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Xiangyu Hou,Xupeng Bai,Xiaoli Gou,Hang Zeng,Chen Xia,Wei Zhuang,Xinmeng Chen,Zhongxiang Zhao,Min Huang,Jing Jin 한국분자세포생물학회 2015 Molecules and cells Vol.38 No.5
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important redox-sensitive transcription factor that regulates the expression of several cytoprotective genes. More recently, genetic analyses of human tumors have indicated that Nrf2 may cause resistance to chemotherapy. In this study, we found that the expression levels of Nrf2 and its target genes GCLC, HO-1, NQO1 were significantly higher in cisplatinresistant A549 (A549/CDDP) cells than those in A549 cells, and this resistance was partially reversed by Nrf2 siRNA. 3',4',5',5,7-Pentamethoxyflavone (PMF), a natural flavonoid extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.
Hou, Xiangyu,Bai, Xupeng,Gou, Xiaoli,Zeng, Hang,Xia, Chen,Zhuang, Wei,Chen, Xinmeng,Zhao, Zhongxiang,Huang, Min,Jin, Jing Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.5
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an important redox-sensitive transcription factor that regulates the expression of several cytoprotective genes. More recently, genetic analyses of human tumors have indicated that Nrf2 may cause resistance to chemotherapy. In this study, we found that the expression levels of Nrf2 and its target genes GCLC, HO-1, NQO1 were significantly higher in cisplatin-resistant A549 (A549/CDDP) cells than those in A549 cells, and this resistance was partially reversed by Nrf2 siRNA. 3,4,5,5,7-Pentamethoxyflavone (PMF), a natural flavon extracted from Rutaceae plants, sensitized A549/CDDP to CDDP and substantially induced apoptosis compared with that of CDDP alone treated group, and this reversal effect decreased when Nrf2 was downregulated by siRNA. Mechanistically, PMF reduced Nrf2 expression leading to a reduction of Nrf2 downstream genes, and in contrast, this effect was decreased by blocking Nrf2 with siRNA. Taken together, these results demonstrated that PMF could be used as an effective adjuvant sensitizer to increase the efficacy of chemotherapeutic drugs by downregulating Nrf2 signaling pathway.
이산화탄소 지중저장 부지 선정을 위한 해저면 탄성파 탐사자료의 영상화: 포항 영일만 해저면 탐사자료의 2차원 역시간 구조보정
박세은 ( Sea-eun Park ),이향월 ( Xiangyue Li ),김병엽 ( Byoung Yeop Kim ),오주원 ( Ju-won Oh ),민동주 ( Dong-joo Min ),김형수 ( Hyoung-soo Kim ) 한국지구물리·물리탐사학회 2021 지구물리와 물리탐사 Vol.24 No.3
Owing to the abnormal weather conditions due to global warming, carbon capture and storage (CCS) technology has attracted global attention as a countermeasure to reduce CO<sub>2</sub> emissions. In the Pohang CCS demonstration project in South Korea, 100 tons of CO<sub>2</sub> were successfully injected into the subsurface CO<sub>2</sub> storage in early 2017. However, after the 2017 Pohang earthquake, the Pohang CCS demonstration project was suspended due to an increase in social concerns about the safety of the CCS project. In this study, to reconfirm the structural suitability of the CO<sub>2</sub> storage site in the Pohang Basin, we employed seismic imaging based on reverse-time migration (RTM) to analyze small-scale ocean-bottom seismic data, which have not been utilized in previous studies. Compared with seismic images using marine streamer data, the continuity of subsurface layers in the RTM image using the ocean-bottom seismic data is improved. Based on the obtained subsurface image, we discuss the structural suitability of the Pohang CO<sub>2</sub> storage site.