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RISS 인기검색어
- 검색키워드
- 저자 : Peirong Ren (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Peirong Ren,Zhengxing Zuo,Weiqing Huang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.8
The effects of axial profile parameters on the main bearing performance of the engine were investigated through the numerical method based on elasto-hydrodynamic lubrication theory, average flow, and asperity contact model. Results show that quadratic profile significantly improves the bearing performance, and the influence of profile varies with its width-toheight ratio. The performance is most improved when the ratio is between 0.8 and 2. An artificial neural network fitting model was developed to predict bearing performance, and multiobjective optimum analyses were performed using genetic algorithm and particle swarm optimization. The optimization goals are average peak asperity contact pressure and average total friction loss. The obtained Pareto front roughly includes three groups, and solutions in group 1 achieve a balance of the two goals, with a width-to-height ratio of 1.5-2. Finally, bearing friction tests were conducted on four profiled bearings to verify the simulation model and optimization results.
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Yang, Lishi,Li, Junyang,Fu, Shaozhi,Ren, Peirong,Tang, Juan,Wang, Na,Shi, Xiangxiang,Wu, Jingbo,Lin, Sheng Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.4
The brain is the most common metastatic site of lung adenocarcinoma; however, the mechanism of this selective metastasis remains unclear. We aimed to verify the hypothesis that exposure of tumor cells to the brain microenvironment leads to changes in their gene expression, which promotes their oriented transfer to the brain. A549 and H1299 lung adenocarcinoma cells were exposed to human astrocyte-conditioned medium to simulate the brain microenvironment. Microarray analysis was used to identify differentially expressed genes, which were confirmed by quantitative real-time PCR and western blotting. Knockdown experiments using microRNAs and the overexpression of genes by cell transfection were performed in addition to migration and invasion assays. In vitro findings were confirmed in clinical specimens using immunohistochemistry. We found and confirmed a significant increase in insulin-like growth factor binding protein-3 (IGFBP3) levels. Our results also showed that the up-regulation of IGFBP3 promoted A549 cell epithelial-mesenchymal transition, migration, and invasion, while the knockdown of IGFBP3 resulted in decreased cell motility. We also found that Transforming growth factor-${\beta}$ (TGF-${\beta}$)/Mothers against decapentaplegic homolog 4 (Smad4)-induced epithelial-mesenchymal transition was likely IGFBP3-dependent in A549 cells. Finally, expression of IGFBP3 was significantly elevated in pulmonary cancer tissues and intracranial metastatic tissues. Our data indicate that up-regulation of IGFBP3 might mediate brain metastasis in lung adenocarcinoma, which makes it a potential therapeutic target.
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Lishi Yang,Junyang Li,Shaozhi Fu,Peirong Ren,Juan Tang,Na Wang,Xiangxiang Shi,Jing-bo Wu,Sheng Lin 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.4
The brain is the most common metastatic site of lung adenocarcinoma; however, the mechanism of this selective metastasis remains unclear. We aimed to verify the hypothesis that exposure of tumor cells to the brain microenvironment leads to changes in their gene expression, which promotes their oriented transfer to the brain. A549 and H1299 lung adenocarcinoma cells were exposed to human astrocyte-conditioned medium to simulate the brain microenvironment. Microarray analysis was used to identify differentially expressed genes, which were confirmed by quantitative real-time PCR and western blotting. Knockdown experiments using microRNAs and the overexpression of genes by cell transfection were performed in addition to migration and invasion assays. In vitro findings were confirmed in clinical specimens using immunohistochemistry. We found and confirmed a significant increase in insulin-like growth factor binding protein-3 (IGFBP3) levels. Our results also showed that the up-regulation of IGFBP3 promoted A549 cell epithelial-mesenchymal transition, migration, and invasion, while the knockdown of IGFBP3 resulted in decreased cell motility. We also found that Transforming growth factor-β (TGF-β)/Mothers against decapentaplegic homolog 4 (Smad4)-induced epithelial-mesenchymal transition was likely IGFBP3-dependent in A549 cells. Finally, expression of IGFBP3 was significantly elevated in pulmonary cancer tissues and intracranial metastatic tissues. Our data indicate that up-regulation of IGFBP3 might mediate brain metastasis in lung adenocarcinoma, which makes it a potential therapeutic target.
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