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( Namkwon Kim ),( Hyung-seok Yoo ),( Yeon-joo Ju ),( Myung Sook Oh ),( Kyung-tae Lee ),( Kyung-soo Inn ),( Nam-jung Kim ),( Jong Kil Lee ) 한국응용약물학회 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2
Neuroinflammation is an immune response within the central nervous system against various proinflammatory stimuli. Abnormal activation of this response contributes to neurodegenerative diseases such as Parkinson disease, Alzheimer’s disease, and Huntington disease. Therefore, pharmacologic modulation of abnormal neuroinflammation is thought to be a promising approach to amelioration of neurodegenerative diseases. In this study, we evaluated the synthetic flavone derivative 3’,4’-dihydroxyflavone, investigating its anti-neuroinflammatory activity in BV2 microglial cells and in a mouse model. In BV2 microglial cells, 3’,4’-dihydroxyflavone successfully inhibited production of chemokines such as nitric oxide and prostaglandin E2 and proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 in BV2 microglia. It also inhibited phosphorylation of mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB activation. This indicates that the anti-inflammatory activities of 3’,4’-dihydroxyflavone might be related to suppression of the proinflammatory MAPK and NF-κB signaling pathways. Similar anti-neuroinflammatory activities of the compound were observed in the mouse model. These findings suggest that 3’,4’-di-hydroxyflavone is a potential drug candidate for the treatment of microglia-related neuroinflammatory diseases.
Kim, Namkwon,Yoo, Hyung-Seok,Ju, Yeon-Joo,Oh, Myung Sook,Lee, Kyung-Tae,Inn, Kyung-Soo,Kim, Nam-Jung,Lee, Jong Kil The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.2
Neuroinflammation is an immune response within the central nervous system against various proinflammatory stimuli. Abnormal activation of this response contributes to neurodegenerative diseases such as Parkinson disease, Alzheimer's disease, and Huntington disease. Therefore, pharmacologic modulation of abnormal neuroinflammation is thought to be a promising approach to amelioration of neurodegenerative diseases. In this study, we evaluated the synthetic flavone derivative 3',4'-dihydroxyflavone, investigating its anti-neuroinflammatory activity in BV2 microglial cells and in a mouse model. In BV2 microglial cells, 3',4'-dihydroxyflavone successfully inhibited production of chemokines such as nitric oxide and prostaglandin $E_2$ and proinflammatory cytokines such as tumor necrosis factor alpha, interleukin 1 beta, and interleukin 6 in BV2 microglia. It also inhibited phosphorylation of mitogen-activated protein kinase (MAPK) and nuclear factor $(NF)-{\kappa}B$ activation. This indicates that the anti-inflammatory activities of 3',4'-dihydroxyflavone might be related to suppression of the proinflammatory MAPK and $NF-{\kappa}B$ signaling pathways. Similar anti-neuroinflammatory activities of the compound were observed in the mouse model. These findings suggest that 3',4'-dihydroxyflavone is a potential drug candidate for the treatment of microglia-related neuroinflammatory diseases.
Jonghyo Lee,Namkwon Lee,Sukkee Um 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.8
A three-dimensional thermofluidic model was developed for simulating fluid flow and heat transfer in interior permanent magnet synchronous motors (IPMSMs) with internal air circulation for effective thermal management. Protrusion-shaped flow inducers were introduced to facilitate the internal air circulation through rotor ventilation holes, increasing convection and preventing temperature rises in primary motor components. The numerical model agreed well with the experimental data. Subsequently, various geometrical design variables of the protrusion were selected to determine the thermofluidic characteristics of the electric motor associated with local temperature distributions for critical motor components. The protrusion increased the mass flow into the ventilation holes; accordingly, the maximal rotor temperature was inversely proportional to the protrusion design. Additionally, a thin airgap between the stator and rotor affected the radial heat transfer rate by forming additional thermal resistance layers. This flow was modeled using the Taylor-Couette paradigm, with the relative error under 1 %.
유비쿼터스 기반 텔레매틱스 단말 소프트웨어 아키텍처 연구
정남권(Namkwon Jung),이종근(Jongkeun Lee),이동훈(Donghun Lee) 한국자동차공학회 2004 한국자동차공학회 춘 추계 학술대회 논문집 Vol.- No.-
We are in the personal computing era, person and machine communicating through the computer that sits on lop of the desk. Next comes the third paradigm computing, ubiquitous computing, when technology recedes into the background of our lives. This paper presents the telematics software architecture which opens in-vehicle network to the broader network infrastructure of the outside by adopting Ubiquitous Computing to the electronics of vehicle. The proposed architecture is composed of OSGi (Open Service Gateway Initiative) and a number of layers based on Java technology, emphasizing the open aspect of the ubiquitous network. It also guides the way into which telematics develops in accordance with the realization of Ubiquitous Technology.
상사성 원리를 이용한 복식 압력 용기 열 유동 전산해석
이남권(Namkwon Lee),이종효(Jonghyo Lee),엄석기(Sukkee Um) 대한기계학회 2017 대한기계학회 춘추학술대회 Vol.2017 No.11
In this study, a computational model based on similarity analysis is proposed to simulate the steam generation phenomena and the inflow pattern of Deionized water(DIW) of the multi-vessel steam generator. Similarity analysis is performed to reduce computation time of multi-vessel steam generator model. Multi-vessel with similarity analysis predicts the possible problems that can occur during the heater malfunction of a pressure vessel. Moreover, two different inflow types of DIW pipeline configurations are compared to find out the best uniform distribution of DIW to all pressure vessels. These results show that the heater malfunction causes the steam flows from normal operating pressure vessels to a malfunctioning pressure vessel. In addition, the results show that the cascade inflow type of DIW pipeline can uniformly supply DIW to all pressure vessels better than parallel inflow type of DIW pipeline.