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Cho, Byoung Chul,Dy, Grace K.,Govindan, Ramaswamy,Kim, Dong-Wan,Pennell, Nathan A.,Zalcman, Gerard,Besse, Benjamin,Kim, Joo-Hang,Koca, Goekben,Rajagopalan, Prabhu,Langer, Simon,Ocker, Matthias,Nogai, Elsevier 2018 Lung cancer Vol.123 No.-
<P><B>Abstract</B></P> <P><B>Objectives</B></P> <P>This phase Ib/II study evaluated safety, pharmacokinetics, maximum tolerated dose (MTD), and efficacy of the pan-cyclin-dependent kinase inhibitor roniciclib with cisplatin-etoposide (CIS-ETOP) or carboplatin-etoposide (CARBO-ETOP) in patients with extensive-disease small-cell lung cancer (ED-SCLC).</P> <P><B>Patients and methods</B></P> <P>In this open-label, non-randomized study, patients with previously untreated ED-SCLC received roniciclib twice daily (BID) in a 3 days on/4 days off schedule. Cisplatin 75 mg/m<SUP>2</SUP> or carboplatin (AUC5) dose was administered on day 1, and etoposide 100 mg/m<SUP>2</SUP> on days 1–3, of 21-day cycles. Phase Ib used a dose-escalation design to define the MTD for phase II. Pharmacokinetics were assessed.</P> <P><B>Results</B></P> <P>Forty-three patients received treatment (roniciclib 2.5 mg BID [+ CARBO-ETOP, n = 4; + CIS-ETOP, n = 3] and roniciclib 5 mg BID [+ CARBO-ETOP, n = 24; + CIS-ETOP, n = 12]). The MTD of roniciclib was 5 mg BID with CARBO-ETOP or CIS-ETOP. Common adverse events were nausea (90.7%) and vomiting (69.8%). Roniciclib was readily absorbed following oral administration at the MTD (median t<SUB>max</SUB> 0.5–1 h), with a 30–40% reduction in exposure when co-administered with CARBO-ETOP or CIS-ETOP; administration of roniciclib had no effect on etoposide or platinum pharmacokinetics. The response rate was 81.4% (35/43) overall and 86.1% (31/36) in the pooled roniciclib 5 mg BID population (all partial responses).</P> <P><B>Conclusion</B></P> <P>Roniciclib co-administered with chemotherapy in patients with ED-SCLC demonstrated tolerability, acceptable pharmacokinetics, and promising efficacy. An observed safety signal in a related phase II study resulted in discontinuation of the present study and termination of further roniciclib development.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phase Ib/II study of ED-SCLC patients treated with roniciclib plus chemotherapy. </LI> <LI> Combination was well tolerated and readily absorbed across all dose combinations. </LI> <LI> No clinically relevant PK interactions were observed upon concomitant treatment. </LI> <LI> Promising efficacy of roniciclib plus chemotherapy, despite low patient numbers. </LI> <LI> Unfavorable benefit/risk balance from another study led to study termination. </LI> </UL> </P>
CAOTHILUYEN,Cho Nathan,이태헌,안성주,Lee Dong Ju,구양규 한국원예학회 2022 Horticulture, Environment, and Biotechnology Vol.63 No.6
The aim of this study was to determine the eff ect of diff erent cultivation systems on bioactive compounds, antioxidant enzymes, and anti-cancer activity of asparagus (Asparagus offi cinalis L.) spears grown in an open fi eld (OF) and a rain-shelter house (RSH) system at 19 months and 30 months after planting. The polyphenol, rutin, and p-coumaric acid contents and ABTS and DPPH radical scavenging activity of asparagus spears grown in the OF were higher than those of RSH spears. Antioxidant enzymes such as superoxide dismutase, ascorbate peroxidase, and peroxidase were higher in OF asparagus than in RSH asparagus. The survival rate of MCF-7 breast cancer cells treated with extracts of asparagus grown in an OF was lower than that of cells treated with RSH-grown asparagus extract, indicating that anticancer activity against the MCF-7 cancer cells of OF spears was higher than that of RSH spears. However, the fl avonoid, quercetin, sinapic acid, ferulic acid, and caff eic acid contents, catalase activity, and Calu-6 cell viability were not aff ected by cultivation system. For plants grown in the OF, rutin content in the 30-month-old plants was higher than that in the 19-month-old plants. These results indicate that asparagus spears grown in an OF have high levels of bioactive compounds, ABTS and DPPH radical scavenging activ- ity, and anticancer activities. Plant age did not aff ected total polyphenol and fl avonoid contents but it aff ected caff eic acid, rutin, and ferulic acid contents, DPPH radical scavenging activity, and anti-cancer activity against the lung cancer cell line. The correlations analysis revealed signifi cant positive correlations among the total phenolic and rutin contents, the ABTS and DPPH radical scavenging activities, the antioxidant enzyme activities (superoxide dismutase, peroxidase, and ascorbate peroxidase), and the anticancer activity
