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강상훈,Phan Thai Trung,이호경,조성원,이기성 한국지능시스템학회 2020 한국지능시스템학회논문지 Vol.30 No.1
본 논문에서는 스마트 홈 연구의 일환으로 가정 내의 위험 음향 감지를 위한 새로운 시스템을 제안한다. 제안하는 위험음향 감지 시스템에서는 음향 신호의 특징추출을 위해 변형 MFCC(Mel- Frequency Cepstral Coefficient)을 이용한다. 변형MFCC는 기존 MFCC에서 DCT(Discrete Cosine Transform)를 제거하고 Wiener필터를 추가한 변형된 필터뱅크를 사용한다. Wiener필터는 잡음(Noise) 제거 기능을 하고, 필터뱅크의 변형은 배경음 제거 및 위험 음향데이터의 인식률 향상을 위해적용된다. 기존 MFCC와의 성능을 비교하기 위해 딥러닝 분류기로 시계열 데이터에 적합한 LSTM(Long short-Term Memory)을이용하여 학습 정확도와 인식률 실험을 하였다. 실험 결과, 변형 MFCC가 기존 MFCC에 비해 학습 정확도 개선 및 인식률향상이 가능함을 확인하였다.
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HER2 Status and Its Heterogeneity in Gastric Carcinoma of Vietnamese Patient
Dang Anh Thu Phan,Vu Thien Nguyen,Thi Ngoc Ha Hua,Quoc Dat Ngo,Thi Phuong Thao Doan,Sao Trung Nguyen,Anh Tu Thai,Van Thanh Nguyen 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.4
Background: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy with trastuzumab. Methods: We investigated 208 gastric cancer specimens using immunohistochemistry (IHC), fluorescence in situ hybridization and dual in situ hybridization (ISH). We also investigated the concordance between IHC and ISH. The correlation between HER2 status and various clinicopathological findings was also investigated. Results: In total, 15.9% (33/208) and 24.5% (51/208) of gastric cancers showed HER2 gene amplification and protein overexpression, respectively. A high level of concordance between ISH and IHC analyses (91.3%, κ = 0.76) was found. A significant correlation between HER2 status and intestinal-type (p < .05) and differentiated carcinomas (p < .05) was also noted. The HER2 heterogeneity was high in gastric cancers; we found 68.8% phenotypic heterogeneity and 57.6% genotypic heterogeneity. Heterogeneity in HER2 protein expression and gene amplification showed a close association with diffuse histologic type and IHC 2+. Conclusions: HER2 protein overexpression and gene amplification were detected in 24.5% and 15.9% of gastric cancer specimens, respectively. Intestinal-type showed a higher level of HER2 protein overexpression and gene amplification than diffuse type. HER2 status also showed a significant relationship with well- and moderately-differentiated carcinomas. The ratio of phenotypic and genotypic heterogeneity of HER2 was high in gastric carcinomas and was associated with HER2 IHC 2+ and diffuse histologic type.
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