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First Report of Green Mold Disease Caused by Trichoderma hengshanicum on Ganoderma lingzhi
( Mingzhu Cai ),( Muhmmad Idrees ),( Yi Zhou ),( Chunlan Zhang ),( Jize Xu ) 한국균학회 2020 Mycobiology Vol.48 No.5
Ganoderma lingzhi is a well-known source of natural fungal medicines which has been given for the treatment of several diseases. China is one of the major commercial producers of Ganoderma mushroom worldwide. However, with the expansion of the commercial cultivation, the occurrence of the fungal diseases on G. lingzhi has also been increased. The green mold disease symptoms were observed in the cultivation base of G. lingzhi in Zuojia Town, Jilin City, Jilin Province, China, causing the basidiomes to be rotten and withered, and the green mycelium layer generated gradually. The pathogenicity tests showed the same symptoms as appeared naturally in Zuojia mushroom base. Morphology characters revealed conidia green, ellipsoid, globose, 2.56-4.83×2.09-4.22 μm, length-width ratio was 1.1-1.2 (n=10). Conidiophores trichoderma-like, often asymmetry, branches solitary, paired or in whorls of 3 phialides formed solitary, paired or in whorl, variable in shape, lageniform, sometimes ampulliform or subulate. While using molecular methodology, comparing with the sequences of Trichoderma hengshanicum from GenBank, the analyzed sequence showed 97.32% homology with the RPB2 sequences, 100% with the TEF1-α sequences. A fungus isolated from the diseased tissues was identified based on morphology and molecular studies as T. hengshanicum. This is the first report of T. hengshanicum causing the green mold disease of G. lingzhi in China.
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Lingyu Wang,Yu Miao,Mingzhu Xu,Xiumin Gao 한국광학회 2023 Current Optics and Photonics Vol.7 No.2
Radially polarized beams with the ability to generate a sub-wavelength sized spot in a longitudinal field provides significant applications in microscopic imaging, optical tweezers, lithography and so on. However, this excellent property can also be achieved based on conventional circularly polarized beams. Here, we demonstrate its ability to create a strong longitudinal field by comparing the tight focusing characteristics of fractional-order vortex modulated radial polarized and left-handed circular polarized Bessel-Gauss beams. Additionally, the possibility of generating arbitrary fractional-order vortex modulated Bessel-Gauss beams with a strong longitudinal field is demonstrated. A special modulation method of left-handed circularly polarized Bessel-Gauss beams modulated by a fractional-order vortex is adopted creatively and a series of regulation laws are obtained. Specifically, the fractional-order phase modulation parameter n can accurately control the number of optical lobes. The ratio of the pupil radius to the incident beam waist β 1 can control the radius of the optical lobes. The first-order Bessel function amplitude modulation parameter β 2 can control the number of layers of optical lobes. This work not only adds a new modulation method for optical micromanipulation and optical communication, but also enriches the research on fractional vortex beams which has very important academic significance.
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Yu Deng,Wanjun Guo,Guancheng Li,Shuang Li,Hong Li,Xinyan Li,Bei Niu,Mingzhu Song,Yamei Zhang,Zhijian Xu,Fulun Li 한국유방암학회 2020 Journal of breast cancer Vol.23 No.1
Purpose: C-terminal binding protein 1 (CtBP1) is a transcriptional co-repressor that is overexpressed in many cancers. CtBP1 transcriptionally represses a broad array of tumor suppressors, which promotes cancer cell proliferation, migration, invasion, and resistance to apoptosis. Recent studies have demonstrated that CtBP1 is a potential target for cancer therapy. This study was designed to screen for compounds that potentially target CtBP1. Methods: Using a structure-based virtual screening for CtBP1 inhibitors, we found protocatechuic aldehyde (PA), a natural compound found in the root of a traditional Chinese herb, Salvia miltiorrhiza, that directly binds to CtBP1. Microscale thermophoresis assay was performed to determine whether PA and CtBP1 directly bind to each other. Further, clustered regularly interspaced short palindromic repeats associated Cas9 nuclease-mediated CtBP1 knockout in breast cancer cells was used to validate the CtBP1 targeting specificity of PA. Results: Functional studies showed that PA repressed the proliferation and migration of breast cancer cells. Furthermore, PA elevated the expression of the downstream targets of CtBP1, p21 and E-cadherin, and decreased CtBP1 binding affinity for the promoter regions of p21 and E-cadherin in breast cancer cells. However, PA did not affect the expression of p21 and E-cadherin in the CtBP1 knockout breast cancer cells. In addition, the CtBP1 knockout breast cancer cells showed resistance to PA-induced repression of proliferation and migration. Conclusion: Our findings demonstrated that PA directly bound to CtBP1 and inhibited the growth and migration of breast cancer cells through CtBP1 inhibition. Structural modifications of PA are further required to enhance its binding affinity and selectivity for CtBP1.
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