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Overexpression of the MUC1 Gene in Iranian Women with Breast Cancer Micrometastasis
Mansouri, Neda,Movafagh, Abolfazl,Soleimani, Shahrzad,Taheri, Mohammad,Hashemi, Mehrdad,Pour, Atefeh Heidary,Shargh, Shohreh Alizadeh,Mosavi-Jarahi, Alireza,Sasaninejad, Zahra,Zham, Hanieh,Hajian, Par Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3
The membrane epithelial mucin MUC1 is expressed at the luminal surface of most simple epithelial cells, but expression is greatly increased in most breast cancers. The aims of present study were to investigate expression of the MUC1 gene and interactive affects in metastases. Whole cell RNA isolation from 50 sentinel lymph nodes (SNLs) of breast cancer patients was performed using reverse transcription and real-time PCR. All patients were diagnosed with breast cancer and without metastasis, confirmed by IHC staining. The evaluation of tumor and normal samples for expression of MUC1 gene, the results were 49.1% non-expressive and 45.3% expression (Student t, p = 0.03). Also in comparison of normal breast tissue and breast cancer SLN for MUC1 gene, MUC1 negative SLNs were 75.0% (18 samples) and MUC1 positive samples were 25.0% (6 samples). Over-expression of MUC1 gene may offer a target for therapy related to progression and metastasis in women with breast cancer.
Evaluation of Factors Impacting Cosmetic Outcome of Breast Conservative Surgery - a Study in Iran
Olfatbakhsh, Asiie,Mehrdad, Neda,Ebrahimi, Mandana,Alavi, Nasrin,Hashemi, Esmat,Kaviani, Ahmad,Najafi, Masoume,Haghighat, Shahpar,Arefanian, Saeed Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
Background: Breast conservative surgery (BCS) followed by radiotherapy is the standard approach in management of stage I-II breast cancer. Several factors can affect cosmetic outcomes. The aim of this study was to evaluate the cosmetic results of BCS and influencing factors in the Iranian Breast Cancer Research Center. Materials and Methods: Patients who had undergone BCS were included. Photographs were taken of both breasts of the patients in three aspects and were evaluated by three specialists. The cosmetic scores were calculated based on a standard questionnaire. The data were analyzed using univariate and multivariate regression for relationships between cosmetic scores and clinical data. Results: A total number of 103 patients were included in the study. Mean age and BMI of the patients were $46.8{\pm}8.9$ and $28.1{\pm}3.9$, respectively. Breast cup sizes C and D accounted for 74.7% of the study group. The mean cosmetic score obtained from three referees was 5.72+2.06, consisting of 35.9% excellent-good, 35% moderate, and 29.1% unsatisfactory results. Patient BMI, volume of the resected tissue and breast cup size (D) showed significant correlation with the cosmetic score. On multivariate regression analysis, cosmetic score and BMI (p=0.022,) as well as breast cup size (p=0.040), remained significant. Conclusions: Immediate or delayed symmetrization of the breasts is suggested during breast conservative surgery, meanwhile performing oncoplastic techniques to improve the results significantly. Also it is suggested to discuss anticipation of less satisfactory results with patients having higher BMI and large breast cup size.
Zakaria Loloie,Mehrdad Mozaffarian,Mansooreh Soleimani,Neda Asassian 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.2
This research demonstrates the production of activated carbon from scrap tires via physical activation with carbon dioxide. A newly constructed apparatus was utilized for uninterrupted carbonization and activation processes. Taguchi experimental design (L16) was applied to conduct the experiments at different levels by altering six operating parameters. Carbonization temperature (550-700 oC), activation temperature (800-950 oC), process duration (30-120 min), CO2 flow rate (400 and 600 cc/min) and heating rate (5 and 10 oC/min) were the variables examined in this study. The effect of parameters on the specific surface area (SSA) of activated carbon was studied, and the influential parameters were identified employing analysis of variance (ANOVA). The optimum conditions for maximum SSA were: carbonization temperature=650 oC, carbonization time=60min, heating rate=5 oC/min, activation temperature= 900 oC, activation time=60min and CO2 flow rate=400 cc/min. The most effective parameter was activation temperature with an estimated impact of 49%. The activated carbon produced under optimum conditions was characterized by pore and surface structure analysis, iodine adsorption test, ash content, scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The process yield for optimized activated carbon was 13.2% with the following properties: specific surface area=437m2/g, total pore volume=0.353 cc/g, iodine number=404.7mg/g and ash content=13.9% along with an amorphous structure and a lot of oxygen functional groups. These properties are comparable to those of commercial activated carbons.
