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RISS 인기검색어
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- 저자 : Minhao Zhu (검색결과 4 건)
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Prognostic Value of the Evolution of HER2-Low Expression after Neoadjuvant Chemotherapy
Youzhao Ma,Mingda Zhu,Jingyang Zhang,Minhao Lv,Xiuchun Chen,Zhenzhen Liu 대한암학회 2023 Cancer Research and Treatment Vol.55 No.4
Purpose Patients with human epidermal growth factor receptor 2 (HER2)–low advanced breast cancer can benefit from trastuzumab deruxtecan. Given the unclear prognostic characteristics of HER2-low breast cancer, we investigated the prognostic characteristics of HER2-low expression from primary tumor to residual disease after neoadjuvant chemotherapy (NACT). Materials and Methods The data of HER2-negative patients receiving NACT at our center were collected. Pathological complete response (pCR) rate were compared between HER2-0 and HER2-low patients. The evolution of HER2 expression from primary tumor to residual disease and its impact on disease-free survival (DFS) were examined. Results Of the 690 patients, 494 patients had HER2-low status, of which 72.3% were hormone receptor (HR)–positive (p < 0.001). The pCR rates of HER2-low and HER2-0 patients (14.2% vs. 23.0%) showed no difference in multivariate analysis regardless of HR status. No association was observed between DFS and HER2 status. Of the 564 non-pCR patients, 57 (10.1%) changed to HER2-positive, and 64 of the 150 patients (42.7%) with HER2-0 tumors changed to HER2-low. HER2-low (p=0.004) and HR-positive (p=0.010) tumors before NACT were prone to HER2 gain. HER2 gain patients had a better DFS compared with HER2-negative maintained patients (87.9% vs. 79.5%, p=0.048), and the DFS of targeted therapy group was better than that of no targeted therapy group (92.4% vs. 66.7%, p=0.016). Conclusion Although HER2-low did not affect the pCR rate and DFS, significant evolution of HER2-low expression after NACT creates opportunities for targeted therapy including trastuzumab.
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Well-dispersed graphene toward robust lubrication via reorganization of sliding interface
Zhuang Zhao,Xiaoqiang Fan,Yuting Li,Zihan Zeng,Xiaofeng Wei,Kaiyue Lin,Minhao Zhu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
Excellent lubrication performance of graphene lubricant is mostly attributed to the dispersion of graphene and forming of tribo-film. Herein, diethylene glycol dodecyl ether (E2C12) functionalized graphene oxide (E2C12-GO) was successfully prepared by simple esterification. The physicochemical properties of as-prepared samples were characterized by a series of characterization methods. E2C12-GO with flat edge and high-level spacing possesses high dispersion stability in PAO 20 base oil. Compared with base oil, 0.08 wt% E2C12-GO could achieve the reduction of average friction coefficient and wear rate by 30 % and 57 % at 150 N, respectively. Even with each long-term friction, E2C12-GO could still maintain the state of robust low friction coefficient. Meanwhile, the addition of E2C12-GO can significantly improve the loadbearing capacity (PB value and PD value) of base oil. The excellent tribological properties of E2C12-GO were attributed to high dispersion and high layer spacing, as well as the reorganization of sliding interface. Prospectively, the E2C12-GO shows promising potential as a multi-functional oil-based lubricating additive in industrial applications.
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Bonded flake MoS2 solid lubricant coating: An effective protection against fretting wear
Jianing Yin,Han Yan,Meng Cai,Shijie Song,Xiaoqiang Fan,Minhao Zhu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-
The multiple advantages of flake MoS2 are of great significance for improving the fretting wear resistanceof bonded solid lubricant coating. Herein, the coating was constructed with liquid-phase exfoliated flakeMoS2 as lubricating filler and epoxy resin as binder. The tangential fretting characteristics for the contactof AISI 52,100 steel ball against the as-prepared coating on the AISI 1045 steel were investigated underthree displacement amplitude. Results show that the average friction coefficient and wear rate of thecoating with flake MoS2 maximumly reduce by 45.5% and 89.8% than those with bulk MoS2. Moreover,the fretting regime is regulated by the coatings with different composition and performance. Such excellentanti-fretting features depend on: (a) the intrinsic shearing properties of flake MoS2; (b) the repairingeffect on the worn area; (c) the formation of uniform transfer film.
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