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Jeun, Minhong,Park, Sungwook,Lee, Hakho,Lee, Kwan Hyi Dove Medical Press 2016 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.11 No.-
<P>Magnetic-based biosensors are attractive for on-site detection of biomarkers due to the low magnetic susceptibility of biological samples. Here, we report a highly sensitive magnetic-based biosensing system that is composed of a miniaturized nuclear magnetic resonance (NMR) device and magnetically engineered nanoferrite particles (NFPs). The sensing performance, also identified as the transverse relaxation (<I>R</I><SUB>2</SUB>) rate, of the NMR device is directly related to the magnetic properties of the NFPs. Therefore, we developed magnetically engineered NFPs (MnMg-NFP) and used them as NMR agents to exhibit a significantly improved <I>R</I><SUB>2</SUB> rate. The magnetization of the MnMg-NFPs was increased by controlling the Mn and Mg cation concentration and distribution during the synthesis process. This modification of the Mn and Mg cation directly contributed to improving the <I>R</I><SUB>2</SUB> rate. The miniaturized NMR system, combined with the magnetically engineered MnMg-NFPs, successfully detected a small amount of infectious influenza A H1N1 nucleoprotein with high sensitivity and stability.</P>
Jeun, Minhong,Park, Sungwook,Jang, Gun Hyuk,Lee, Kwan Hyi American Chemical Society 2014 ACS APPLIED MATERIALS & INTERFACES Vol.6 No.19
<P>A superparamagnetic nanoferrite (SPNF) with high magnetic moment, AC magnetically induced heating (AC-heating) capacity, and good biocompatibility is the most vital part of magnetic fluid hyperthermia for utilizing it in the clinics. Herein, we precisely tune magnetic properties and AC-heating characteristics of Mg<SUB><I>x</I></SUB>Mn<SUB>1–<I>x</I></SUB>Fe<SUB>2</SUB>O<SUB>4</SUB> SPNF via chemically controlling the cations’ concentration and distribution to develop a tailored Mg<SUB><I>x</I></SUB>Mn<SUB>1–<I>x</I></SUB>Fe<SUB>2</SUB>O<SUB>4</SUB> SPNF as a potential magnetic fluid hyperthermia agent. The magnetic and AC-heating characteristics of the tailored Mg<SUB><I>x</I></SUB>Mn<SUB>1–<I>x</I></SUB>Fe<SUB>2</SUB>O<SUB>4</SUB> SPNF are strongly dependent on the Mg/Mn cations’ concentration and distribution, and Mg<SUB>0.285</SUB>Mn<SUB>0.715</SUB>Fe<SUB>2</SUB>O<SUB>4</SUB> SPNF exhibits the highest saturation magnetization and AC-heating capacity as well as high biocompatibility.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/aamick/2014/aamick.2014.6.issue-19/am5057163/production/images/medium/am-2014-057163_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/am5057163'>ACS Electronic Supporting Info</A></P>
Evaluation of Magnetic and Thermal Properties of Ferrite Nanoparticles for Biomedical Applications
Asahi Tomitaka,Minhong Jeun,Seongtae Bae,Yasushi Takemura 한국자기학회 2011 Journal of Magnetics Vol.16 No.2
Magnetic nanoparticles can potentially be used in drug delivery systems and for hyperthermia therapy. The applicability of Fe₃O₄, CoFe₂O₄, MgFe₂O₄, and NiFe₂O₄ nanoparticles for the same was studied by evaluating their magnetization, thermal efficiency, and biocompatibility. Fe₃O₄ and CoFe₂O₄ nanoparticles exhibited large magnetization. Fe₃O₄ and NiFe₂O₄ nanoparticles exhibited large induction heating. MgFe₂O₄ nanoparticles exhibited low magnetization compared to the other nanoparticles. NiFe₂O₄ nanoparticles were found to be cytotoxic, whereas the other nanoparticles were not cytotoxic. This study indicates that Fe₃O₄ nanoparticles could be the most suitable ones for hyperthermia therapy.
Diagnosis of prostate cancer via nanotechnological approach
Kang, Benedict J,Jeun, Minhong,Jang, Gun Hyuk,Song, Sang Hoon,Jeong, In Gab,Kim, Choung-Soo,Searson, Peter C,Lee, Kwan Hyi Dove Medical Press 2015 INTERNATIONAL JOURNAL OF NANOMEDICINE Vol.10 No.-
<P>Prostate cancer is one of the leading causes of cancer-related deaths among the Caucasian adult males in Europe and the USA. Currently available diagnostic strategies for patients with prostate cancer are invasive and unpleasant and have poor accuracy. Many patients have been overly or underly treated resulting in a controversy regarding the reliability of current conventional diagnostic approaches. This review discusses the state-of-the-art research in the development of novel noninvasive prostate cancer diagnostics using nanotechnology coupled with suggested diagnostic strategies for their clinical implication.</P>
Son, Hyun Woo,Jeun, Minhong,Choi, Jaewon,Lee, Kwan Hyi Dove Medical Press 2017 International journal of nanomedicine Vol.12 No.-
<P>An ion-sensitive field-effect transistor (ISFET) biosensor is thought to be the center of the next era of health diagnosis. However, questions are raised about its functions and reliability in liquid samples. Consequently, real-life clinical applications are few in number. In this study, we report a strategy to minimize the sensing signal drift error during bioanalyte detection in an ISFET biosensor. A nanoscale SnO<SUB>2</SUB> thin film is used as a gate oxide layer (GOL), and the surface of the GOL is chemically modified for improving bioanalyte-specific binding and for reducing undesirable ion reactions in sample solutions. The ISFET biosensor with surface-modified GOL shows significantly reduced sensing signal error compared with an ISFET with bare GOL in both diluted and undiluted phosphate buffered saline solutions.</P>