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Van Manh Ngo,Khuong V. Dinh,Bich Lien Chau,Diep Minh Luc 한국수산과학회 2023 Fisheries and Aquatic Sciences Vol.26 No.8
The objective of this study was to evaluate how the tank colours may change the effects of extreme temperature on the survival, growth, and quality of juvenile golden trevally (Gnathanodon speciosus). The experiment was set up with fifteen treatments of five tank colours (blue, red, yellow, grey, and white) and three temperatures (30℃, 32℃, 34℃) with three replications. Fish performance was assessed for four weeks. The results showed that tank colours and elevated temperatures affected the quality of golden trevally juveniles. The survival and growth rate of fish tend to decrease gradually, but the deformation rate of fish tended to increase in the order of tank colours: red, yellow > grey, blue, and white. The growth and survival rate of fish gradually decreased when the rearing temperature increased from 30℃ to 34℃ and this effect was independent of tank colors. Importantly, the deformation rate increased under elevated temperature, particularly in blue and white tanks with potential long-term effects. It is, therefore, not recommended to use blue and white tanks for rearing the golden trevally juveniles, particularly during extremely high temperatures from heatwave events.
Ngo, Van T.H.,Hoang, Van-Hai,Tran, Phuong-Thao,Van Manh, Nguyen,Ann, Jihyae,Kim, Eunhye,Cui, Minghua,Choi, Sun,Lee, Jiyoun,Kim, Hee,Ha, Hee-Jin,Choi, Kwanghyun,Kim, Young-Ho,Lee, Jeewoo Elsevier 2018 Bioorganic & medicinal chemistry Vol.26 No.12
<P><B>Abstract</B></P> <P>Glutamyl cyclase (QC) is a promising therapeutic target because of its involvement in the pathogenesis of Alzheimer’s disease. In this study, we developed novel QC inhibitors that contain 3-aminoalkyloxy-4-methoxyphenyl and 4-aminoalkyloxyphenyl groups to replace the previously developed pharmacophore. Several potent inhibitors were identified, showing IC<SUB>50</SUB> values in a low nanomolar range, and were further studied for <I>in vitro</I> toxicity and <I>in vivo</I> activity. Among these, inhibitors <B>51</B> and <B>53</B> displayed the most potent Aβ<SUB>N3pE−40</SUB>-lowering effects in <I>in vivo</I> acute model with reasonable BBB penetration, without showing cytotoxicity and <I>h</I>ERG inhibition. The molecular modeling analysis of <B>53</B> indicated that the salt bridge interaction and the hydrogen bonding in the active site provided a high potency. Given the potent activity and favorable BBB penetration with low cytotoxicity, we believe that compound <B>53</B> may serve as a potential candidate for anti-Alzheimer’s agents.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hoang, Van-Hai,Ngo, Van T. H.,Cui, Minghua,Manh, Nguyen Van,Tran, Phuong-Thao,Ann, Jihyae,Ha, Hee-Jin,Kim, Hee,Choi, Kwanghyun,Kim, Young-Ho,Chang, Hyerim,Macalino, Stephani Joy Y.,Lee, Jiyoun,Choi, S American Chemical Society 2019 Journal of medicinal chemistry Vol.62 No.17
<P>Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor <B>1</B>, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogues, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational analysis of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.</P> [FIG OMISSION]</BR>
Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Vernonia gratiosa Hance
Cong Pham Van,Anh Hoang Le Tuan,Vinh Le Ba,Han Yoo Kyong,Trung Nguyen Quang,Minh Bui Quang,Duc Ngo Viet,Ngoc Tran Minh,Hien Nguyen Thi Thu,Manh Hoang Duc,Lien Le Thi,Lee Ki Yong 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.6
Species belonging to the Vernonia (Asteraceae), the largest genus in the tribe Vernonieae (consisting of about 1,000 species), are widely used in food and medicine. These plants are rich sources of bioactive sesquiterpene lactones and steroid saponins, likely including many as yet undiscovered chemical components. A phytochemical investigation resulted in the separation of three new stigmastane-type steroidal saponins (1 – 3), designated as vernogratiosides A–C, from whole plants of V. gratiosa. Their structures were elucidated based on infrared spectroscopy (IR), one-dimensional (1D) and two-dimensional nuclear magnetic resonance (2D NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and electronic circular dichroism analyses (ECD), as well as chemical reactivity. Molecular docking analysis of representative saponins with αglucosidase inhibitory activity was performed. Additionally, the intended substances were tested for their ability to inhibit α-glucosidase activity in a laboratory setting. The results suggested that stigmastane-type steroidal saponins from V. gratiosa are promising candidate antidiabetic agents.
Determining the optimal range of vitamin C for early red drum (Sciaenops ocellatus) juveniles
Nguyen Thi Thuy,Khuong V. Dinh,Ngo Van Manh,Trung Si Trang 한국수산과학회 2023 Fisheries and Aquatic Sciences Vol.26 No.9
Vitamin C plays an important role for fish survival, growth and disease resistance. However, the optimal vitamin C for rearing red drum Sciaenops ocellatus juveniles in Vietnam is not known. To address this issue, a 70‐day feeding trial was conducted to evaluate the optimal dietary vitamin C requirements for red drum juveniles. Seven isonitrogenous (55.35% protein) and isolipidic (9.07% lipid) diets were formulated to include graded vitamin C concentrations of 23.2, 124.5, 235.2, 423.8, 626.7, 824.6, and 1,027.3 mg/kg, respectively. The results showed that fish fed on 423.8 mg/kg vitamin C diet had the highest growth rate, which can be linked to the increased feed utilization. Broken-line analysis indicated that the optimal dietary vitamin C requirements of red drum juveniles were 342.92 and 405.80 mg/kg for growth parameters, feed utilization, body composition and biochemical parameters of serum. Based on these parameters the optimal vitamin C supplementation level for red drum juveniles was estimated in the range of 342.92–405.80 mg/kg vitamin C in the diets with direct applications in producing artificial feed for rearing juveniles of this species in Vietnam.
Duyen Ha Thi Kim,Tien Ngo Manh,Cuong Nguyen Manh,Nhan Duc Nguyen,Dung Pham Tien,Manh Tran Van,Minh Phan Xuan 제어·로봇·시스템학회 2021 International Journal of Control, Automation, and Vol.19 No.4
The paper proposes the method to deal with control problems of unmodeled components of the fourwheeled Omni-directional mobile robot. It is commonly challenging to design a model-based control scheme to achieve smooth movement in the tracking process due to the unknown elements in the mathematical model of the robot or external disturbances. Our main contribution focuses on designing an adaptive controller based on neural networks with online weight updating laws and Fuzzy logic to guarantee the high accuracy of the robot’s movement when the unknown factors adversely affect the robot control. At the initial step, a Dynamic Surface Control plays a role as a core of the controller for the robot system. Then, with the ability to estimate the appropriate value for uncertain nonlinear parts, a Radial Basis Function Neural Network is designed. Finally, a Fuzzy law is to utilize control parameters in each period to increase the adaptive behavior of the system. The stability and convergence of the system are proven by the Lyapunov’s stability theory. The simulation results illustrate the validity and the efficiency of the proposed control algorithm when the system is lack of robot model’s information.