Evaluation of the Radiation Pneumonia Development Risk in Lung Cancer Cases

Yilmaz, Sercan,Adas, Yasemin Guzle,Hicsonmez, Ayse,Andrieu, Meltem Nalca,Akyurek, Serap,Gokce, Saban Cakir Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Background: Concurrent chemo-radiotherapy is the recommended standard treatment modality for patients with locally advanced lung cancer. The purpose of three-dimensional conformal radiotherapy (3DCRT) is to minimize normal tissue damage while a high dose can be delivered to the tumor. The most common dose limiting side effect of thoracic RT is radiation pneumonia (RP). In this study we evaluated the relationship between dose-volume histogram parameters and radiation pneumonitis. This study targeted prediction of the possible development of RP and evaluation of the relationship between dose-volume histogram (DVH) parameters and RP in patients undergoing 3DCRT. Materials and Methods: DVHs of 41 lung cancer patients treated with 3DCRT were evaluated with respect to the development of grade ${\geq}2$ RP by excluding gross tumor volume (GTV) and planned target volume (PTV) from total (TL) and ipsilateral (IPSI) lung volume. Results: Were admitted statistically significant for p<0.05. Conclusions: The cut-off values for V5, V13, V20, V30, V45 and the mean dose of TL-GTV; and V13, V20,V30 and the mean dose of TL-PTV were statistically significant for the development of Grade ${\geq}2$ RP. No statistically significant results related to the development of Grade ${\geq}2$ RP were observed for the ipsilateral lung and the evaluation of PTV volume. A controlled and careful evaluation of the dose-volume histograms is important to assess Grade ${\geq}2$ RP development of the lung cancer patients treated with concurrent chemo-radiotherapy. In the light of the obtained data it can be said that RP development may be avoided by the proper analysis of the dose volume histograms and the application of optimal treatment plans.

Optimization of Equal Channel Angular Pressing Parameters for Improving the Hardness and Microstructure Properties of Al–Zn–Mg Alloy by Using Taguchi Method

Guzide Meltem Lule Senoz,Taha Alper Yilmaz 대한금속·재료학회 2021 METALS AND MATERIALS International Vol.27 No.3

In this study, optimization of equal channel angular pressing (ECAP) parameters was aimed to improve the mechanical andmicrostructure properties of Al–Zn–Mg alloy using the Taguchi method with ANOVA analysis. Three different parameters(process temperature, processing route, and the number of passes) with three different levels were examined so L9(33)orthogonal array was employed. The effects of these parameters on the microstructure properties of Al–Zn–Mg alloy werestudied using X-ray diffractometer, optical microscopy, scanning electron microscopy, electron backscatter diffraction andtransmission electron microscopy and mechanical properties were measured by Vickers micro-hardness experimental tests. Among the samples obtained, the sample that meets the desired hardness and grain size value was characterized. The resultsindicate that eight pass ECAP in route Bcat 100 °C is found as a more appropriate condition that meets the highest microhardnessvalue and the lowest grain size value. Microstructural investigations showed that grain size was highly affectedby the temperature, and is less affected by the number of passes and ECAP routes. The results showed that the increasingECAP temperature leads to a decrease in the fraction of HABs, an increase in the grain size and an increase in the equiaxedof the grains.

Azo Dye Removal Using Free and Immobilized Fungal Biomasses: Isotherms, Kinetics and Thermodynamic Studies

Gulay Bayramoglu,Meltem Yilmaz 한국섬유공학회 2018 Fibers and polymers Vol.19 No.4

In this study, Lentinus concinnus biomass was immobilized in polyvinyl alcohol/polyethyleneoxide hydrogels (PVA/PEO; referred as composite biomass) and used for removal of Reactive Yellow 86 dye (RY-86) from aqueous solution using free fungal biomass as a control system. The free fungal and composite fungal biomasses were characterized using ATR-FTIR, SEM and analytical methods. FTIR studies of the adsorbent preparations show that carboxylate, hydroxyl and amine groups should be involved in adsorption of the RY-86 dye. The adsorption of RY-86 dye on these adsorbents increased as the initial concentration of RY-86 dye in the medium increased up to 200 mg/l. The maximum RY-86 dye adsorption for the free fungal and composite fungal biomasses, was obtained as 190.2 and 87.6, respectively, using 200 mg/l initial dye concentration, at 25 oC, and at pH 5.0 with 2.0 h contact. The equilibrium data were well described with the Freundlich and Temkin isotherm models. The adsorption of RY-86 dye was fitted best by the pseudo second-order kinetic model. Thermodynamic parameters (ΔGo, ΔHo, and ΔSo) showed that RY-86 dye adsorption on both adsorbents were spontaneous process.

