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Development of a simple discarding robot for the media changing process
Ryosuke Nonoyama,Koichiro Yori,Keiichi Sugiura,Makoto Jinno 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
Currently, in regenerative medicine, cell processing is performed manually, which is labor intensive and expensive. Recently, automatic cell culture apparatuses equipped with a vertical articulated robot have been proposed to improve the efficiency of cell-processing tasks. However, most of them automate all the cell-processing tasks, which complicate the system. This study aimed to develop a simple and rational cell-processing system by combining the tasks performed by a robot and human. In a previous study, we proposed a method to improve the efficiency of the media changing process and implemented prototypes that improve the efficiency of discarding and injecting tasks. Herein, we developed and evaluated a simpler discarding robot than the previous model. The proposed discarding robot fulfilled its basic functions. Using the robot, the operator does not need to worry about the liquid-dripping effect during the discarding task. Moreover, the device is equipped with human error countermeasures. Further, as this device is sufficiently small to be used in a safety cabinet, it can be integrated into current culture methods.
Honda, Fumiko,Kano, Hirotsugu,Kanegane, Hirokazu,Nonoyama, Shigeaki,Kim, Eun-Sung,Lee, Sang-Kyou,Takagi, Masatoshi,Mizutani, Shuki,Morio, Tomohiro Nature Publishing Group, a division of Macmillan P 2012 NATURE IMMUNOLOGY Vol.13 No.4
The function of the kinase Btk in neutrophil activation is largely unexplored. Here we found that Btk-deficient neutrophils had more production of reactive oxygen species (ROS) after engagement of Toll-like receptors (TLRs) or receptors for tumor-necrosis factor (TNF), which was associated with more apoptosis and was reversed by transduction of recombinant Btk. Btk-deficient neutrophils in the resting state showed hyperphosphorylation and activation of phosphatidylinositol-3-OH kinase (PI(3)K) and protein tyrosine kinases (PTKs) and were in a 'primed' state with plasma membrane??associated GTPase Rac2. In the absence of Btk, the adaptor Mal was associated with PI(3)K and PTKs at the plasma membrane, whereas in control resting neutrophils, Btk interacted with and confined Mal in the cytoplasm. Our data identify Btk as a critical gatekeeper of neutrophil responses.
Structural Design and Performance Evaluation of a Mid-story Seismic Isolated High-Rise Building
Tamari, Masatoshi,Yoshihara, Tadashi,Miyashita, Masato,Ariyama, Nobuyuki,Nonoyama, Masataka Council on Tall Building and Urban Habitat Korea 2017 International journal of high-rise buildings Vol.6 No.3
This paper describes some of the challenges for structural design of a mid-story seismic isolated high-rise building, which is located near Tokyo station, completed in 2015. The building is a mixed-use complex and encompasses three volumes: one substructure including basement and lower floors, and a pair of seismic isolated superstructures on the substructure. One is a 136.5m high Main Tower (office use), and the other is a 98.5 m high South Tower (hotel use). The seismic isolation systems are arranged in the $3^{rd}$ floor of the Main Tower and $5^{th}$ floor of the South Tower, so that we call this isolation system as the mid-story seismic isolation. The primary goal of the structural design of this building was to secure high seismic safety against the largest earthquake expected in Tokyo. We adopted optimal seismic isolation equipment simulated by dynamic analysis to minimize building damage. On the other hand, wind-induced vibration of a seismic isolated high-rise building tends to be excited. To reduce the vibration, the following strategies were adopted respectively. In the Main Tower with a large wind receiving area, we adopted a mechanism that locks oil dampers at the isolation level during strong wind. In the South Tower, two tuned mass dampers (TMDs) are installed at the top of the building to control the vibration. In addition, our paper will also report the building performance evaluated for wind and seismic observation after completion of the building. In 2016, an earthquake of seismic intensity 3 (JMA scale) occurred twice in Tokyo. The acceleration reduction rate of the seismic isolation level due to these earthquakes was approximately 30 to 60%. These are also verified by dynamic analysis using observed acceleration data. Also, in April 2016, a strong wind exceeding the speed of 25m/s occurred in Tokyo. On the basis of the record at the strong wind, we confirmed that the locking mechanism of oil damper worked as designed.