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- 저자 : Owen Woods (검색결과 2 건)
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Locacorten Vioform Ototoxicity Upon Guinea Pig Middle Ear Application
Owen Woods,Issam Saliba 대한청각학회 2018 Journal of Audiology & Otology Vol.22 No.2
Locacorten Vioform (Novartis UK) is frequently prescribed forotomycosis. Its component, Clioquinol, also has anti-bacterial properties. Up to this point, itsototoxic potential has not been evaluated. Our objective aims to evaluate Locacorten Vioform’spotential ototoxicity when applied directly to the middle ear cavity. Materials andMethods: We performed an experimental prospective animal study in our animal researchcenter with 20 Hartley guinea pigs divided into 2 groups. The first group (experimental) wastreated with Locacorten Vioform in one ear and with a physiologic saline solution in the other. The second group (positive control) was treated with concentrated gentamycin in one earand physiologic saline in the other. Auditory brainstem response measurements were obtainedbefore and after three sets of injections. Statistics were analyzed using a varianceanalysis with repeated measures. The histological state of cochlear outer hair cells was comparedbetween the two groups using scanning electron microscopy. Results: Average hearingloss in ears treated with Locacorten Vioform was 32.1 dB, compared with a 2.5 dB averageloss in the saline-treated ears. Ears treated with gentamycin lost an average of 33.0 dB. There were clinically and statistically significant differences between the two ears of the guineapigs in both groups (p<0.001). Scanning electron microscopy revealed severe pericochlearand cochlear inflammation and ossification in the Locacorten Vioform-treated ears. Gentamycin caused significant destruction of outer hair cell architecture. Conclusions: LocacortenVioform induces a hearing loss similar to that caused by gentamycin when applieddirectly to the middle ear of a guinea pig model. Electron microscopy indicates a pericochlearand cochlear inflammatory reaction with ossification.
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Olgierd (Olek) Cecil Zienkiewicz (1921 - 2009): A Biographical Tribute
D. Roger J. Owen,Richard D. Wood 한국소성가공학회 2010 기타자료 Vol.2010 No.6
In this tribute the authors present a personal and academic biography of O. C. Zienkiewicz .(1921 - 2009) who is recognized as having been one of the pioneers of the Finite Element Method. O. C. Zienkiewicz co-authored the first text book on the method which was largely responsible for the introduction of the concept to a worldwide audience. His contribution to the computational mechanics community encompasses structural, geotechnical and fluid flow analysis as well as numerous fundamental finite element developments. This paper presents these achievements within the context of his life and includes personal recollections by the authors who were his colleagues.
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