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- 저자 : Paul Mills (검색결과 6 건)
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李性寬,Mills, Paul K.,金重剛,宋達浩 최신의학사 1977 最新醫學 Vol.20 No.2
今般 農村地域部落에서의 結核蔓延調査에서 結核有病率이 높은 部落에서는 部落內 指導層, 卽 많은 部落民과 接觸이 많은 有志人士에서 傳染性結核患者가 傳染源으로 役割했음을 確認하였고 農村의 共通的인 蔓延源으로서 氏族部落形成이 또한 重大한 役割을 함을 確認하였으며 有病率이 높은 部落에서 氏族形成率이 높음을 確認하였다. Mass tuberculosis survey in two rural villages showed a much higher infection and prevalence rate of tuberculosis in one of the villages even though both villages are very similar various reasons for this situation have been noted including the fact that influential community members -who have frequent contact with many villagers are open tuberculosis patients. In the future it is recommended that control activities concentrate on such individuals and that strenuous efforts be -made to convert them to sputum negative at the earliest possible date. X-ray screening in the two villages showed a distinctive familial pattern in both villages ,under study. Certain family units were shown to have much higher active case rates than other family units. Therefore it is our conviction that in the future tuberculosis control programs in Korea direct their control activities towards those family units which display higher prevalence rates
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Australia`s ICT Skill base, Future Skill Needs and the Information Economy
GOUGH-WATSON, JANET BANCROFT,MILLS, PAUL 이화여자대학교 국제통상협력연구소 2002 Jounal of APEC Studies Vol.4 No.1
Australia's use of Information Communication Technology (ICT) is extensive and Australia views its ICT industries as key enabling in-dustries as well as being important in their own right in terms of employment and income generation. Australia has therefore mark-edly increased its supply of ICT skills through university level and vocational education and training courses as well as through migra-tion in recent years. ICT employment is expected to continue to grow rapidly in the period ahead, notwithstanding the effects of the dot.com impolsion.
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Ziegler Michael G.,Milic Milos,Dimsdale Joel E.,Mills Paul J. 대한고혈압학회 2024 Clinical Hypertension Vol.30 No.-
Obstructive sleep apnea (OSA) is associated with high blood pressure that responds poorly to usual antihypertensive therapy. Forty-one subjects with OSA had 25% higher plasma norepinephrine and 42% higher epinephrine measured every 2 h over 24 h than 20 control subjects. They also excreted more sodium during sleep. This suggested that that a sympatholytic would be a more successful antihypertensive than a diuretic. To test this hypothesis we treated a second group of 23 hypertensive apneics with placebo, 6 weeks of the sympatholytic guanfacine and 6 weeks of hydrochlorothiazide in a crossover study. Guanfacine lowered 24-hour blood pressure by 9.6/6.7 mmHg, more than the 5.4/2.9 mmHg effect of hydrochlorothiazide ( P < 0.05). Nighttime systolic blood pressure dipping was poor at 6.6 ± 1.8%. Hydrochlorothiazide did not alter blood pressure dipping but guanfacine improved dipping to 9.1 ± 1.2%, a better result ( P = 0.03) than from the diuretic. Central aortic pressure by pulse wave analysis was 120/84 mmHg on hydrochlorothiazide and 109/72 on guanfacine, ( P < 0.05). Guanfacine, but not hydrochlorothiazide, improved baroreflex sensitivity, heart rate variability and flow mediated vascular dilation, suggesting that decreasing the elevated sympathetic nerve activity of obstructive sleep apnea returned vascular function toward normal. OSA is the most common condition associated with antihypertensive treatment failure. It increased sympathetic nerve activity day and night. Drugs that block sympathetic nerve function are not among the 4 most commonly recommended classes of antihypertensives but diuretics are. Sympatholytic therapy was superior to diuretic treatment for hypertension associated with sleep apnea. NCT, NCT02699125, Registered 26 February 2016 - Retrospectively registered, https://clinicaltrials.gov/study/NCT02699125 . Background Obstructive sleep apnea (OSA) is associated with high blood pressure that responds poorly to usual antihypertensive therapy. Methods and results Forty-one subjects with OSA had 25% higher plasma norepinephrine and 42% higher epinephrine measured every 2 h over 24 h than 20 control subjects. They also excreted more sodium during sleep. This suggested that that a sympatholytic would be a more successful antihypertensive than a diuretic. To test this hypothesis we treated a second group of 23 hypertensive apneics with placebo, 6 weeks of the sympatholytic guanfacine and 6 weeks of hydrochlorothiazide in a crossover study. Guanfacine lowered 24-hour blood pressure by 9.6/6.7 mmHg, more than the 5.4/2.9 mmHg effect of hydrochlorothiazide (P < 0.05). Nighttime systolic blood pressure dipping was poor at 6.6 ± 1.8%. Hydrochlorothiazide did not alter blood pressure dipping but guanfacine improved dipping to 9.1 ± 1.2%, a better result (P = 0.03) than from the diuretic. Central aortic pressure by pulse wave analysis was 120/84 mmHg on hydrochlorothiazide and 109/72 on guanfacine, (P < 0.05). Guanfacine, but not hydrochlorothiazide, improved baroreflex sensitivity, heart rate variability and flow mediated vascular dilation, suggesting that decreasing the elevated sympathetic nerve activity of obstructive sleep apnea returned vascular function toward normal. Conclusions OSA is the most common condition associated with antihypertensive treatment failure. It increased sympathetic nerve activity day and night. Drugs that block sympathetic nerve function are not among the 4 most commonly recommended classes of antihypertensives but diuretics are. Sympatholytic therapy was superior to diuretic treatment for hypertension associated with sleep apnea. Trial registration NCT, NCT02699125, Registered 26 February 2016 - Retrospectively registered, https://clinicaltrials. gov/study/NCT02699125.
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