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        Physical Frailty and Sarcopenia: Development of a Framework for Supporting Interventions Against Incident Mobility Disability

        Matteo Cesari 대한노인병학회 2017 Annals of geriatric medicine and research Vol.21 No.2

        In 2014, the Innovative Medicines Initiative funded a 48-million Euros project entitled “Sarcopenia and Physical fRailty IN older people: multi-componenT Treatment strategies”(SPRINTT). The SPRINTT consortium federates partners from academia, industry, and the private sector to address an important gap in the geriatric field: the lack of a standardized and clinically relevant definition of sarcopenia. In particular, the SPRINTT project aims to involve all major stakeholders in the framing of a skeletal muscle-specific risk profile that exposes the individual at risk of negative health-related outcomes(in particular, disability), is amenable to benefiting from preventive interventions, and meets the standards requested by regulatory agencies. During the first year of activity, the SPRINTT consortium has implemented a “Physical Frailty & Sarcopenia”(PF&S) condition that considers existing evidence and regularly exchanges information with the European Medicines Agency. This condition is currently the study objective of a 3-year randomized controlled trial in multiple countries across Europe. The trial aims to verify whether a multicomponent intervention (based on physical activity and nutritional counseling) can prevent the onset of mobility disabilities in community-dwelling older persons with PF&S. The present article provides an overview of the SPRINTT background and rationale and explains the details of the PF&S condition.

      • KCI등재

        Challenges and Opportunities for Academic Journals to Serve the Older Population in Western Pacific Region

        Hee-Won Jung,Wee Shiong Lim,Matteo Cesari,Tung Wai Auyeung,Taro Kojima,Ga Hyuk,Ian D. Cameron,임재영 대한노인병학회 2021 Annals of geriatric medicine and research Vol.25 No.4

        Annals of Geriatric Medicine and Research held its inaugural international editorial board virtual meeting on September 16, 2021, to brainstorm ideas for sustainable growth. This special article summarizes the key concepts obtained from the webinar proceedings, with further development of ideas from ensuing discussions occurring after the meeting. From the initial discussion points provided by eight editorial board members, including six presenters, email discussions further enriched these ideas to construct the current special article. The key points discussed were: impactful research and impact factors, international and Asian perspectives, and challenges to sustainable growth. The editors noted the existing gap between the impact factor and research impact as a challenge for the growth paths of regional journals. However, they agreed that persevering with impactful research would ultimately translate into parallel and gradual gains in impact, which is, therefore, consistent with the organic growth of the journal. Acknowledging challenges in navigating between unique Asian perspectives and international outlooks, the editors encouraged academic journals to serve as bridges linking international evidence with the richness of local perspectives. For sustainable growth, the editors suggested that journals may be forged into the academic ecosystems of the region, diversify value streams, and establish themselves as reputable brands in disciplines. By combining these discussions, we proposed the “IMPACT” strategy for journals on the growth path in the region, which stands for IMmersive user experience encompassing authors, reviewers, and readers; Pasteur’s quadrant use-inspired research; Asia-Pacific context; Collaborative; and Translation to practice and policy.

      • KCI등재

        Bounce Forward Better: Geriatric and Gerontological Research in the Post-pandemic Future

        Jee Hyun Noh,Hidenori Arai,Tung Wai Auyeung,Matteo Cesari,Walter R. Frontera,Hyuk Ga,Hee-Won Jung,Wee Shiong Lim,Jae Young Lim 대한노인병학회 2022 Annals of geriatric medicine and research Vol.26 No.4

        In recent years, we have faced challenges in managing coronavirus disease 2019 (COVID-19), especially in older adults. The pandemic has precipitated a global health crisis that impeded older adults from maintaining their health. Disruption of the routine management of chronic diseases, physical inactivity deteriorating physical function and quality of life, malnutrition, and mental disorders have been suggested as major threats to the health of older adults. To address these problems and facilitate reactivation of normal care activities, this article summarizes the contents of a webinar held by the Annals of Geriatric Medicine and Research (AGMR) regarding the future directions of geriatric medicine and research in the post-COVID-19 era.

      • KCI등재

        A Case of Reversible Dementia? Dementia vs Delirium in Lyme Disease

        Chiara Sanchini,Chiara Papia,Chiara Cutaia,Tino Emanuele Poloni,Matteo Cesari 대한노인병학회 2023 Annals of geriatric medicine and research Vol.27 No.1

        Lyme disease is an uncommon cause of reversible dementia. A 75-year-old male patient, with a personal history of mild memory deficit, was admitted to Alzheimer’s Disease Care Unit due to hallucinations, confusion and aggressive behavior unresponsive to antipsychotic therapy. A computed tomography (CT) scan of the brain was negative, while blood exams showed a rise in inflammatory parameters. A complete screening of infective diseases showed a positive serology for Borrelia burgdorferi, confirmed at Western blot. Even though the patient refused cerebrospinal fluid (CSF) exam, the brilliant clinical improvement after the appropriate antimicrobial therapy is strongly suggestive for a diagnosis of neuroborreliosis. This case report underlines the importance of a diagnostic approach to dementia, as to find out and treat the reversible causes.

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