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Impact of Family History on Prognosis of Patients with Sporadic Colorectal Cancer
Lee, Soo Young,Kim, Duck-Woo,Kang, Sung Il,Ihn, Myong Hoon,Oh, Heung-Kwon,Kang, Sung-Bum,Kim, Chang Hyun,Kim, Hyeong Rok,Kim, Young Jin,Ju, Jae Kyun Springer - Society of Surgical Oncology 2019 Annals of Surgical Oncology Vol.26 No.4
Risk of osteoporosis and fracture in long-term breast cancer survivors
Jieon Go,Su Yeon Park,김경식,Min Chang Kang,Myong Hoon Ihn,윤상철,Sang Hyun Kim,Sunghoon Hong,이종은,한선욱,김성용,Zisun Kim,허성모,이지현 대한종양외과학회 2020 Korean Journal of Clinical Oncology Vol.16 No.1
Purpose: High incidence of osteoporosis has been reported in breast cancer patients due to early menopause triggered by adjuvant treatment and temporary ovarian function suppression. In this study, we sought to determine whether long-term breast cancer survivors had an elevated risk of low bone density compared to the general population. Methods: Long-term breast cancer survivors who had been treated for more than 5 years were selected for this study. Data were obtained from medical records and using a questionnaire from the Korea National Health and Nutrition Examination Survey (KNHANES). An agematched non-cancer control group was selected from the KNHANES records. Incidence of fracture and bone mineral density (BMD) were compared between the two groups. Results: In total, 74 long-term breast cancer survivors and 296 non-cancer controls were evaluated. The incidence of fracture did not differ between the two groups (P=0.130). No differences were detected in lumbar BMD (P=0.051) following adjustment for body mass index, while hip BMD was significantly lower in breast cancer survivors (P=0.028). Chemotherapy and endocrine treatment were not related to low BMD in breast cancer survivors. In more than half of the survivors, the 10-year risk of osteoporotic fracture was less than 1%. Conclusion: Long-term breast cancer survivors had low bone density but a comparable risk of fracture compared to non-cancer agematched controls. Further studies on the factors related to low bone density in long-term breast cancer survivors are required
Low-Level Microsatellite Instability as a Potential Prognostic Factor in Sporadic Colorectal Cancer
Lee, Soo Young,Kim, Duck-Woo,Lee, Hye Seung,Ihn, Myong Hoon,Oh, Heung-Kwon,Min, Byung Soh,Kim, Woo Ram,Huh, Jung Wook,Yun, Jung-A.,Lee, Kang Young,Kim, Nam Kyu,Lee, Woo Yong,Kim, Hee Cheol,Kang, Sung- Wolters Kluwer Health 2015 Medicine Vol.94 No.50
<P><B>Abstract</B></P><P>Although microsatellite instability-high (MSI-H) colorectal cancers (CRCs) have been shown to exhibit a distinct phenotype, the clinical value of MSI-low (MSI-L) in CRC remains unclear. We designed this study to examine the clinicopathologic characteristics and oncologic implications associated with MSI-L CRCs.</P><P>We retrospectively reviewed data of CRC patients from 3 tertiary referral hospitals in Korea, who underwent surgical resection between January 2003 and December 2009 and had available MSI testing results. MSI testing was performed using the pentaplex Bethesda panel. Clinicopathologic features and oncologic outcomes were compared between MSI-L and microsatellite stable (MSS) CRCs; prognostic factors for survival were also examined.</P><P>Of the 3019 patients reviewed, 2621 (86.8%) were MSS, and 200 (6.6%) were MSI-L; the remaining 198 (6.6%) were MSI-H. MSI-L and MSS CRCs were comparable in terms of their clinicopathologic features, with the exception of proximal tumor location (MSI-L 30.0% vs MSS 22.1%, <I>P</I> = 0.024) and tumor size (MSI-L 5.2 ± 2.6 cm vs MSS 4.6 ± 2.1 cm, <I>P</I> = 0.001). No differences were detected in either 3-year disease-free survival (MSI-L 87.2% vs MSS 82.6%, <I>P</I> = 0.121) or 5-year overall survival (OS) (MSI-L 74.2% vs MSS 78.3%, <I>P</I> = 0.131) by univariable analysis. However, MSI-L was an independent prognostic factor for poor OS by Cox regression analysis (hazard ratio 1.358, 95% confidence interval 1.014–1.819, <I>P</I> = 0.040).</P><P>MSI-L may be an independent prognostic factor for OS in sporadic CRCs despite their clinicopathologic similarity to MSS. Further studies investigating the significance of MSI-L in the genesis and prognosis of CRCs are needed.</P>
Low-level Microsatellite Instability as a Potential Prognostic Factor in Sporadic Colorectal Cancer
Soo Young Lee,Duck-Woo Kim,Hye Seung Lee,Myong Hoon Ihn,Heung-Kwon Oh,Kang Young Lee,Byung Soh Min,Woo Rim Kim,Hee Cheol Kim,Jung Wook Huh,Jung-A Yun,Sung-Bum Kang 대한종양외과학회 2015 대한임상종양학회 학술대회지 Vol.2015 No.2
Lee, Yoon Hyun,Oh, Heung-Kwon,Kim, Duck-Woo,Ihn, Myong Hoon,Kim, Jee Hyun,Son, Il Tae,Kang, Sung Il,Kim, Gwang Il,Ahn, Soyeon,Kang, Sung-Bum The Korean Society of Coloproctology 2016 Annals of Coloproctolgy Vol.32 No.5
<P><B>Purpose</B></P><P>This study was conducted to identify the effectiveness of a preoperative comprehensive geriatric assessment (CGA) for predicting postoperative morbidity in elderly patients who underwent surgery for colorectal cancer.</P><P><B>Methods</B></P><P>Elderly patients (≥70 years old) who underwent surgery for colorectal cancer at a tertiary hospital in Korea were identified, and their cases were analyzed using data from a prospectively collected database to establish an association between major postsurgical complications and 'high-risk' patient as defined by the CGA.</P><P><B>Results</B></P><P>A total of 240 patients, with a mean age of 76.7 ± 5.2 years, were enrolled. Ninety-five patients (39.6%) were classified as 'high-risk' and 99 patients (41.3%) as having postoperative complications. The univariate analysis indicated that risk factors for postoperative complications were age, American Society of Anesthesiologists physical status classification, serum hemoglobin, carcinoembryonic antigen, cancer stage, and 'high-risk' status. The multivariable analyses indicated that 'high-risk' status (odds ratio, 2.107; 95% confidence interval, 1.168–3.804; P = 0.013) and elevated preoperative carcinoembryonic antigen (odds ratio, 2.561; 95% confidence interval, 1.346–4.871, P = 0.004) were independently associated with postoperative complications. A multivariable analysis of the individual CGA domains indicated that high comorbidities and low activities of daily living were significantly related with postoperative complications.</P><P><B>Conclusion</B></P><P>A preoperative CGA indicating 'high-risk' was associated with major postoperative complications in elderly patients who underwent surgery for colorectal cancer. Thus, using the CGA to identify elderly colorectal-cancer patients who should be given more care during postoperative management may be clinically beneficial.</P>