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Dynamics of a Mobile RNA of Potato Involved in a Long-Distance Signaling Pathway[W],[OA]
Anjan K. Banerjeea,Mithu Chatterjeea,Yueyue Yua,b,Sang-Gon Suhc,W. Allen Millerb,David J. Hannapela,1 한국작물학회 2007 한국작물학회 학술발표대회 논문집 Vol.2007 No.11
BEL1-like transcription factors interact with Knotted1 types to regulate numerous developmental processes. In potato (Solanum tuberosum), the BEL1 transcription factor St BEL5 and its protein partner POTH1 regulate tuber formation by mediating hormone levels in the stolon tip. The accumulation of St BEL5 RNA increases in response to short-day photoperiods, inductive for tuber formation. RNA detection methods and heterografting experiments demonstrate that BEL5 transcripts are present in phloem cells and move across a graft union to localize in stolon tips, the site of tuber induction. This movement of RNA to stolon tips is correlated with enhanced tuber production. Overexpression of BEL5 transcripts that include the untranslated sequences of the BEL5 transcript endows transgenic lines with the capacity to overcome the inhibitory effects of long days on tuber formation. Addition of the untranslated regions leads to preferential accumulation of the BEL5 RNA in stolon tips under short-day conditions. Using a leaf-specific promoter, the movement of BEL5 RNA to stolon tips was facilitated by a short-day photoperiod, and this movement was correlated with enhanced tuber production. These results implicate the transcripts of St BEL5 in a long-distance signaling pathway that are delivered to the target organ via the phloem stream.
Arora, Shafali,Sharma, Shivali,Mithu, Venus S.,Hee-Lee, Chang,Singh, Kamaljit The Royal Society of Chemistry 2015 Chemical communications Vol.51 No.20
<P>Direct disubstitution at the methylene bridges of p-tert-butylcalix[6] arenemethyl ether has been achieved for the first time using a lithiation-substitution protocol. Two stable conformers have been isolated using column chromatography, and their structures have been unambiguously confirmed from 1D, 2D and variable temperature NMR studies and single crystal X-ray structure analysis.</P>
Sara Vergis,Philip Sam,Paul Vergis,Manjit George,Nevil C Philip,Mithu Tomy 대한중환자의학회 2023 Acute and Critical Care Vol.38 No.2
Background Coronavirus disease 2019 (COVID-19) patients with acute respiratory failure who experience delayed initiation of invasive mechanical ventilation have poor outcomes. The lack of objective measures to define the timing of intubation is an area of concern. We investigated the effect of timing of intubation based on respiratory rate-oxygenation (ROX) index on the outcomes of COVID-19 pneumonia. Methods This was a retrospective cross-sectional study performed in a tertiary care teaching hospital in Kerala, India. Patients with COVID-19 pneumonia who were intubated were grouped into early intubation (within 12 hours of ROX index <4.88) or delayed intubation (12 hours or more hours after ROX <4.88). Results A total of 58 patients was included in the study after exclusions. Among them, 20 patients were intubated early, and 38 patients were intubated 12 hours after ROX index <4.88. The mean age of the study population was 57±14 years, and 55.0% of the patients were male; diabetes mellitus (48.3%) and hypertension (50.0%) were the most common comorbidities. The early intubation group had 88.2% successful extubation, while only 11.8% of the delayed group had successful extubation (P<0.001). Survival was also significantly more frequent in the early intubation group. Conclusions Early intubation within 12 hours of ROX index <4.88 was associated with improved extubation and survival in patients with COVID-19 pneumonia.