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Sun Yan,Qu Hai,Niu Xiaohong,Li Ting,Wang Lijuan,Peng Hairui 대한약리학회 2024 The Korean Journal of Physiology & Pharmacology Vol.28 No.1
Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and dyslipidemia. Carvacrol (CAR) has demonstrated the potential to mitigate dyslipidemia. This study aims to investigate whether CAR can modulate blood glucose and lipid levels in a T2DM rat model by regulating short-chain fatty acids (SCFAs) and the GPR41/43 pathway. The T2DM rat model was induced by a high-fat diet combined with low-dose streptozocin injection and treated with oral CAR and/or mixed antibiotics. Fasting blood glucose, oral glucose tolerance, and insulin tolerance tests were assessed. Serum lipid parameters, hepatic and renal function indicators, tissue morphology, and SCFAs were measured. In vitro, high glucose (HG)-induced IEC-6 cells were treated with CAR, and optimal CAR concentration was determined. HG-induced IEC-6 cells were treated with SCFAs or/and GPR41/43 agonists. CAR significantly reduced blood lipid and glucose levels, improved tissue damage, and increased SCFA levels in feces and GPR41/43 expression in colonic tissues of T2DM rats. CAR also at tenuated HG-induced apoptosis of IEC-6 cells and enhanced GPR41/43 expression. Overall, these findings suggest that CAR alleviates blood lipid and glucose abnormalities in T2DM rats by modulating SCFAs and the GPR41/43 pathway.
Coherent Quantum Control of Atomic and Molecular Processes by Using the Technique of Laser Pulses
hangqing Gong,Ruxin Li,hiqi Jin,Xiaohong ong,Yueping Niu,Zhizhan Xu 한국물리학회 2005 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.46 No.2
Several schemes for coherent quantum control of atomic and molecular processes have been proposed and investigated by using the techniques of adiabatic passage and ultrashort pulses, respectively. Some interesting results have been found.
Qingna Xu,Tongchao Ji,Qingfeng Tian,Yuhang Su,Liyong Niu,Xiaohong Li,Zhijun Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2018 NANO Vol.13 No.12
A series of silica surface-capped with hexamethyldisilazane (denoted as H-SiO2) were prepared by liquid-phase in-situ surface-modification method. The as-obtained H-SiO2 was incorporated into acrylic amino (AA) baking paint to obtain AA/H-SiO2 composite extinction paints and/or coatings. N2 adsorption–desorption tests were conducted to determine the specific surface area as well as pore size and pore volume of H-SiO2. Moreover, the effects of H-SiO2 matting agents on the physical properties of AA paint as well as the gloss and transmittance of AA-based composite extinction coatings were investigated. Results show that H-SiO2 matting agents possess a large specific surface area and pore volume than previously reported silica obtained by liquid-phase method. Besides, they have better dispersibility in AA baking paint than the unmodified silica. Particularly, H-SiO2 with a silica particle size of 6.7 μm and the dosage of 4% (mass fraction) provides an extinction rate of 95.2% and a transmittance of 79.3% for the AA-based composite extinction coating, showing advantages over OK520, a conventional silica matting agent. Along with the increase in the silica particle size, H-SiO2 matting agents cause a certain degree of increase in the viscosity of AA paint as well as a noticeable decrease in the gloss of the AA-based composite extinction coating, but they have insignificant effects on the hardness and adhesion to substrate of the AA-based composite coatings. This means that H-SiO2 matting agents could be well applicable to preparing low-viscosity and low-gloss AA-based matte coatings.