey was carried out to address clinical and functional findings by using various ACT procedures. The current study was conducted to study the pharmacological significance and biomedical application of chondrocytes. Furthermore, it is inferred from the present study that long term follow-up studies are required to evaluate the potential of these methods and specific positive outcomes.</P>
Phull, Abdul Rehman,Kim, Song Ja VYDAVATELSTVO SLOVAK ACADEMIC PRESS - BRATISLAVA 2017 Biologia Vol.72 No.11
<P><B>Abstract</B></P><P>Fucoidan is a sulfated polysaccharide widely distributed in brown seaweed. It exhibits several bioactivities, such as anti-cancer, anti-tumor, anti-microbial, anti-diabetic and anti-oxidant properties. However, the effects of fucoidan in chondrocytes are not well established. Previously, we have reported<I>in vitro</I>and<I>in vivo</I>anti-inflammatory effects of fucoidan. In this study, we evaluated the effects and regulatory mechanism of fucoidan derived from<I>Undaria pinnatifida</I>on the cyclooxygenase-2 (COX-2) and type II collagen in rabbit articular chondrocytes. Using western blotting and alcian blue staining, respectively, fucoidan was shown to induce type II collagen and sulfated proteoglycan in a dose- and time-dependent manner. Moreover, fucoidan inhibited the COX-2 expression in a dose- and time-dependent manner and increased the phosphorylation of extracellular signal-regulated kinase (ERK), p38, and AKT kinases in chondrocytes. The inhibition of p38 and AKT using SB203580 and LY294002, respectively, in the presence of fucoidan decreased the expression of type II collagen. However, ERK inhibition using PD98050 stimulated type II collagen expression. Fucoidan increased COX-2 expression in the presence of inhibitors of ERK, p38, and AKT kinases. These results conclusively suggested that fucoidan regulated type II collagen expression via the p38 and AKT pathways, and COX-2 expression via the p38, ERK and AKT pathways in rabbit articular chondrocytes. Moreover, given its ability to mediate cell differentiation and exert anti-inflammatory activity, fucoidan may represent a potential therapeutic substance for use in inflammatory conditions, including arthritis.</P>
Phull, A.R.,Kim, S.J. ELSEVIER SCIENCE B.V.; AMSTERDAM 2017 JOURNAL OF FUNCTIONAL FOODS Vol.38 No.1
Fucoidan is a bio-functional polysaccharide, mainly reported in brown seaweed. Diverse potential of fucoidan has created intense interest to review the existing scientific literature, specifically focusing on prevention, associated molecular mechanisms in inflammation related ailments. Fucoidan inhibited inflammatory responses, both in vitro and in vivo experimental models. Inflammation is a complex response of living systems and involved in pathogenesis of different diseases, including arthritis, cancer and allergies. Sulfated glycans play a crucial role in inflammation related events such as they partake in the regulation of chemokines, rolling of leukocytes along the endothelium at inflammatory sites, and provide the structural assembly of subendothelial basement membrane. These functions make fucoidan as suitable exogenous sulfated polysaccharide to ameliorate the inflammatory events like regulating pro-inflammatory targets. Henceforth present study was carried out to provide the critical approach towards the anti-inflammatory properties and underlying molecular mechanisms on the basis of existing knowledge.
Oxidative stress, consequences and ROS mediated cellular signaling in rheumatoid arthritis
Phull, Abdul-Rehman,Nasir, Bakht,Haq, Ihsan ul,Kim, Song Ja Elsevier Pub. Co 2018 Chemico-biological interactions Vol.281 No.-
<P><B>Abstract</B></P> <P>There are numerous extra- and intra-cellular processes involved in the production of reactive oxygen species (ROS). Augmented ROS generation can cause the damage of biomolecules such as proteins, nucleic acid and lipids. ROS act as an intracellular signaling component and is associated with various inflammatory responses, chronic arthropathies, including rheumatoid arthritis (RA). It is well documented that ROS can activate different signaling pathways having a vital importance in the patho-physiology of RA. Hence, understanding of the molecular pathways and their interaction might be advantageous in the development of novel therapeutic approaches for RA.</P>
Balasaheb D. Vanjare,Prasad G. Mahajan,Nilam C. Dige,PHULL ABDUL REHMAN,김송자,이기환 대한화학회 2019 Bulletin of the Korean Chemical Society Vol.40 No.6
Rhodamine derivatives have been persistently used as fluorescent/solvatochromic dyes in various areas. For example, they are used as a labeling agent in biotechnology and a chemosensor. Also, rhodamine derivatives are used for cell imaging experiment. Herein, we report on the synthesis of fluorescent derivatives based on rhodamine B (RHB1, RHB2, and RHB3). We confirmed the structures and purities of the synthesized probes i.e., RHB1, RHB2, and RHB3 by using analytical technique's viz. 1H NMR, 13C NMR, Mass and FT-IR followed by exploring spectroscopic properties by using fluorescence/UV absorption spectroscopy. The effect of solvents on the fluorescence and absorption properties of the synthesized compounds has been comprehensively studied using a series of solvent. In addition, synthesized RHB1, RHB2, and RHB3 were found to be non-toxic against the cancer cell (MDA-MB-231). It is clear from the result of the conventional fluorescence microscopy that probe RHB2 exhibits significant optical properties as compared with those of RHB1 and RHB3.
Mahajan, Prasad G.,Dige, Nilam C.,Vanjare, Balasaheb D.,Phull, Abdul Rehman,Kim, Song Ja,Lee, Ki Hwan Elsevier 2019 Journal of luminescence Vol.206 No.-
<P><B>Abstract</B></P> <P>A simple approach has been developed to prepare gallotannin (GT) mediated silver nanoparticles (AgNPs) for detection of Hg<SUP>2+</SUP> ion in aqueous solution. The synthesized silver nanoparticles was characterized by different techniques such as UV–vis spectrophotometry, XRD, scanning electron microscopy, and EDX. Amongst the all metal ion tested, only Hg<SUP>2+</SUP> shows selective colorimetric and fluorimetric change to GT capped AgNPs. A quick naked eye color change of GT capped AgNPs from yellowish-brown to colorless shows high sensitivity of present method. With addition of Hg<SUP>2+</SUP> ion, the fluorescence enhancement was observed for GT capped AgNPs. The mechanism for the change in color and fluorescence enhancement of nanoparticles with addition of incremental amount of Hg<SUP>2+</SUP> is due to the change in polarization near metal surface region and internal charge transfer phenomenon. The linear range for the detection of Hg<SUP>2+</SUP> was found to be 0.1–1 nM with lower detection limit (LOD) 0.037 nM. The present approach has been successfully utilized to quantitative determination of Hg<SUP>2+</SUP> from environmental samples. The another advantages of prepared silver nanoparticles (GT-AgNPs) is that it shows significant photocatalytic activity for organic transformation and anticancer potential against cancer cell line MDA-MB-231 and A375 with an LD<SUB>50</SUB> of 111.5 µg/mL and 185 µg/mL, respectively.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>