The Association of COVID-19 and Reactive Oxygen Species Modulator 1 (ROMO1) with Oxidative Stress

Mohammad Amin Amini,Jamshid Karimi,Seyed Saman Talebi,Hosein Piri 전남대학교 의과학연구소 2022 전남의대학술지 Vol.58 No.1

There is no denying that the massive spread of COVID-19 around the world has worried everyone. The virus can cause mild to severe symptoms in various organs, especially the lungs. The virus affects oxidative stress in the cells. Reactive Oxygen Species modulator 1 (ROMO1) is one of the most important mitochondrial proteins that plays a critical regulatory role in the production of Reactive Oxygen Species (ROS). According to the studies, COVID-19 can promote oxidative stress through some important pathways, for instance, TNF-a and NF-kB routes. Furthermore, ROMO1 is closely related to these pathways and its dysfunction may affect these routes, then promote oxidative stress, and ultimately cause tissue damage, especially in the lungs. Another factor to consider is that the TNF-a and NF-kB pathways are associated with ROMO1, COVID-19, and oxidative stress. To summarize, it is hypothesized that COVID-19 may increase oxidative stress by affecting ROMO1. Understanding the exact molecular mechanisms of ROMO1 in the pathogenesis of COVID-19 can pave the way to find better therapeutic strategies.

Mechanistic Insight into Age-Related Macular Degeneration (AMD): Anatomy, Epidemiology, Genetics, Pathogenesis, Prevention, Implications, and Treatment Strategies to Pace AMD Management

Mohammad Amin Amini,Ashkan Karbasi,Mohammad Vahabirad,Masoud Khanaghaei,Aida Alizamir 전남대학교 의과학연구소 2023 전남의대학술지 Vol.59 No.3

One of the most complicated eye disorders is age-related macular degeneration (AMD) which is the leading cause of irremediable blindness all over the world in the elderly. AMD is classified as early stage to late stage (advanced AMD), in which this stage is divided into the exudative or neovascular form (wet AMD) and the nonexudative or atrophic form (dry AMD). Clinically, AMD primarily influences the central area of retina known as the macula. Importantly, the wet form is generally associated with more severe vision loss. AMD has a systemic component, where many factors, like aging, genetic, environment, autoimmune and non-autoimmune disorders are associated with this disease. Additionally, healthy lifestyles, regular exercise, maintaining a normal lipid profile and weight are crucial to decreasing the risk of AMD. Furthermore, therapeutic strategies for limiting AMD should encompass a variety of factors to avoid and improve drug interventions, and also need to take into account personalized genetic information. In conclusion, with the development of technology and research progress, visual impairment and legal blindness from AMD have been substantially reduced in incidence. This review article is focused on identifying and developing the knowledge about the association between genetics, and etiology with AMD. We hope that this review will encourage researchers and lecturers, open new discussions, and contribute to a better understanding of AMD that improves patients’ visual acuity, and upgrades the quality of life of AMD patients.

Reactive Oxygen Species Modulator 1 (ROMO1), a New Potential Target for Cancer Diagnosis and Treatment

Mohammad Amin Amini,Seyed Saman Talebi,Jamshid Karimi 전남대학교 의과학연구소 2019 전남의대학술지 Vol.55 No.3

Today, the incidence of cancer in the world is rising, and it is expected that in the next several decades, the number of people suffering from cancer or (the cancer rate) will double. Cancer is defined as the excessive and uncontrolled growth of cells; of course (in simple terms), cancer is considered to be a set of other diseases that ultimately causes normal cells to be transformed into neoplastic cells. One of the most important causes of the onset and exacerbation of cancer is excessive oxidative stress. One of the most important proteins in the inner membrane of mitochondria is Reactive Oxygen Species (ROS) Modulator 1 (ROMO1) that interferes with the production of ROS, and with increasing the rate of this protein, oxidative stress will increase, which ultimately leads to some diseases, especially cancer. In this overview, we use some global databases to provide information about ROMO1 cellular signaling pathways, their related proteins and molecules, and some of the diseases associated with the mitochondrial protein, especially cancer.

The Association of Oxidative Stress and Reactive Oxygen Species Modulator 1 (ROMO1) with Infertility: A Mini Review

Mohammad Amin Amini,Masoud Karimi,Seyed Saman Talebi,Hossein Piri,Jamshid Karimi 전남대학교 의과학연구소 2022 전남의대학술지 Vol.58 No.3

Infertility is one of the disorders that worries many couples around the world, although novel and molecular methods can be used to cure this disease in different stages. One of the factors that causes infertility in men and women is the increased oxidative stress within the cells, which can lead to damage in zygote formation. ROMO1 is one of the most important proteins in the production of reactive oxygen species. This protein can enhance oxidative stress in the cells and body through cellular pathways, such as TNF-a and NF-kB routes, which will eventually lead to many diseases, especially infertility. We engage several international databases by using keywords; ROMO1, Infertility, and Reactive Oxygen Species, and gained a great quantity of information about ROMO1, Infertility, and Oxidative Stress. Although not proven, it is hypothesized that ROMO1 might elevate oxidative stress by activating NF-kB pathway in the cells, furthermore, TNF-a can arouse ROMO1 that can end up with apoptosis and cell death, which consequently can have a lot of disturbing effects on the body, especially the reproductive system. To sum up, revealing the exact cellular and molecular mechanisms of ROMO1-dependent TNF-a and NF-kB pathways in the pathogenesis of infertility might find interesting therapeutic and management strategies for this disorder.

