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- 저자 : Masuda-Ozawa, Tokiha (검색결과 4 건)
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Masuda-Ozawa, Tokiha,Hoang, Trish,Seo, Yeon-Soo,Chen, Lin-Feng,Spies, Maria Oxford University Press 2013 Nucleic acids research Vol.41 No.6
<P>DNA repair helicases function in the cell to separate DNA duplexes or remodel nucleoprotein complexes. These functions are influenced by sensing and signaling; the cellular pool of a DNA helicase may contain subpopulations of enzymes carrying different post-translational modifications and performing distinct biochemical functions. Here, we report a novel experimental strategy, single-molecule sorting, which overcomes difficulties associated with comprehensive analysis of heterologously modified pool of proteins. This methodology was applied to visualize human DNA helicase F-box–containing DNA helicase (FBH1) acting on the DNA structures resembling a stalled or collapsed replication fork and its interactions with RAD51 nucleoprotein filament. Individual helicase molecules isolated from human cells with their native post-translational modifications were analyzed using total internal reflection fluorescence microscopy. Separation of the activity trajectories originated from ubiquitylated and non-ubiquitylated FBH1 molecules revealed that ubiquitylation affects FBH1 interaction with the RAD51 nucleoprotein filament, but not its translocase and helicase activities.</P>
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Manish Mishra,Shogo Ozawa,Tatsuhiko Masuda,Fumi Yoshioka,Yoshinobu Tanaka 대한치과보철학회 2011 The Journal of Advanced Prosthodontics Vol.3 No.3
PURPOSE Finite element study on the effect of abutment length and material on implant bone interface against dynamic loading. MATERIALS AND METHODS Two dimensional finite element models of cylinderical implant, abutments and bone made by titanium or polyoxymethylene were simulated with the aid of Marc/Mentat software. Each model represented bone, implant and titanium or polyoxymethylene abutment. Model 1: Implant with 3 mm titanium abutment, Model 2: Implant with 2 mm polyoxymethylene resilient material abutment, Model 3: Implant with 3 mm polyoxymethylene resilient material abutment and Model 4: Implant with 4 mm polyoxymethylene resilient material abutment. A vertical load of 11 N was applied with a frequency of 2 cycles/sec. The stress distribution pattern and displacement at the junction of cortical bone and implant was recorded. RESULTS When Model 2, 3 and 4 are compared with Model 1, they showed narrowing of stress distribution pattern in the cortical bone as the height of the polyoxymethylene resilient material abutment increases. Model 2, 3 and 4 showed slightly less but similar displacement when compared to Model 1. CONCLUSION Within the limitation of this study, we conclude that introduction of different height resilient material abutment with different heights i.e. 2 mm, 3 mm and 4 mm polyoxymethylene, does not bring about significant change in stress distribution pattern and displacement as compared to 3 mm Ti abutment. Clinically, with the application of resilient material abutment there is no significant change in stress distribution around implant-bone interface.
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Structural Design of High-Rise Building in Toranomon-Azabudai Project (A Block)
Kazumasa, Okabe,Kai, Toyama,Takuya, Furuta,Jyunichi, Yamashita,Hiroki, Mukai,Takahiro, Goseki,Shingo, Masuda,Dai, Shimazaki,Yusuke, Miyagi,Yuji, Ozawa Council on Tall Building and Urban Habitat Korea 2022 International journal of high-rise buildings Vol.11 No.3
This paper explains about structural planning and structural design of the high-rise building in Toranomon-Azabudai Project (A Block) which is now under construction. The building is about 330 meters high, has 4.2 aspect ratio, and the outline of the building has shallow curve. We adopted seismic response control structure. The building is a steel rigid frame structure with braces, and it has enough stiffness to obtain its primary natural period to be less than about seven seconds, in consideration of wind response, seismic response and inhabitability for the wind shaking. In terms of business continuity plan, the building has a high seismic performance; value of story drift angle shall be 1/150 or less and members of the building remain almost undamaged while or after a large earthquake. Active mass dumper shall be installed at the top of the building to improve inhabitability while strong wind is blowing.
