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- 저자 : Peng Chaohua (검색결과 2 건)
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Wanhong Peng,Qingyu Tan,Minglan Yu,Ping Wang,Tingting Wang,Jixiang Yuan,Dongmei Liu,Dechao Chen,Chaohua Huang,Youguo Tan,Kezhi Liu,Bo Xiang,Xuemei Liang 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.5
Objective Schizophrenia (SCZ) is one of the most common and severe mental disorders. Modified electroconvulsive therapy (MECT) is the most effective therapy for all kinds of SCZ, and the underlying molecular mechanism remains unclear. This study is aim to detect the molecule mechanism by constructing the transcriptome dataset from SCZ patients treated with MECT and health controls (HCs).Methods Transcriptome sequencing was performed on blood samples of 8 SCZ (BECT: before MECT; AECT: after MECT) and 8 HCs, weighted gene co-expression network analysis (WGCNA) was used to cluster the different expression genes, enrichment and protein-protein interaction (PPI) enrichment analysis were used to detect the related pathways.Results Three gene modules (black, blue and turquoise) were significantly associated with MECT, enrichment analysis found that the long-term potentiation pathway was associated with MECT. PPI enrichment p-value of black, blue, turquoise module are 0.00127, <1×10<sup>-16</sup> and 1.09×10<sup>-13</sup>, respectively. At the same time, EP300 is a key node in the PPI for genes in black module, which got from the transcriptome sequencing data.Conclusion It is suggested that the long-term potentiation pathways were associated with biological mechanism of MECT.
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Nurses' Perceptions of Factors Influencing Elder Self-neglect: A Qualitative Study
Wu Meiliyang,Peng Chaohua,Chen Ye,Yuan Mengmei,Zhao Meizhen,Wang Chengshuang,Zeng Tieying 한국간호과학회 2020 Asian Nursing Research Vol.14 No.3
Purpose: Elder self-neglect is a global public health issue and should be taken seriously at large. Nurses, usually working directly with elderly patients, have a better understanding of what factors may cause elder self-neglect. In this qualitative study, we explored the influencing factors of elder self-neglect from the perception of nurses in the context of Chinese culture. Methods: Face-to-face, in-depth interviews were conducted from November 2018 to December 2018. Purposive sampling was used. Twenty one participants recruited from eight geriatric wards of a general hospital located in Wuhan were interviewed. A content analysis of qualitative nature was performed to analyze the data. Results: Our conceptual model illustrated the findings based on the three themes of the conflict between personal recognition and social judgment, the choice between current needs and individual beliefs, as well as the compromise between insufficient abilities and limited resources. Conclusion: Nurses together with family members and social workers can help older adults improve their awareness of self-neglect to bridge the gap with social judgment, learn to focus on their own needs, as well as seek as much support as possible. Nurses should also respect the autonomy and selfdetermination of elder self-neglecters because self-neglect is related to older adults' values. Furthermore, larger studies are needed to quantitatively test and refine the model.
KCI
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