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5-(4-Hydroxyphenethenyl)-4,7-dime-thoxycoumarin, a New Constituent of Monotes engleri
Seo, Eun-Kyoung,Chai, Hee-Byung,Chagwedera, Tangai E.,Farnsworth, Norman R.,Cordell, Geoffrey A.,Pezzuto, John M.,Kinghorn, A. Douglas 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
A new coumarin, 5-(4-hydroxyphenethenyl)-4,7-dimethoxycoumarin (1) was isolated from the combined ethyl acetate extracts of the root bark, root wood and stem bark of Monotes engleri, and found to be cytotoxic against two cell lines in a human tumor panel. Its structure was determined on the basis of spectroscopic methods.
Novel Cytotoxic Labdane Diterpenoids from Neouvaria acuminatissima
Lee, Ik Soo,Ma, Xianjian,Chai, Hee Byung,Madulid, Domingo A,Lamont, R . Brian,O'Neill, Melanie J .,Besterman, Jeffrey M .,Farnsworth, Norman R .,Soejarto, D . Doel,Cordell, Geoffrey A .,Pezzute, John 전남대학교 약품개발연구소 1996 약품개발연구지 Vol.4 No.1
Acuminolide (1), a cytotoxic labdane diterpene with a new type of carbon skeleton, was isolated from the stem irk of Neouvaria acuminatissima, together with its congeners 17-O-acetylacuminolide (2), and an inactive derivative, spiroacuminolide (3), Their structures were determined on the basis of spectroscopic and chemical methods, as well as X-ray cystallography. Isolation, structure elucidation and bioassay results are described.
New bioactive aromatic compounds from Vismia guianensis
Seo, Eun-Kyoung,Wani, Mansukh C.,Wall, Monroe E.,Navarro, Hernan,Mukherjee, Rabindranath,Farnsworth, Norman R.,Kinghorn, A. Douglas 梨花女子大學校 藥學硏究所 2000 藥學硏究論文集 Vol.- No.9
Five benzophenones, vismiaguianones A-E, and two benzocoumarins, vismiaguianins A and B were isolated from the CHCl_3 extract of the roots of Vismia guianensis by bioassay-directcd fractionation using the DNA strand-scission assay and KB cell line. Of the isolates obtained, vismiaguianone B exhibited DNA strand-scission activity, whereas vismiaguianones D and E and vismiaguianin A were found to be significantly cytotoxic.
Macharistol, a New Cytotoxic Cinnamylphenol from the Stems of Machaerium aristulatum
Seo, Eun-Kyoung,Kim, Nam-Cheol,Mi, Qiuwen,Chai, Heebyung,Wall, Monroe E.,Wani, Mansukh C.,Navarro, Herna´n A.,Burgess, Jason P.,Graham, James G.,Cabieses, Fernando,Tan, Ghee T.,Farnsworth, Norman R.,P 梨花女子大學校 藥學硏究所 2001 藥學硏究論文集 Vol.- No.10
A new clnnamylphenol, machaistol(1), along with a known pterocarpan, (+)-medicarpin(2), were isolated as cytotoxic constituents from the stems of Machaerium aristulatum. In addition, a known pterocarpan, (+)-maackiain(3), and a known isoflavone, formononetin(4), were identified as inactive constituents. Compound 1 was eveluated in the in vivo hollow fiber assay with KB, Col-2, and hTERT-RPE1 cells and found to be inactive at the highest does(25 mg/kg body weight) tested.