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Raehyun KIM,Peter ATTAYEK,Yuli WANG,Kathleen FURTADO,Rita TAMAYO,Christopher SIMS,Nancy ALLBRITTON 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Healthy human bodies host hundreds of trillion microbes. More than 99% of these microbes colonize the gut. These gut microbes, also called gut microbiota, have huge impacts on the health and disease states of the hosts. An in vitro intestinal model system that enables co-culturing the gut microbes with human cells can be a valuable tool to elucidate their interaction. However, creating a model system that possesses a proper oxygen gradient to meet different oxygen demands of the gut microbes, primarily obligate anaerobic bacteria, and the human cells, has been challenging. Here, we show a simple in vitro human colon model system that creates the physiological oxygen gradient by utilizing the cellular oxygen consumption and modulating oxygen influx. The behaviors of the primary human colon epithelial cells in the oxygen gradient were compared to those cultured in the conventional aerobic condition. Multiple obligate anaerobic gut bacterial strains were successfully co-cultured in the model system. This novel and simple in vitro colon model system may be a valuable tool to study the interaction of gut bacteria and the host cells.