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Steric Effect on the Nucleophilic Reactivity of Nickel(III) Peroxo Complexes
Kim, Jalee,Shin, Bongki,Kim, Hyunjeong,Lee, Junhyung,Kang, Joongoo,Yanagisawa, Sachiko,Ogura, Takashi,Masuda, Hideki,Ozawa, Tomohiro,Cho, Jaeheung American Chemical Society 2015 Inorganic Chemistry Vol.54 No.13
<P>A set of nickel(III) peroxo complexes bearing tetraazamacrocyclic ligands, [Ni<SUP>III</SUP>(TBDAP)(O<SUB>2</SUB>)]<SUP>+</SUP> (TBDAP = <I>N</I>,<I>N</I>′-di-<I>tert</I>-butyl-2,11-diaza[3.3](2,6)pyridinophane) and [Ni<SUP>III</SUP>(CHDAP)(O<SUB>2</SUB>)]<SUP>+</SUP> (CHDAP = <I>N</I>,<I>N</I>′-dicyclohexyl-2,11-diaza[3.3](2,6)pyridinophane), were prepared by reacting [Ni<SUP>II</SUP>(TBDAP)(NO<SUB>3</SUB>)(H<SUB>2</SUB>O)]<SUP>+</SUP> and [Ni<SUP>II</SUP>(CHDAP)(NO<SUB>3</SUB>)]<SUP>+</SUP>, respectively, with H<SUB>2</SUB>O<SUB>2</SUB> in the presence of triethylamine. The mononuclear nickel(III) peroxo complexes were fully characterized by various physicochemical methods, such as UV–vis, electrospray ionization mass spectrometry, resonance Raman, electron paramagnetic resonance, and X-ray analysis. The spectroscopic and structural characterization clearly shows that the NiO<SUB>2</SUB> cores are almost identical where the peroxo ligand is bound in a side-on fashion. However, the different steric properties of the supporting ligands were confirmed by X-ray crystallography, where the CHDAP ligand gives enough space around the Ni core compared to the TBDAP ligand. The nickel(III) peroxo complexes showed reactivity in the oxidation of aldehydes. In the aldehyde deformylation reaction, the nucleophilic reactivity of the nickel(III) peroxo complexes was highly dependent on the steric properties of the macrocyclic ligands, with a reactivity order of [Ni<SUP>III</SUP>(TBDAP)(O<SUB>2</SUB>)]<SUP>+</SUP> < [Ni<SUP>III</SUP>(CHDAP)(O<SUB>2</SUB>)]<SUP>+</SUP>. This result provides fundamental insight into the mechanism of the structure (steric)–reactivity relationship of metal peroxo intermediates.</P><P>A set of nickel(III) peroxo complexes, [Ni<SUP>III</SUP>(TBDAP)(O<SUB>2</SUB>)]<SUP>+</SUP> and [Ni<SUP>III</SUP>(CHDAP)(O<SUB>2</SUB>)]<SUP>+</SUP>, were prepared. The spectroscopic characterization clearly shows that the NiO<SUB>2</SUB> cores are almost identical. However, the different steric properties of the supporting ligands were confirmed by structural characterization. The nucleophilic reactivity of the nickel(III) peroxo complexes was highly dependent on the steric properties of the macrocyclic ligands, with a reactivity order of [Ni<SUP>III</SUP>(TBDAP)(O<SUB>2</SUB>)]<SUP>+</SUP> < [Ni<SUP>III</SUP>(CHDAP)(O<SUB>2</SUB>)]<SUP>+</SUP>.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/inocaj/2015/inocaj.2015.54.issue-13/acs.inorgchem.5b00294/production/images/medium/ic-2015-002943_0012.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ic5b00294'>ACS Electronic Supporting Info</A></P>
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