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RISS 인기검색어
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- 저자 : Mona E. Ibrahim (검색결과 2 건)
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E. Abdelmegeed,Mona Ibrahim Shaaban 한국미생물학회 2013 The journal of microbiology Vol.51 No.5
The incidence of fluconazole-resistant Candida albicans has been increasing worldwide. Both biofilm and fungal morphogenesis are main virulence factors of C. albicans cells. Extracellular fungal prostaglandins are synthesized during biofilm adhesion and development and through yeast-hypha conversion. Hence, we targeted prostaglandin synthesis with various cyclooxygenase (COX) inhibitors (aspirin, diclofenac,ketoprofen, tenoxicam, and ketorolac) and assessed their effect on fungal adhesion, biofilm formation, and yeast-hypha conversion in clinical isolates of Fluconazole resistant C. albicans. Significant reduction in fungal adhesion and detachment of mature biofilm was attained down to 1 mM concentrations of anti-inflammatory agents. Microscopical examination of fungal cells in the presence of the tested drugs showed significant reduction of germ tube formation. Therefore,COX inhibitors have a significant effect on reduction of Candida adhesion and biofilm development in correlation with fungal morphogenesis. Moreover, inhibition of C. albicans by COX inhibitors gave synergistic activity with fluconazole suggesting that combination therapeutic strategies may be fruitful for management of infection of Fluconazole resistant C. albicans.
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Elsayed M. Abdel Bary,Ammar N. Harmal,Mona E. Ibrahim,Moustafa A. Gouda 한국섬유공학회 2020 Fibers and polymers Vol.21 No.12
Novel chitosan nanoparticles (SCN) were synthesized via reaction of chitosan with different concentration of 2-chloro-N-(3-methylisoxazol-5-yl) acetamide (5 %, 10 % and 15 %) at 70-80 oC for 7 h to give the grafted polymer, whichcondensed with cyclohexanone Mannich base 45 oC for 7 h to afford the corresponding (SCN). These were stirred withDeflazacort drug to achieve the Deflazacort loading (SCN), which, compressed with calcium starch glycolate (CaSgly) togive the corresponding tablets. The pH 2. 1 and concentration of SCN-10 %/CaSgly (1:4) was found to be importantparameters in controlling the release profiles.
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