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Rogozin, E. A.,Lee, K. W.,Kang, N. J.,Yu, H.,Nomura, M.,Miyamoto, K.-I.,Conney, A. H.,Bode, A. M.,Dong, Z. Oxford University Press 2008 Carcinogenesis Vol.29 No.6
<P>Some xanthine analogues, including 1,3,7-trimethylxanthine (caffeine) and 1,3-dimethylxanthine (theophylline), have been shown to exert anticancer activities in both cell culture and animal models. The present study focused on the relationship of structure and activity of 50 different caffeine analogues in preventing epidermal growth factor (EGF)-induced malignant transformation of mouse epidermal JB6 promotion-sensitive (P+) Cl41 (JB6 P+) cells. Results indicated that the inhibition of cell transformation by the 1,3,7-trialkylxanthines depends on the number of carbons at the alkyl groups R1 and R3, but not R7. Notably, 1-ethyl-3-hexylxanthine (xanthine 70) was the most effective compound for inhibiting EGF-induced neoplastic transformation among the 50 xanthine analogues tested. The 50% inhibition of cell transformation (ICT(50)) value for xanthine 70 was 48- or 75-fold less than the ICT(50) value of caffeine or theophylline, respectively. Further study revealed that xanthine 70 (5-40 muM) dose dependently inhibited EGF-induced transactivation of activator protein 1 (AP-1), whereas theophylline or caffeine (up to 500 muM) had no effect on AP-1 activity. In addition, xanthine 70 (10 muM) inhibited 12-O-tetradecanoylphorbol-13-acetate- or H-Ras-induced neoplastic transformation in JB6 P+ cells by 78.2 or 62.0%, respectively. Collectively, these results indicated that the number of carbons at R1 and R3 is important for the antitumor-promoting activity of the trialkylxanthines and xanthine 70 might be a promising anticancer agent.</P>
ALUMINA POWDER PREPARED BY THE HYDROLYSIS OF AL-PROPOXIDE IN THE SUPERCRITICAL FLUID OF PROPANOL
Nakagawa, Nakagawa, Z.,Enomoto, Enomoto, N.,Nomura, Nomura, S.,Kim, Kim, D.W.,Lim, Lim, D.Y. 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.2 No.4
Al-isopropoxide dispersed into isopropanol was heated in an autoclave above the critical point of propanol(23$5^{\circ}C$, 4.7MPa). Propanol coexisting Al-isopropoxide produced some water during the condensation reaction to isopropul ether, while only propanol did not change under that conditions. This water hydrolyzed Al-isopropoxide to form an alumina at 30$5^{\circ}C$ and 11.0MPa. This alumina had a similar X-ray diffraction pattern of $\chi$-alumina. The heating treatment showed the aluminal transformed directly to ${\alpha}$-alumina around 110$0^{\circ}C$, not to pass via any other intermediate aluminas. The aluminal was named pseudo $\chi$-alumina as a new phase. As-prepared alumina was fine powder of about 20nm, and had about 5% weight loss in the temperature range from 30$0^{\circ}C$ to 65$0^{\circ}C$, and the IR spectral showed no constitutional water.