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Structure and morphological characteristics of polygonal salt crust, the West Juyan Lake, China
Guoming Zhang,Yuting Xiao,Mingzhu Xiang,Chang Hong,Bo-Tao Zhang,Lianyou Liu,Peijun Shi,Jifu Liu 한국지질과학협의회 2022 Geosciences Journal Vol.26 No.3
Polygonal salt crust patches (PSCPs) in modern playas have critical hydrologic implications for arid areas, but the morphology and origin of these polygonal features are under debate. This study investigated the structure and morphological characteristics of crustal landforms in a modern playa located in the West Juyan Lake, western Inner Mongolia of China, through an integrated analysis of high-resolution remote sensing images obtained from Google Earth, pedestrian field surveys, and unmanned aerial vehicle photography. The study area covers approximately 2,650 ha and the number of salt crust patches was 3,491. Across this area, the coverage and number of salt crust patches varied with elevation and sedimentary environment. The results show that the polygonal patch pattern of the salt crust landforms was fractal, and similar polygonal patch perimeter to area ratios and landscape index values prevail in the study area. The wind erosion of material on the surface of the Gobi Desert, a mountain torrent alluvial fan, and material carried by seasonal river water probably provided the provenance of the regional salt crust landforms. The structure and morphological characteristics of salt crust in typical playas of the arid and semiarid region are important for better understanding their composition and sedimentary environment. This study can help reveal relevant information regarding environmental change and provide a reference for saline dust emissions from playas in arid areas.
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BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression
Zeng Furong,Li Yayun,Meng Yu,Sun Huiyan,Yi He,Yin Mingzhu,Chen Xiang,Deng Guangtong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Targeting bromodomain and extra-terminal domain (BET) proteins has shown a promising therapeutic effect on melanoma. The development of strategies to better kill melanoma cells with BET inhibitor treatment may provide new clinical applications. Here, we used a drug synergy screening approach to combine JQ1 with 240 antitumor drugs from the Food and Drug Administration (FDA)-approved drug library and found that sunitinib synergizes with BET inhibitors in melanoma cells. We further demonstrated that BET inhibitors synergize with sunitinib in melanoma by inducing apoptosis and cell cycle arrest. Mechanistically, BET inhibitors sensitize melanoma cells to sunitinib by inhibiting GDF15 expression. Strikingly, GDF15 is transcriptionally regulated directly by BRD4 or indirectly by the BRD4/IL6/STAT3 axis. Xenograft assays revealed that the combination of BET inhibitors with sunitinib causes melanoma suppression in vivo. Altogether, these findings suggest that BET inhibitor-mediated GDF15 inhibition plays a critical role in enhancing sunitinib sensitivity in melanoma, indicating that BET inhibitors synergize with sunitinib in melanoma.
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