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Ogedengbe, Oluwatosin O,Jegede, Ayoola I,Onanuga, Ismail O,Offor, Ugochukwu,Naidu, Edwin CS,Peter, Aniekan I,Azu, Onyemaechi O Korean Society of ToxicologyKorea Environmental Mu 2016 Toxicological Research Vol.32 No.4
Increased access to highly active antiretroviral therapy (HAART) has made the management of drug toxicities an increasingly crucial component of HIV. This study investigated the effects of adjuvant use of coconut oil and HAART on testicular morphology and seminal parameters in Sprague-Dawley rats. Twelve adult male Sprague-Dawley rats, weighing 153~169 g were distributed into four groups (A-D) and treated as follows: A served as control (distilled water); B (HAART cocktail-Zidovudine, Lamivudine and Nevirapine); C (HAART + Virgin coconut oil 10 mL/kg) and D (Virgin coconut oil 10 mL/kg). After 56 days of treatment, animals were killed and laparotomy to exercise the epididymis for seminal fluid analyses done whilst testicular tissues were processed for histo-morphometric studies. Result showed a significant decline in sperm motility (P < 0.05) and count (P < 0.0001) in HAART-treated animals while there was insignificant changes in other parameters in groups C and D except count that was reduced (P < 0.0001) when compared with controls. Histomorphological studies showed HAART caused disorders in seminiferous tubular architecture with significant (P < 0.01) decline in epithelial height closely mirrored by extensive reticulin framework and positive PAS cells. Adjuvant Virgin coconut oil + HAART resulted in significant decrease in seminiferous tubular diameter (P < 0.05), but other morphometric and histological parameters were similar to control or Virgin coconut oil alone (which showed normal histoarchitecture levels). While derangements in testicular and seminal fluid parameters occurred following HAART, adjuvant treatment with Virgin coconut oil restored the distortions emanating thereof.
Halimah Odunayo AMUDA,Ayotola Olubunmi ONANUGA 건국대학교 지식콘텐츠연구소 2024 International Journal of Knowledge Content Develop Vol.14 No.1
In order to support the mission of the institution in which they are attached, academic libraries provide services in both manual and digital but COVID -19 pandemic that spanned between March and September, 2020 has changed the scenario. With particular reference to Nigeria, about 249,606 cases were confirmed and in order to curb the scourge of this deadly disease, physical academic activities were prevented by Nigeria Centre for Disease Control (NCDC). With this development, innovative tools became indispensable tools for successful delivery of library services in Nigerian academic libraries. Whether or not these tools are still in use for reformation of library service during post- Covid era remains unclear, hence, need for this study. This study examined librarians’ use of innovative tools for information dissemination in Nigerian academic libraries during the post-Covid era using a descriptive survey design. Data were obtained both in quantitative and qualitative formats from one hundred and forty-four librarians as respondents. A total enumeration sampling technique was adopted because the population was minimal. Findings of the study revealed that innovative tools such as videoconferencing, WhatsApp, teleconferencing, Facebook, LinkedIn, and web-based learning applications are still in use by librarians for the dissemination of information during the post-Covid era. These tools are useful and beneficial to librarians during the post-COVID era, as they facilitate easy participation and engagement of library users in various discussions. Inadequate funding and lack of advanced technology skills were also identified as major impediments to the successful use of innovative tools for information dissemination. As a result, it was suggested that academic libraries throughout Nigeria prioritize staff training on the necessary digital skills needed to cope in this advanced technology era.
Oluwatosin O Ogedengbe,Ayoola I Jegede,Ismail O Onanuga,Ugochukwu Offor,Edwin CS Naidu,Aniekan I Peter,Onyemaechi O Azu 한국독성학회 2016 Toxicological Research Vol.32 No.4
Increased access to highly active antiretroviral therapy (HAART) has made the management of drug toxicities an increasingly crucial component of HIV. This study investigated the effects of adjuvant use of coconut oil and HAART on testicular morphology and seminal parameters in Sprague- Dawley rats. Twelve adult male Sprague-Dawley rats, weighing 153~169 g were distributed into four groups (A-D) and treated as follows: A served as control (distilled water); B (HAART cocktail- Zidovudine, Lamivudine and Nevirapine); C (HAART + Virgin coconut oil 10 mL/kg) and D (Virgin coconut oil 10 mL/kg). After 56 days of treatment, animals were killed and laparotomy to exercise the epididymis for seminal fluid analyses done whilst testicular tissues were processed for histo-morphometric studies. Result showed a significant decline in sperm motility (P < 0.05) and count (P < 0.0001) in HAART-treated animals while there was insignificant changes in other parameters in groups C and D except count that was reduced (P < 0.0001) when compared with controls. Histomorphological studies showed HAART caused disorders in seminiferous tubular architecture with significant (P < 0.01) decline in epithelial height closely mirrored by extensive reticulin framework and positive PAS cells. Adjuvant Virgin coconut oil + HAART resulted in significant decrease in seminiferous tubular diameter (P < 0.05), but other morphometric and histological parameters were similar to control or Virgin coconut oil alone (which showed normal histoarchitecture levels). While derangements in testicular and seminal fluid parameters occurred following HAART, adjuvant treatment with Virgin coconut oil restored the distortions emanating thereof.