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- 저자 : Nannan Di (검색결과 2 건)
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Di Hu,Hui Zou,Tao Han,Junze Xie,Nannan Dai,Liling Zhuo,Jianhong Gu,Jianchun Bian,Yan Yuan,Xuezhong Liu,Zongping Liu 대한수의학회 2016 Journal of Veterinary Science Vol.17 No.1
Gap junctions mediate direct communication between cells; however, toxicological cascade triggered by nonessential metals can abrogate cellular signaling mediated by gap junctions. Although cadmium (Cd) is known to induce apoptosis in organs and tissues, the mechanisms that underlie gap junction activity in Cd-induced apoptosis in BRL 3A rat liver cells has yet to be established. In the present study, we showed that Cd treatment decreased the cell index (a measure of cellular electrical impedance) in BRL 3A cells. Mechanistically, we found that Cd exposure decreased expression of connexin 43 (Cx43), increased expression of p-Cx43 and elevated intracellular free Ca2+ concentration, corresponding to a decrease in gap junctional intercellular communication. Gap junction blockage pretreatment with 18b-glycyrrhizic acid (GA) promoted Cd-induced apoptosis, involving changes in expression of Bax, Bcl-2, caspase-3 and the mitochondrial transmembrane electrical potential (Δym). Additionally, GA was found to enhance ERK and p38 activation during Cd-induced activation of mitogen-activated protein kinases, but had no significant effect on JNK activation. Our results indicated the apoptosis-related proteins and the ERK and p38 signaling pathways may participate in gap junction blockage promoting Cd-induced apoptosis in BRL 3A cells.
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Jun Yu,Decai Li,Nannan Di,Ningning Guo 한국자기학회 2019 Journal of Magnetics Vol.24 No.2
The self-suspension of magnet in magnetic fluid has been widely used in micromechanical systems, sensors, and dampers. The magnetic field associated with the ring magnet is obtained by numerical calculation and simulation through which the axial magnetic levitation force is calculated, and the numerical calculation, simulation, and experimental results agree with each other. The influence of the radial eccentricity of the ring magnet on the axial magnetic levitation force is studied, the ring magnet will experience a maximum axial magnetic levitation force without radial eccentricity. With the increase of radial eccentricity and the decrease of the distance between the bottom of the ring magnet and container, the axial magnetic levitation force will continue to decrease. But it is worth noting that the magnitude of the change caused by radial eccentricity is negligible compared to that of the axial magnetic levitation force.
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