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Hepatoprotective Effects of Potato Peptide against D-Galactosamineinduced Liver Injury in Rats
Kiyoshi Ohba,Kyu-Ho Han,Ruvini Liyanage,Megumi Nirei,Naoto Hashimoto,Ken-ichiro Shimada,Mitsuo Sekikawa,Keiko Sasaki,Chi-Ho Lee,Michihiro Fukushima 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.6
The effect of some peptides on hepatoprotection and cecal fermentation against D-galactosamine (GalN)-treated rats was studied. In acute hepatic injury tests, serum alanine aminotransferase (ALT), aspartate aminotranferase (AST), and lactic dehydrogenase (LDH) activities were remarkably increased after injection of GalN. However, potato and soybean peptides significantly decreased GalN-induced alterations of serum ALT and AST activities. Hepatic thiobarbituric acidreactive substance (TBARS) concentration in GalN-treated groups fed potato and soybean peptides was significantly lower than that in GalN-treated control group. Hepatic glutathione level in the GalN-treated group fed potato peptide was significantly higher than that in GalN-treated control group. Furthermore, cecal Lactobacillus level in GalN-treated groups fed potato and soybean peptides was significantly higher than that in GalN-treated control group, and cecal short-chain fatty acid concentrations in GalN-treated group fed potato peptide were significantly higher than in GalN-treated control group. These results indicate that potato peptide may improve the cecal fermentation and prevent the GalN-induced liver damage in rats.
Influences of Allocating HIV/AIDS Specialized Nurses on Clinical Outcomes in Japan
Masakazu Nishigaki,Yuko Sugino,Jongmi Seo,Megumi Shimada,Kazuko Ikeda,Keiko Kazuma 한국간호과학회 2011 Asian Nursing Research Vol.5 No.1
Purpose This retrospective cohort study was conducted to demonstrate how allocation of nurses specialized in HIV care influences clinical outcomes of antiretroviral therapy (ART) for people living with HIV (PLWH). Methods The medical records of 116 PLWH who started ART between January 2002 and December 2004 were analyzed. Occurrence of viral suppression and viral relapse after suppression achievement and their time from baseline were observed as clinical outcomes related to ART. Clinical outcomes were obtained from medical records between January 2002 and December 2006. PLWH were classified into two groups according to allocation (n = 95, nurse allocated group) or nonallocation (n = 21, nurse nonallocated group) of nurses specialized in HIV. Results Survival analysis showed that HIV viral load was suppressed more rapidly and continuously in nurse allocated group than nonallocated group (p < .0001). Viral relapse after suppression achievement occurred easily in nurse nonallocated group than allocated group (p = .003). Conclusions The present findings demonstrated that the role of specialized nurses is critically important from the viewpoint of clinical outcome. [Asian Nursing Research 2011;5(1):11–18]
Yoshihide Kanno,Tetsuya Ohira,Yoshihiro Harada,Yoshiki Koike,Taku Yamagata,Megumi Tanaka,Tomohiro Shimada,Kei Ito 대한소화기내시경학회 2018 Clinical Endoscopy Vol.51 No.3
Afferent loop syndrome is often difficult to resolve. Among patients with afferent loop syndrome whose data were extracted fromdatabases, 5 patients in whom metal stent placement was attempted were included and evaluated in this study. The procedure wastechnically successful without any adverse events in all patients. Metal stent(s) was placed with an endoscope in the through-the-scopemanner in 4 patients and via a percutaneous route in 1 patient. Obvious clinical efficacy was observed in all patients. Adverse eventsrelated to the procedure and stent occlusion during the follow-up period were not observed. Metal stent placement for malignantobstruction of the afferent loop was found to be safe and feasible.