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- 저자 : Nicolas Noël(Nicolas Noël ) (검색결과 4 건)
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Matthieu Gasnier(Matthieu Gasnier ),Walid Choucha(Walid Choucha ),David Montani(David Montani ),Nicolas Noël(Nicolas Noël ),Céline Verstuyft(Céline Verstuyft ),Francois Radiguer(Francois Radiguer ),Xa 대한정신약물학회 2022 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.20 No.4
Objective: Psychiatric symptoms and mental disorders are common after Coronavirus Disease-19 (COVID-19). Some drugs used to treat acute COVID-19 have psychiatric side effects. We assessed the psychiatric symptoms and mental disorders of patients treated for acute COVID-19 with hydroxychloroquine (HCQ), interleukin-6 receptor antagonists (anti-IL-6), and corticoids (CTC). Methods: We evaluated 177 patients in a day hospital 4 months after acute infection. Results: In a multivariate analysis, HCQ was associated with significant anxiety symptoms (odds ratio [OR] = 5.9, 95% confidence interval [95% CI] = 1.8−20.0, p = 0.003) and mental disorders (OR = 4.1, 95% CI = 1.2−13.9, p = 0.02). In a bivariate analysis with propensity matched cohorts, HCQ was associated with significant anxiety symptoms (9 patients [50.0%] with significant symptoms in the HCQ group versus 15 [20.1%] in the control group, OR = 3.8, 95% CI = 1.3−11.3, p = 0.01). Anti-IL-6 and CTC were not associated with significant psychiatric symptoms or mental disorders. Conclusion: We recommend monitoring psychiatric symptoms, especially anxiety, in patients treated with HCQ during COVID-19 infection. Further studies with larger samples and prospective assessments are needed to confirm our results.
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Loss-of-function mutations in SLC30A8 protect against type 2 diabetes
Flannick, Jason,Thorleifsson, Gudmar,Beer, Nicola L,Jacobs, Suzanne B R,Grarup, Niels,Burtt, Noë,l P,Mahajan, Anubha,Fuchsberger, Christian,Atzmon, Gil,Benediktsson, Rafn,Blangero, John,Bowden, Do Nature Pub. Co 2014 Nature genetics Vol.46 No.4
Loss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2 diabetes (T2D). Through sequencing or genotyping of ∼150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. Collectively, carriers of protein-truncating variants had 65% reduced T2D risk (P = 1.7 × 10<SUP>−6</SUP>), and non-diabetic Icelandic carriers of a frameshift variant (p.Lys34Serfs*50) demonstrated reduced glucose levels (−0.17 s.d., P = 4.6 × 10<SUP>−4</SUP>). The two most common protein-truncating variants (p.Arg138* and p.Lys34Serfs*50) individually associate with T2D protection and encode unstable ZnT8 proteins. Previous functional study of SLC30A8 suggested that reduced zinc transport increases T2D risk, and phenotypic heterogeneity was observed in mouse Slc30a8 knockouts. In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention.
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Engohan-Aloghe, Corinne,Aubain Sommerhausen, Nicolas de Saint,Noë,l, Jean-Christophe Ovid Technologies (Wolters Kluwer) - Lippincott Wi 2009 International journal of gynecological pathology Vol.28 No.6
<P>Desmoplastic small round cell tumor (DSRCT) is a rare aggressive tumor primarily involving serosal surfaces in adolescents and young men. Diagnosis is based on specific clinicomorphologic, immunohistochemical, and genetic features. We report here a variant of DSRCT involving the ovaries that mimics the Sertoli-Leydig cell tumor in a 21-year-old woman complaining of abdominal pain. Abdominal ultrasonography and computed tomography showed a right adnexal mass. She had a slightly raised serum CA-125 level. Frozen section examination identified the right ovarian mass as a poorly differentiated Sertoli-Leydig cell tumor. The surgically resected tumor and left ovary and omentum implants found during laparoscopy were diagnosed as DSRCT with Leydig cell hyperplasia. Immunohistochemically, the tumor cells were negative for epithelial markers but were positive for calretinin and inhibin. The patient is still undergoing chemotherapy at 8 months after initial presentation with partial response. This case showed that DSRCT with unusual immunohistochemical profiles and Leydig cells hyperplasia pose a diagnostic challenge. Molecular genetic techniques may help in these cases.</P>
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Ibraikulov, Olzhas A.,Bechara, Rony,Chavez, Patricia,Bulut, Ibrahim,Tastanbekov, Dias,Leclerc, Nicolas,Hebraud, Anne,Heinrich, Benoî,t,Berson, Solenn,Lemaitre, Noë,lla,Chochos, Christos L.,L& Elsevier 2015 ORGANIC ELECTRONICS Vol.23 No.-
<P><B>Abstract</B></P> <P>In this report, we explore the optoelectronic properties of a low band-gap copolymer based on the alternation of electron rich (thiophene and thienothiophene units) and electron deficient units (pyridal[2,1,3]thiadiazole (Py)). Initial density functional theory calculations point out the interest of using the Py unit to optimize the polymer frontier orbital energy levels. A high molecular weight (<I>M</I> <SUB>n</SUB> =49kg/mol) solution-processable copolymer, based on Py, thiophene and thienothiophene units, has been synthesized successfully. From cyclic-voltammetry and UV–visible absorption measurements a relatively deep HOMO level (−5.1eV) and an optical band-gap (1.48eV) have been estimated. Charge transport both in horizontal and vertical directions were extracted from field-effect transistors and space charge limited current diodes, respectively, and led to a relatively high in-plane hole mobility in pure polymer films (0.7×10<SUP>−2</SUP> cm<SUP>2</SUP> V<SUP>−1</SUP> s<SUP>−1</SUP>). GIWAXS results showed almost identical in-plane lamellar morphologies, with similar average size and orientation of the polymer crystalline domains in both, pure polymer films and polymer:fullerene blends. Also, the gate-voltage dependence of the field-effect mobility revealed that the energy disorder in the polymer domains was not altered by the introduction of fullerenes. The nevertheless significantly higher out-of-plane hole mobility in blends, in comparison to pure polymer films, was attributed to the minor amorphous polymer phase, presumably localized close to the donor/acceptor interface, whose signature was observed by UV–vis absorption. Promising photovoltaic performances could be achieved in a standard device configuration. The corresponding power conversion efficiency of 4.5% is above the value achieved previously with a comparable polymer using benzo [2,1,3]thiadiazole instead of Py as acceptor unit.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A low-band gap copolymer with pyridal[2,1,3]thiadiazole has been synthesized. </LI> <LI> Charge transport was investigated in both, in-plane and out-of plane directions. </LI> <LI> GIWAXS and mobility data reveal lamellar morphology and transport anisotropy. </LI> <LI> Amorphous polymer fraction supports out-of-plane hole mobility in blends. </LI> <LI> A maximum PCE of 4.5% could be achieved. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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