Spiritual Therapy in Coping with Cancer as a Complementary Medical Preventive Practice
Abolfazl Movafagh,Mohammad Hassan Heidari,Morteza Abdoljabbari,Neda Mansouri,Afsoon Taghavi,Aliasghar Karamatinia,Narjes Mehrvar,Mehrdad Hashemi,Mona Ghazi 대한암예방학회 2017 Journal of cancer prevention Vol.22 No.2
There are many of methods of treating cancer. However, the concept of curing the cancer is beyond our current knowledge. Some patients who have the cancer may seek an alternative manner of curing their disease. Alternative medicines, such as spiritual and complementary therapy, are able to cure the cancer and, at the least, are safe. Research on the importance of spirituality in cancer care has mainly been performed in geographically heterogeneous populations. The results are limited to these specific religious-cultural contexts and enlightened by contributions from ethnicity and religion. This article focused on the religiousness and spiritual support of cancer patients from diverse and heterogeneous groups around the globe. An electronic search of peer-reviewed articles was systematically performed to obtain the relevant literature with the CINAHL, PsycINFO, and PubMed databases. The keywords included religion, cancer, illness, psychotherapy, and spiritual and alternative treatment/therapies. The inclusion criteria for the reviews were that the documents were original quantitative research and published in English. Articles that were not directly relevant to the present objective were excluded. The present outcome of these review resources suggest that it may be helpful for clinicians to address spirituality, particularly with regard to prevention, healing, and survival of cancer patients. This article indicates that it may be useful for clinical oncologists to be informed of the prevalence of the use of spiritual medicine in their specialized field. In addition, patients should routinely be asked about the use of spiritual medicine as part of every cancer patient’s evaluation.
Yazdi, Hamid Reza,Movafagh, Abolfazl,Fallah, Fateme,Shargh, Shohreh Alizadeh,Mansouri, Neda,Pour, Atefeh Heidary,Hashemi, Mehrdad Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup3
It has been established that different kinds of bacteria agents are involved in various cancers. Although the mechanism of tumorigenesis is not clearly understood, there is evidence for the presence of bacteria within tumors, with at least a progression effect for some bacteria that prepare suitable microenvironments for tumor cell growth. The aim of current study was to evaluate bacterial dysbiosis in sentinel lymph nodes of breast cancer patients. One hundred and twenty three fresh-frozen sentinel lymph nodes and a corresponding number of normal adjacent breast tissue specimens and five normal mastectomy samples were investigated employing RT-PCR. In addition using genus-specific primers were applied. There was a significant differences as presence of Methylobacterium radiotolerance DNA recorded between patients and normal control group (p= 0.0). Based on our research work, further studies into the role of microbes in breast cancer would be of great interest.
Lack of Altered BECN1 Gene Expression in Iranian Patients with Acute Myeloid Leukemia
Keyvan, Ladan,Bidoki, Seyed Kazem,Abdollahi, Davood Zare,Mansouri, Neda,Hashemi, Mehrdad,Tabatabaei, SA Mortazavi,Fardmanesh, Hediyeh,Meimandi, Mansour,Ayatollahi, Seyed Majid,Movafagh, Abolfazl Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Acute myeloid leukemia (AML), one of the most prevalent leukemia types in adults, demonstrates great heterogeneity in molecular and clinical terms. Hence, there is a necessity to the mechanisms involved in AML generation in order to determine optimal treatment. This cross sectional study aimed to assess changes in BECN1 gene expression in with blood samples from 30 AML patients, compared with samples from 15 healthy persons. RNA was extracted and cDNA was synthesized and Real Time PCR applied to determine BECN1 gene expression. The results showed no significant differences in BECN1 gene expression between patients with AML and normal controls (P > 0.05). It appears that expression of BECN1 does not play a significant role in genesis of AML leukemia.