( Eun Jung Cho ),( Bok Yae Chung ),( Kwan Lee ),( Consedine Nathan S ),( Won Kee Lee ) 여성건강간호학회 2011 여성건강간호학회지 Vol.17 No.5
Purpose: Cervical cancer can be prevented by regular cervical screening. Embarrassment has been reported as one important barrier to cervical screening uptake. The absence of appropriate instrumentation, however, has limited our understanding of the links between embarrassment and health care outcomes. The purpose of this study was to evaluate psychometric attributes of the uterine cervical cancer screening embarrassment questionnaire. Methods: A convenience sample for field study was recruited from four gynecological clinics in Gyeongju, Korea. Within a cross-sectional descriptive design, 339 women who had cervical screening completed self-administered measures of embarrassment including a visual analogue, general medical embarrassment, dispositional embarrassment, and Pap smear related negative emotion. Results: Rasch analysis of items demonstrated the evidence of one-dimensional construct and good 7-point rating scales functioning. Factor analysis revealed that uterine cervical cancer screening embarrassment was comprised of two domains-bodily manifestations and perceiving an undesirable social face. Construct validity was demonstrated by a high subscale-to-subscale correlation. Convergent and discriminant validity was evidenced by significant correlations with a 100 mm VAS scale, general medical embarrassment, and Pap smear related negative emotion. Known-group validity was established by comparing women with high versus low trait embarrassment. Both two sub-scales and overall scale demonstrated good internal reliability. Conclusion: The Uterine uterine cervical cancer screening questionnaire is a reliable and valid instrument suited to assessing the manifestations of embarrassment during screening. The use of instrument can be extended to understand the client`s embarrassment undergoing health examinations which require the exposure of their private parts.
Decreasing biotoxicity of fume particles produced in welding process
Yu, Kuei-Min,Topham, Nathan,Wang, Jun,Kalivoda, Mark,Tseng, Yiider,Wu, Chang-Yu,Lee, Wen-Jhy,Cho, Kuk Elsevier 2011 Journal of hazardous materials Vol.185 No.2
<P><B>Abstract</B></P><P>Welding fumes contain heavy metals, such as chromium, manganese, and nickel, which cause respiratory diseases and cancer. In this study, a SiO<SUB>2</SUB> precursor was evaluated as an additive to the shielding gas in an arc welding process to reduce the biotoxicity caused by welding fume particles. Transmission electron micrographic images show that SiO<SUB>2</SUB> coats on the surface of welding fume particles and promotes particle agglomeration. Energy dispersive X-ray spectroscopy further shows that the relative amount of silicon in these SiO<SUB>2</SUB>-coated agglomerates is higher than in baseline agglomerates. In addition, <I>Escherichia coli</I> (<I>E. coli</I>) exposed to different concentrations of pure SiO<SUB>2</SUB> particles generated from the arc welding process exhibits similar responses, suggesting that SiO<SUB>2</SUB> does not contribute to welding fume particle toxicity. The trend of <I>E. coli</I> growth in different concentrations of baseline welding fume particle shows the most significant inhibition occurs in higher exposure concentrations. The 50% lethal logarithmic concentrations for <I>E. coli</I> in arc welding particles of baseline, 2%, and 4.2% SiO<SUB>2</SUB> precursor additives were 823, 1605, and 1800mg/L, respectively. Taken together, these results suggest that using SiO<SUB>2</SUB> precursors as an additive to arc welding shielding gas can effectively reduce the biotoxicity of welding fume.</P>