Soft Switching Three Phase Inverter with Two Auxiliary Switches

Mohammad Mahdavi,Mohammad Reza Amini,Amin Emrani,Hosein Farzanehfard 전력전자학회 2011 JOURNAL OF POWER ELECTRONICS Vol.11 No.6

In this paper, a new three phase soft switching inverter is presented. All of the semiconductor elements of this converter are soft switched. Employing only two auxiliary switches as DC-link switches and a simple control circuit are the advantages of the proposed inverter. The analytical equations and operating modes of the presented inverter are explained in details. The design considerations are presented and the experimental results verify the theoretical analysis.

Soft Switching Three Phase Inverter with Two Auxiliary Switches

Mahdavi, Mohammad,Amini, Mohammad Reza,Emrani, Amin,Farzanehfa, Hosein The Korean Institute of Power Electronics 2011 JOURNAL OF POWER ELECTRONICS Vol.11 No.6

In this paper, a new three phase soft switching inverter is presented. All of the semiconductor elements of this converter are soft switched. Employing only two auxiliary switches as DC-link switches and a simple control circuit are the advantages of the proposed inverter. The analytical equations and operating modes of the presented inverter are explained in details. The design considerations are presented and the experimental results verify the theoretical analysis.

Diameter Measurement of Jet-Grouting Column Using Geo-Electrical Probe: Construction and Field Testing

Abolfazl Amini,Mahdi Rojhani,Asghar Azadi,Mohammad Amin Raoof 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.2

Uncertainty about the geometry of jet grouting columns is a serious challenge to the efficiency of jet grouting technology. If this challenge can be met, jet grouting can become an efficient method of soil improvement. One proposed approach is measurement based on changes in the electrical resistivity between the column and surrounding soil. This approach is non-destructive, easy to use, fast and accurate. This paper reviews jet-grouting methods using the experimental research approach and reports on the design and construction of a probe equipped with ring electrodes that is suitable for measurement of the column diameter. The approach is based on the geoelectric method and Wenner theory. The probe was field tested on jet-grouting columns in a project in Bandar-e Gaz. The probe results were validated by visually observing the dimensions of the excavated column. The results showed that the probe performed well. The device measured a 90-cm column as being from 81 to 88 cm with an error of about 10%. The method of measuring the difference in electrical resistance was shown to be an accurate approach to solving the problem of uncertainty in the geometry of jet-grouting columns.

MiR-4492, a New Potential MicroRNA for Cancer Diagnosis and Treatment: A Mini Review

Aida Alizamir,Mohammad Amin Amini,Ashkan Karbasi,Mehdi Beyrami 전남대학교 의과학연구소 2024 전남의대학술지 Vol.60 No.1

There is no doubt that the incidence of cancer sufferers is rising in the world, and it is estimated that in the next several decades, the number of people suffering from malignancies or the cancer rate will double. Diagnostic and therapeutic targeting of noncoding RNAs (ncRNAs), especially microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represent an excellent approach for cancer diagnosis and treatment, as well as many other diseases. One of the latest miRNAs is miR-4492, upregulating some genes in tumor tissues including ROMO1, HLA-G, NKIRAS2, FOXK1, and UBE2C. It represents an attractant example of a miRNA acting at multiple levels to affect the same malignancy hallmark. Based on the studies, miR-4492 plays a key role in several cancers such as, breast cancer, bladder cancer, osteosarcoma, glioblastoma multiforme, hepatocellular carcinoma, colorectal cancer, and ovarian cancer. Putting it all together, identifying the precise mechanisms of miR-4492 in the pathogenesis of cancer, could pave the way to find better diagnostic and therapeutic strategies for cancer sufferers. For this reason, it might be a novel potential diagnostic biomarker and therapeutic target for neoplasms.

Overexpression of miR-146a and miR-155 are Potentially Biomarkers and Predict Unfavorable Relationship between Gastric Cancer and Helicobacter pylori Infection

Masoud Karimi,Abdolreza Mohammadnia,Mohammad Amin Amini,Azar Ghavimi Shamekh,Elahe Derakhshanfar,Farzaneh Hosseini 전남대학교 의과학연구소 2023 전남의대학술지 Vol.59 No.3

Gastric Cancer (GC) is one of the most dangerous malignancies in the world. This study aims to evaluate the relationship between miR-146a and miR-155 in patients with H. pylori infections with GC compared to H. pylori-infected patients and healthy subjects. Forty patients with H. pylori and GC positive diagnoses and 40 patients with H. pylori positive and GC negative diagnoses, and 40 healthy persons were selected. The expression of miR-146a and miR-155 genes in the whole blood was examined using qRT-PCR. Moreover, ROC curves were drawn to represent the sensitivity and specificity of miR-146a and miR-155 expression as biomarkers. The results showed the expression of miR-146a and miR-155 in the whole blood of patients with H. pylori and GC positive diagnoses are significantly higher than in healthy individuals and are non-significantly enhanced compared to H. pylori positive and GC negative. Also, the results stated miR-146a and miR-155 expression in the whole blood of patients who are H. pylori positive and GC negative are significantly increased compared to healthy individuals. Furthermore, the ROC curve analysis of miR-146a and miR-155 RNA level demonstrated the two miRNAs have an appropriate sensitivity and specificity for diagnostic goals. In conclusion, H. pylori infection may increase the expression of miR-146a and miR-155 in patients with H. pylori and GC positive diagnoses, which can be effective in the curbing the progression of GC. For this reason, up-regulation of miR-146a and miR-155 along with H. pylori infection might contribute to the pathogenesis of GC, and also can be suggested as biomarkers for GC diagnosis and treatment.