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Design an Implementation of an Ontology-based Knowldge Management System
Hideki Mima,Taesung Yoon,Katsumori Matsushima 한국전자거래학회 2004 한국전자거래학회 학술대회 발표집 Vol.2004 No.-
The purpose of the study is to develop an integrated knowledge management system for the domains of genome and nano-technology, in which terminology-based literature mining, knowledge acquisition, knowledge structuring, and knowledge retrieval are combined. The system supports integrating different types of databases (papers and patents, technologies and innovations) and retrieving different types of knowledge simultaneously. The main objective of the system is to facilitate knowledge acquisition from documents and new knowledge discovery through a terminology-based similarity calculation and a visualization of automatically structured knowledge. Implementation issue of the system is also mentioned.
Hamada, Tsuyoshi,Liu, Li,Nowak, Jonathan A.,Mima, Kosuke,Cao, Yin,Ng, Kimmie,Twombly, Tyler S.,Song, Mingyang,Jung, Seungyoun,Dou, Ruoxu,Masugi, Yohei,Kosumi, Keisuke,Shi, Yan,da Silva, Annacarolina,G Elsevier 2018 European journal of cancer Vol.103 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>High-level plasma 25-hydroxyvitamin D [25(OH)D] has been associated with lower colorectal cancer incidence and mortality. Considering evidence indicating immunomodulatory effects of vitamin D, we hypothesised that survival benefits from high systemic vitamin D level might be stronger for colorectal carcinoma with lower immune response to tumour.</P> <P><B>Methods</B></P> <P>Using 869 colon and rectal cancer cases within the Nurses' Health Study and Health Professionals Follow-up Study, we assessed the prognostic association of postdiagnosis 25(OH)D score [derived from diet and lifestyle variables to predict plasma 25(OH)D level] in strata of levels of histopathologic lymphocytic reaction. The Cox proportional hazards regression model was adjusted for potential confounders, including microsatellite instability, CpG island methylator phenotype, LINE-1 methylation, <I>PTGS2</I> (cyclooxygenase-2) expression and <I>KRAS</I>, <I>BRAF</I> and <I>PIK3CA</I> mutations.</P> <P><B>Results</B></P> <P>The association of postdiagnosis 25(OH)D score with colorectal cancer-specific mortality differed by levels of peritumoural lymphocytic reaction (<I>p</I> <SUB>interaction</SUB> = 0.001). Multivariable-adjusted mortality hazard ratios for a quintile-unit increase of 25(OH)D score were 0.69 [95% confidence interval (CI), 0.54–0.89] in cases with negative/low peritumoural lymphocytic reaction, 1.08 (95% CI, 0.93–1.26) in cases with intermediate peritumoural reaction and 1.25 (95% CI, 0.75–2.09) in cases with high peritumoural reaction. The survival association of the 25(OH)D score did not significantly differ by Crohn's-like lymphoid reaction, intratumoural periglandular reaction or tumour-infiltrating lymphocytes.</P> <P><B>Conclusions</B></P> <P>The association between the 25(OH)D score and colorectal cancer survival is stronger for carcinomas with lower peritumoural lymphocytic reaction. Our results suggesting interactive effects of vitamin D and immune response may contribute to personalised dietary and lifestyle intervention strategies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The survival association of vitamin D is stronger in cancer with fewer lymphocytes. </LI> <LI> Vitamin D and peritumoural lymphocytes interact to modify cancer progression. </LI> <LI> Vitamin D may exert anti-tumour immune-enhancing effects. </LI> <LI> Peritumoural lymphocytic reaction may be a biomarker for benefits from vitamin D. </LI> <LI> Our data support immunomodulatory lifestyle interventions for cancer patients. </LI> </UL> </P>
Vorticity dynamics, drift wave turbulence, and zonal flows: a look back and a look ahead
Diamond, P H,Hasegawa, A,Mima, K Published jointly by The Institute of Physics and 2011 Plasma physics and controlled fusion Vol.53 No.12
<P>This paper surveys the basic ideas and results on fundamental models of drift wave turbulence, the formation of zonal flows, shear suppression of turbulence and transport, coupled drift wave and zonal flow dynamics and application to transport bifurcations and transitions. Application to vortex dynamics and zonal flow phenomena in EMHD systems are discussed, as well. These are relevant to aspects of ICF and laser plasma physics. Throughout, an effort is made to focus on fundamental physics ideas.</P>