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Heungsup Sung,Kyoung Ho Roh,Ki Ho Hong,성문우,Namhee Ryoo,Hyun Soo Kim,Jaehyeon Lee,So Yeon Kim,Sookwon Yoo,Mi-Na Kim,Myung-Guk Han,Sang Won Lee,Hyukmin Lee,Cheon Kwon Yoo 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.6
Coronavirus disease 2019 (COVID-19) is a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Early detection of COVID-19 and immediate isolation of infected patients from the naive population are important to prevent further pandemic spread of the infection. Real-time reverse transcription (RT)-PCR to detect SARS-CoV-2 RNA is currently the most reliable diagnostic method for confirming COVID-19 worldwide. Guidelines for clinical laboratories on the COVID-19 diagnosis have been recently published by Korean Society for Laboratory Medicine and the Korea Centers for Disease Control and Prevention. However, these formal guidelines do not address common practical laboratory issues related to COVID-19 real-time RT-PCR testing and their solutions. Therefore, this guideline is intended as a practical and technical supplement to the “Guidelines for Laboratory Diagnosis of COVID-19 in Korea”.
Regional TMPRSS2 V197M Allele Frequencies Are Correlated with COVID-19 Case Fatality Rates
Jeon, Sungwon,Blazyte, Asta,Yoon, Changhan,Ryu, Hyojung,Jeon, Yeonsu,Bhak, Youngjune,Bolser, Dan,Manica, Andrea,Shin, Eun-Seok,Cho, Yun Sung,Kim, Byung Chul,Ryoo, Namhee,Choi, Hansol,Bhak, Jong Korean Society for Molecular and Cellular Biology 2021 Molecules and cells Vol.44 No.9
Coronavirus disease, COVID-19 (coronavirus disease 2019), caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), has a higher case fatality rate in European countries than in others, especially East Asian ones. One potential explanation for this regional difference is the diversity of the viral infection efficiency. Here, we analyzed the allele frequencies of a nonsynonymous variant rs12329760 (V197M) in the TMPRSS2 gene, a key enzyme essential for viral infection and found a significant association between the COVID-19 case fatality rate and the V197M allele frequencies, using over 200,000 present-day and ancient genomic samples. East Asian countries have higher V197M allele frequencies than other regions, including European countries which correlates to their lower case fatality rates. Structural and energy calculation analysis of the V197M amino acid change showed that it destabilizes the TMPRSS2 protein, possibly negatively affecting its ACE2 and viral spike protein processing.
Guidelines for Laboratory Diagnosis of Coronavirus Disease 2019 (COVID-19) in Korea
Ki Ho Hong,Sang Won Lee,Taek Soo Kim,Hee Jae Huh,Jaehyeon Lee,So Yeon Kim,Jae-Sun Park,Gab Jung Kim,Heungsup Sung,Kyoung Ho Roh,Jae-Seok Kim,Hyun Soo Kim,Seung-Tae Lee,성문우,Namhee Ryoo,Hyukmin Lee,Kye- 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.5
The outbreak of coronavirus disease 2019 (COVID-19), which began in December 2019, is still ongoing in Korea, with >9,000 confirmed cases as of March 25, 2020. COVID-19 is a severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection, and real-time reverse transcription-PCR is currently the most reliable diagnostic method for COVID-19 around the world. Korean Society for Laboratory Medicine and the Korea Centers for Disease Prevention and Control propose guidelines for diagnosing COVID-19 in clinical laboratories in Korea. These guidelines are based on other related domestic and international guidelines, as well as expert opinions and include the selection of test subjects, selection of specimens, diagnostic methods, interpretation of test results, and biosafety.