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RISS 인기검색어
- 검색키워드
- 저자 : P.S. Naidu (검색결과 5 건)
- 무료
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Protective Effect of Quercetin on Alcohol Abstinence-Induced Anxiety and Convulsions
S.K. Kulkarni,D. Joshi,P.S. Naidu,A. Singh 한국식품영양과학회 2005 Journal of medicinal food Vol.8 No.3
Chronic administration of ethanol (2 g/kg, p.o.) on days 16 and its withdrawal produced an anxiogenic reac-tion in mice as assessed in the mirrored-chamber test. Daily administration of quercetin (25 or 50 mg/kg, p.o.) prior to ethanolfor 6 days prevented withdrawal-induced anxiety in mice. However, acute administration of a single dose of quercetin (50mg/kg) to animals withdrawn from ethanol, i.e., on day 7, did not prevent withdrawal-induced anxiety. Ethanol withdrawalalso induced a significant increase in the locomotor activity of mice indicating an anxiogenic response. Daily administrationof quercetin (25 or 50 mg/kg, p.o.) prior to ethanol for 6 days prevented withdrawal-induced increased locomotor activity.Ethanol withdrawal also sensitized the convulsogenic reaction to pentylenetetrazole (PTZ). A non-convulsive dose (4060mg/kg) of PTZ produced full-blown convulsions and increased mortality in ethanol-withdrawn mice. Both acute and chronicadministration of quercetin (25 or 50 mg/kg, p.o.) produced a significant protection against ethanol withdrawal-induced re-duction in PTZ threshold in mice. The result suggests the protective effect of this safe drug, quercetin, in the management ofethanol withdrawal reactions.
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A New Methodology for Software Reliability based on Statistical Modeling
Avinash S,Y.Srinivas,P.Annan naidu International Journal of Computer ScienceNetwork S 2023 International journal of computer science and netw Vol.23 No.9
Reliability is one of the computable quality features of the software. To assess the reliability the software reliability growth models(SRGMS) are used at different test times based on statistical learning models. In all situations, Tradational time-based SRGMS may not be enough, and such models cannot recognize errors in small and medium sized applications.Numerous traditional reliability measures are used to test software errors during application development and testing. In the software testing and maintenance phase, however, new errors are taken into consideration in real time in order to decide the reliability estimate. In this article, we suggest using the Weibull model as a computational approach to eradicate the problem of software reliability modeling. In the suggested model, a new distribution model is suggested to improve the reliability estimation method. We compute the model developed and stabilize its efficiency with other popular software reliability growth models from the research publication. Our assessment results show that the proposed Model is worthier to S-shaped Yamada, Generalized Poisson, NHPP.
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Anil Kumar,P.S. Naidu,N. Seghal,S.S.V. Padi 한국식품영양과학회 2007 Journal of medicinal food Vol.10 No.3
This study was designed to investigate the protective effects of curcumin against colchicine-induced cognitiveimpairment and oxidative stress in rats. Male Wistar rats (weighing 150200 g) received colchicine intracerebroventricularly(15 .g per rat), and cognitive dysfunctions were evaluated by the Morris water maze and the plus maze performance task andsupported by biochemical tests. Central administration of colchicine caused memory deficit in both the Morris water mazeand the elevated plus maze task paradigm tasks. Chronic treatment with curcumin (550 mg/kg, p.o.) twice daily for a periodof 25 days beginning 4 days prior to colchicine injection significantly improved the colchicine-induced cognitive impairment.Biochemically, chronic administration of curcumin significantly reduced the elevated lipid peroxidation, restored the decreasedreduced glutathione level and acetylcholinesterase activity, and attenuated the raised colchicine-induced elevated nitrite lev-els. The results of the present study indicate that curcumin has a protective role against colchicine-induced cognitive impair-ment and associated oxidative stress.
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S. Sonia,R. Jayasudha,Naidu Dhanpal Jayram,P. Suresh Kumar,D. Mangalaraj,S.R. Prabagaran 한국물리학회 2016 Current Applied Physics Vol.16 No.8
Hierarchical cupric oxide (CuO) nanostructures (such as nanoflowers, nanorods, nanoleaves and nanoflakes) were synthesized by low temperature sonochemical method and studied its biocompatible and antibacterial functionality. The antibacterial activity of CuO nanostructures in three different concentrations (12.5 mg/ml, 25 mg/ml and 50 mg/ml) have been studied through agar diffusion method against four pathogenic bacteria viz., Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhimurium, and Serratia marcescens. Nanoflowers exhibited more antibacterial activity than nanorods, nanoleaves and nanoflakes, which may be of high specific surface area of nanoflowers (58.63 m2/g). The minimum inhibitory concentration (MIC) for all the compounds is 12.5 mg/ml and showed the maximum zone of inhibition (43 ± 0.5 mm) at 50 mg/ml concentration. Hence our study strongly proved that the synthesized CuO nanostructures can act as excellent antibacterial agents towards human pathogens.
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