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- 검색키워드
- 저자 : Mohamed Abd- El Salam (검색결과 4 건)
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El Nemr Esmail, Reham Shehab,El Farouk Abdel-Salam, Lubna Omer,Abd El Ellah, Mohammed M Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10
Background: Prognostic biomarkers in breast cancer are routinely investigated in the primary tumors to guide further management. However, it is proposed that the expression may change during the disease progression, and may result in a different immune profile in the metastatic nodes. This work aimed to investigate the expression of breast prognostic biomarkers in primary tumors and in its axillary nodal metastasis, to estimate the possible discordant expression. Materials and Methods: 60 paired primary and axillary nodal metastasis samples were collected from patients with primary breast cancer with positive nodal deposits, diagnosed at the Maadi Military Hospital, Cairo, Egypt, during the year 2013. ER, PR and HER2 expression was assessed by immunohistochemistry in all samples Results: 48.3% of the included cases showed concordant results for both ER and PR receptors between the primary tumor and its nodal metastasis while 51.7% showed discordant results and the discordance level was statistically significant. On the other hand, 70% of the cases showed concordant Her2 results between the primary tumors and the nodal deposits, 30% showed discordant results and the difference was significant. Conclusions: The study indicated that the discordance in ER and PR receptor expression between the primary breast tumor and their nodal metastasis may be significant. The possible switch in the biomarker status during the disease progression is worth noting and may change the patient therapeutic planning. So, whether the treatment selection should be based on biomarkers in the lymph node is a topic for further studies and future clinical trials.
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Hayam A. Abd El Salam,Mohamed S. Abdel‑Aziz,Eslam Reda El‑Sawy,Elkhabiry Shaban 한국섬유공학회 2023 Fibers and polymers Vol.24 No.8
For conjugating sulfa drug moieties with Schiff’s bases scaffold in the same build through an azo linker to take advantage of the bioactive feature of both motifs, we designed and synthesized a series of bioactive disperse dyes. The target disperse dyes, methyl 2-(E-2-hydroxy-5-((E)-(4-sulfa-derivative) diazenyl)benzylidene) hydrazine-1-carbodithioates 4a–e have been synthesized via the acidic reaction of azo dyes 3a–e with methyl hydrazine carbodithioate. Structures of the synthesized dyes were clarified based on their spectral and elemental analyses. The effectiveness of the dyes was initially tested as an antibacterial toward Staphylococcus aureus ATCC 6538-P and Escherichia coli ATCC 25933. Dyes that were proven to be effective against bacteria have been used as disperse dyes to print polyester fabrics. The color properties of the dyes and their fastness properties counting washing, perspiration, light, rubbing, and sublimation fastness were also examined. The printed polyester fabrics were evaluated for their antibacterial activity via colony-forming unit (CFU) technique. Fabric samples treated with 4c, 4d, and 4b had promising anti-Gram-positive activities against S. aureus. Whereas 4c-, 4d-, and 4b-treated fabrics exhibited moderate anti-Gram-negative activities against the test bacterium E. coli.
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H. Abdel-Khalek,Mohamed Abd- El Salam,Fatma M. Amin 한국물리학회 2019 Current Applied Physics Vol.19 No.4
In this work, the optoelectronic performance of organic/inorganic heterojunction photodiode based on alphasexithiophene (α-6T/n-Si) is introduced. A thin film of α-6T was deposited on the n-type silicon substrate by a thermal evaporation technique. The topographical properties of the α-6T thin film grown on the n-Si substrate were investigated using a field emission scanning electron microscope (FESEM) technique. A network of nanocrystalline needles over the film surface was observed which give rise to an improvement in the electric charge transport. The optical properties of the prepared thin film were investigated using a spectrophotometric technique. The high absorption of α-6T in UV and visible region suggested the ability of this architecture for UV and visible light detection. The I-V characteristics of the fabricated photodiode were investigated in dark and under different illumination intensities and different wavelengths. The present architecture showed a good response to halogen lamb light, where the estimated values of rising and falling time at 160 mW/cm2 were about 400 ms and 450 ms, respectively. The results show the possibility of using Au/α-6T/n-Si/Al structure as a photodetector for a wide range of the solar spectrum (UV–Visible).
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H. Abdel-Khalek,M.I. El-Samahi,Mohamed Abd- El Salam,Ahmed M. El-Mahalawy 한국물리학회 2018 Current Applied Physics Vol.18 No.12
Organic/inorganic ultraviolet photodetector was fabricated using thermal evaporation technique. Organic/inorganic heterojunction based on thermally evaporated copper (II) acetylacetonate thin film of thickness 200 nm deposited on an n-type silicon substrate is introduced. I–V characteristics of the fabricated heterojunction were investigated under UV illumination of intensity 65 mW/cm2. The diode parameters such as ideality factor, n, barrier height, ΦB, and reverse saturation current, Is, were determined using thermionic emission theory. The series resistance of the fabricated diode was determined using modified Nord's method. The estimated values of series resistance and barrier height of the diode were about 0.33 KΩ and 0.72 eV, respectively. The fabricated photodetector exhibited a responsivity and specific detectivity about 9 mA/W and 4.6×109 Jones, respectively. The response behavior of the fabricated photodetector was analyzed through ON-OFF switching behavior. The estimated values of rise and fall time of the present architecture under UV illumination were about 199 ms and 154 ms, respectively. Finally, enhancing the photoresponsivity of the fabricated photodetector, post-deposition plasma treatment process was employed. A remarkable modification of the device performance was noticed as a result of plasma treatment. These modifications are representative in a decrease of series resistance and an increase of photoresponsivity and specific detectivity. The process of plasma treatment achieved an increment of external quantum efficiency from 5.53% to 8.34% at −3.5 V under UV illumination.
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