Comparison of 2-Dimensional and 3-Dimensional Conformal Treatment Plans in Gastric Cancer Radiotherapy

Adas, Yasemin Guzle,Andrieu, Meltem Nalca,Hicsonmez, Ayse,Atakul, Tugba,Dirican, Bahar,Aktas, Caner,Yilmaz, Sercan,Akyurek, Serap,Gokce, Saban Cakir,Ergocen, Salih Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Background: Postoperative chemoradiotherapy is accepted as standard treatment for stage IB-IV, M0 gastric cancer. Radiotherapy (RT) planning of gastric cancer is important because of the low radiation tolerance of surrounding critical organs. The purpose of this study was to compare the dosimetric aspects of 2-dimensional (2D) and 3-dimensional (3D) treatment plans, with the twin aims of evaluating the adequacy of 2D planning fields on coverage of planning target volume (PTV) and 3D conformal plans for both covering PTV and reducing the normal tissue doses. Materials and Methods: Thirty-six patients with stage II-IV gastric adenocarcinoma were treated with adjuvant chemoradiotherapy using 3DRT. For each patient, a second 2D treatment plan was generated. The two techniques were compared for target volume coverage and dose to normal tissues using dose volume histogram (DVH) analysis. Results: 3DRT provides more adequate coverage of the target volume. Comparative DVHs for the left kidney and spinal cord demonstrate lower radiation doses with the 3D technique. Conclusions: 3DRT produced better dose distributions and reduced radiation doses to left kidney and spinal cord compared to the 2D technique. For this reason it can be predicted that 3DRT will result in better tumor control and less normal tissue complications.

Impact of increased aspartate aminotransferase to alanine aminotransferase (De Ritis) ratio in prognosis of testicular cancer

Sacit Nuri Gorgel,Yigit Akin,Esra Meltem Koc,Osman Kose,Serkan Ozcan,Yuksel Yilmaz 대한비뇨의학회 2019 Investigative and Clinical Urology Vol.60 No.3

Purpose: Imaging studies can show metastasis in testicular cancer (TCa); however, a test for risk of metastasis in TCa has not been described. The ratio of aspartate aminotransferase to alanine aminotransferase, also called the De Ritis ratio (DRR), is used for many other malignancies. We aimed to evaluate the association between preoperatively assessed DRR and prognosis in patients with TCa. Materials and Methods: One hundred twenty-eight patients with TCa were enrolled in a retrospective study between March 2007 and January 2017. Clinical, biochemical, and pathological data were recorded. Univariate and multivariate logistic regression analyses were used. The prognostic value of DRR and the threshold value were assessed by use of receiver operating characteristic curves. Significance was defined as p<0.05. Results: Mean follow-up was 37±9.7 months. There were 45 and 73 TCa patients with and without lymph node metastasis, respectively. Lung metastases and other solid organ metastases occurred in 14 and 4 patients, respectively. The optimal DRR threshold was 1.30 for both retroperitoneal lymph node involvement and metastasis. DRR was determined as an independent prognostic factor for retroperitoneal lymph node involvement and organ metastasis in univariate and multivariate analyses (p<0.001, p=0.006 and p=0.002, p=0.047, respectively). Conclusions: A preoperative DRR greater than 1.30 may be an independent risk factor for retroperitoneal lymph node involvement and organ metastases in patients with TCa.

Elevated Serum Neutrophil to Lymphocyte and Platelet to Lymphocyte Ratios Could be Useful in Lung Cancer Diagnosis

Kemal, Yasemin,Yucel, Idris,Ekiz, Kubilay,Demirag, Guzin,Yilmaz, Bahiddin,Teker, Fatih,Ozdemir, Meltem Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Background: Lung cancer (LC) is still the primary cause of cancer deaths worldwide, and late diagnosis is a major obstacle to improving lung cancer outcomes. Recently, elevated preoperative or pretreatment neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) and mean platelet volume (MPV) detected in peripheral blood were identified as independent prognostic factors associated with poor survival with various cancers, including colon cancer, esophageal cancer, gastric cancer and breast cancer. Objective: The aim of this study was to examine whether MPV, NLR and PLR could be useful inflammatory markers to differentiate lung cancer patients from healthy controls. An investigation was also made of the relationship between these markers and other prognostic factors and histopathological subgroups. Materials and Methods: Retrospectively eighty-one lung cancer patients and 81 age-sexes matched healthy subjects included into the study. Patients with hypertension, hematological and renal disease, heart failure, chronic infection, hepatic disorder and other cancer were excluded from the study. The preoperative or pretreatment blood count data was obtained from the recorded computerized database. Results: NLR and PLR values were significantly higher in the LC patients compared to the healthy subjects.( NLR: 4.42 vs 2.45 p=0.001, PLR: 245.1 vs 148.2 p=0.002) MPV values were similar in both groups (7.7 vs 7.8). No statistically significant relationship was determined between these markers (MPV, NLR and PLR) and histopathological subgroups and TNM stages. Conclusions: NLR and PLR can be useful biomarkers in LC patients before treatment. Larger prospective studies are required to confirm these findings.