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RISS 인기검색어
- 검색키워드
- 저자 : Ohashi Takashi (검색결과 4 건)
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Ohashi Takashi,Fujita Yukiyoshi,Irisawa Hiroyuki,Nakaminami Hidemasa,Arai Takahiro,Takahashi Masumi,Momiyama Emi,Murata Naoya,Murayama Kayoko,Saito Taeko 대한감염학회 2022 Infection and Chemotherapy Vol.54 No.1
Background Arbekacin (ABK) is an aminoglycoside that exhibits anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-Pseudomonas aeruginosa activities. Therefore, for patients with febrile neutropenia (FN) and concurrent pneumonia suspected to be caused by MRSA, ABK may be sufficiently effective even as a single agent. Materials and Methods Patients with hematologic malignancies treated with ABK who met the following criteria were included: 1) fever during neutropenia or functional neutropenia, 2) FN complicated by pneumonia, and 3) possible infection by antimicrobial-resistant Gram-positive cocci. Results This study encompassed 22 episodes involving 19 patients, of which, 15 (68.2%) were successfully treated with ABK. Of the nine episodes showing inadequate response to other anti-MRSA drugs, eight were successfully treated with ABK. Grade 2 or worse adverse events included acute kidney injury (13.6%) and increased transaminase levels (9.1%). Conclusion The present study demonstrated that ABK is effective and safe in patients with FN and concurrent pneumonia caused by antimicrobial-resistant Gram-positive cocci. ABK may also be effective in patients who are unresponsive to other anti-MRSA drugs. Therefore, ABK may be beneficial in the treatment of pneumonia caused by antimicrobial-resistant Gram-positive cocci in patients with FN. Background Arbekacin (ABK) is an aminoglycoside that exhibits anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-Pseudomonas aeruginosa activities. Therefore, for patients with febrile neutropenia (FN) and concurrent pneumonia suspected to be caused by MRSA, ABK may be sufficiently effective even as a single agent. Materials and Methods Patients with hematologic malignancies treated with ABK who met the following criteria were included: 1) fever during neutropenia or functional neutropenia, 2) FN complicated by pneumonia, and 3) possible infection by antimicrobial-resistant Gram-positive cocci. Results This study encompassed 22 episodes involving 19 patients, of which, 15 (68.2%) were successfully treated with ABK. Of the nine episodes showing inadequate response to other anti-MRSA drugs, eight were successfully treated with ABK. Grade 2 or worse adverse events included acute kidney injury (13.6%) and increased transaminase levels (9.1%). Conclusion The present study demonstrated that ABK is effective and safe in patients with FN and concurrent pneumonia caused by antimicrobial-resistant Gram-positive cocci. ABK may also be effective in patients who are unresponsive to other anti-MRSA drugs. Therefore, ABK may be beneficial in the treatment of pneumonia caused by antimicrobial-resistant Gram-positive cocci in patients with FN.
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Nano-scale current voltage characteristics of thin film solar cell with light irradiations
Masato Kawai,Tomohiro Kawakami,Tomoya Inaba,Fumitaka Ohashi,Hironori Natsuhara,Takashi Itoh,Shuichi Nonomura 한국물리학회 2010 Current Applied Physics Vol.10 No.3
Nano-scale current voltage (I–V) characteristics of hydrogenated amorphous silicon (a-Si:H) solar cells were studied with and without light irradiations by using conductive Atomic Force Microscope (conductive-AFM). To obtain proper I–V characteristics, electrical contacts between the n-layer of the a-Si solar cells and the cantilever of the AFM were modified by depositing ZnO films with the thickness of 20 nm on the tip using DC sputterer. The I–V characteristics were changed from Schottky like to ohmic like. Surface defects and grain boundaries of the ZnO thin film possibly formed an ohmic-like current path between n-layer and the tip of the cantilever. We measured photo-current map at the bias of -2 V with a resolution of nano-meter scales. High photo-current paths appeared at nano-crystallites formed in the nc-Si:H film of the solar cell while small current area was observed at the boundaries of the small and large grains. This suggests that the boundaries have high impedance created by hydrogen passivation or act as a leakage current path for the photo-current recombination. These results imply that our proposed measurement technique using conductive-AFM combined with covering of ZnO film on the cantilever is a useful tool for the evaluation of the short path of the photo-current. In addition, these techniques contribute to increase the conversion efficiency of thin film solar cells.
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Bin Guo,Mitsuhisa Ichiyanagi,Takuma Ohashi,Qinyue Zheng,Takashi Suzuki 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.7
Ammonia has received significant attention as a fuel due to its carbon-free molecular structure. However, burning ammonia is challenging because of its low laminar burning velocity. To promote the combustion velocity, the authors propose a constant volume combustion chamber with a sub-chamber. This study investigated the effects of the mixing time and equivalence ratio of the ammonia/oxygen/argon mixture on combustion. The mean velocity of the ejection from the sub-chamber can be calculated by evaluating the combustion pressure, mass fraction burned, and volume fraction burned. It was clarified that with the sub-chamber structure, the ejection from the sub-chamber improved the compression and turbulence of unburned gas in the main chamber and increased the mean flame velocity of ammonia combustion. The appropriate glow plug temperature could improve the ignitability of the fuel mixture, leading to increased combustion efficiency, maximum combustion pressure, and reduced combustion time.
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