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        Chloroplastic NAD(P)H Dehydrogenase Complex and Cyclic Electron Transport around Photosystem I

        Tsuyoshi Endo,Satoshi Ishida,Noriko Ishikawa,Fumihiko Sato 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.2

        Recent molecular genetics studies have revealed that cyclic electron transport around photosystem I is essential for normal photosynthesis and growth of plants. Chloroplastic NAD(P)H dehydorgenase (NDH) complex, a homologue of the complex I in respiratory electron transport, is involved in one of two cyclic pathways. Recent studies on the function and structure of the NDH complex are reviewed

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        Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation

        Takayuki Nakagawa,Keiko Kudoh,Naoyuki Fukuda,Shohei Kasugai,Noriko Tachikawa,Kiyoshi Koyano,Yasuyuki Matsushita,Masanori Sasaki,Kunio Ishikawa,Youji Miyamoto 대한치주과학회 2019 Journal of Periodontal & Implant Science Vol.49 No.6

        Purpose: The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (CO3Ap) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Methods: Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Results: Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the CO3Ap granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the CO3Ap granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual CO3Ap were 33.8%±15.1% and 15.3%±11.9%, respectively. Conclusions: In this first demonstration, low-crystalline CO3Ap granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. CO3Ap granules are a useful and safe bone substitute for two-stage sinus floor augmentation.

      • SCIESCOPUSKCI등재

        Application of low-crystalline carbonate apatite granules in 2-stage sinus floor augmentation: a prospective clinical trial and histomorphometric evaluation

        Nakagawa, Takayuki,Kudoh, Keiko,Fukuda, Naoyuki,Kasugai, Shohei,Tachikawa, Noriko,Koyano, Kiyoshi,Matsushita, Yasuyuki,Sasaki, Masanori,Ishikawa, Kunio,Miyamoto, Youji Korean Academy of Periodontology 2019 Journal of Periodontal & Implant Science Vol.49 No.6

        Purpose: The purpose of this study was to elucidate the efficacy and safety of carbonate apatite (CO<sub>3</sub>Ap) granules in 2-stage sinus floor augmentation through the radiographic and histomorphometric assessment of bone biopsy specimens. Methods: Two-stage sinus floor augmentation was performed on 13 patients with a total of 17 implants. Radiographic assessment using panoramic radiographs was performed immediately after augmentation and was also performed 2 additional times, at 7±2 months and 18±2 months post-augmentation, respectively. Bone biopsy specimens taken from planned implant placement sites underwent micro-computed tomography, after which histological sections were prepared. Results: Postoperative healing of the sinus floor augmentation was uneventful in all cases. The mean preoperative residual bone height was 3.5±1.3 mm, and this was increased to 13.3±1.7 mm by augmentation with the CO<sub>3</sub>Ap granules. The mean height of the augmented site had decreased to 10.7±1.9 mm by 7±2 months after augmentation; however, implants with lengths in the range of 6.5 to 11.5 mm could still be placed. The mean height of the augmented site had decreased to 9.6±1.4 mm by 18±2 months post-augmentation. No implant failure or complications were observed. Few inflammatory cells or foreign body giant cells were observed in the bone biopsy specimens. Although there were individual differences in the amount of new bone detected, new bone was observed to be in direct contact with the CO<sub>3</sub>Ap granules in all cases, without an intermediate layer of fibrous tissue. The amounts of bone and residual CO<sub>3</sub>Ap were 33.8%±15.1% and 15.3%±11.9%, respectively. Conclusions: In this first demonstration, low-crystalline CO<sub>3</sub>Ap granules showed excellent biocompatibility, and bone biopsy showed them to be replaced with bone in humans. CO<sub>3</sub>Ap granules are a useful and safe bone substitute for two-stage sinus floor augmentation.

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