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Masroor, Imrana,Zeeshan, Sana,Afzal, Shaista,Sufian, Saira Naz,Ali, Madeeha,Khan, Shaista,Ahmad, Khabir Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.18
Background: To determine the outcome and cost saving by placing ultrasound guided surgical clips for tumor localization in patients undergoing neo-adjuvant chemotherapy for breast cancer. Materials and Methods: This retrospective cross sectional analytical study was conducted at the Department of Diagnostic Radiology, Aga Khan University Hospital, Karachi, Pakistan from January to December 2014. A sample of 25 women fulfilling our selection criteria was taken. All patients came to our department for ultrasound guided core biopsy of suspicious breast lesions and clip placement in the index lesion prior to neo-adjuvant chemotherapy. All the selected patients had biopsy proven breast cancer. Results: The mean age was $45{\pm}11.6years$. There were no complications seen after clip placement in terms of clip migration or hemorrhage. The cost of commercially available markers was approximately PKR 9,000 (US$ 90) and that of the surgical clip was PKR 900 (US$ 9). The cost of surgical clips in 25 patients was PKR 22,500 (US$ 225), when compared to the commercially available markers which may have incurred a cost of PKR 225,000 (US$ 2,250). The total cost saving for 25 patients was PKR 202,500 (US$ 2, 025), making it PKR 8100 (US$ 81) per patient. Conclusions: The results of our study show that ultrasound guided surgical clip placement in index lesions prior to neo-adjuvant therapy is a safe and cost effective method to identify tumor bed and response to treatment for further management.
Masroor, Mirza,Mir, Rashid,Javid, Jamsheed,Prasant, Y,Imtiyaz, A,Mariyam, Z,Mohan, Anant,Ray, PC,Saxena, Alpana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Background: NSCLC is a disease involving uncontrolled cell growth, which could result in metastases into nearby tissues beyond the lungs. Materials and Methods: The aim of the present study was to analyze the influence of epidermal growth factor receptor (EGFR) gene expression on metastasis and survival in NSCLC patients. The present case-control study included 100 cases of NSCLC patients and 100 age and sex matched controls. EGFR gene expression was analyzed by quantitative real time PCR using serum RNA. Association with NSCLC patient survival was analyzed by the Kaplan-Meier method. Results: We analyzed EGFR gene expression and observed mean increased gene expression of 13.5 fold in NSCLC patients. Values reflected overall survival of patients with a median of 15.8 months in the cases of <13 fold increased gene expression vs 6.7 months with >13 fold increased EGFR gene expression (p=0.005). Distant metastatic patients with <13 fold increased EGFR gene expression had 7.9 months of median survival time while>13 fold increased EGFR gene expression had only 5 months of median survival time (p=0.03). Non metastatic patients with <13 fold increased EGFR gene expression had 18 months of median survival time as compared to only 7.1 months with >13 fold increased expression. Conclusions: Higher cell free EGFR mRNA expression may play an important role in causing distant metastases and reducing overall survival of NSCLC patients in the Indian population.
Masroor, Mirza,Amit, Jain,Javid, Jamsheed,Mir, Rashid,Prasant, Y,Imtiyaz, A,Mariyam, Z,Mohan, Anant,Ray, PC,Saxena, Alpana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Background: The epidermal growth factor (EGF) plays important roles in non-small cell lung cancer (NSCLC) susceptibility and functional polymorphism in the EGF (+61A/G) gene has been linked to increased risk of NSCLC. This study aimed to evaluate the role of the EGF +61A/G polymorphism in risk of NSCLC adenocarcinoma (ADC) occurrence and survival in an Indian population. Materials and Methods: This casecontrol study included 100 histopathologically confirmed NSCLC (ADC) patients and 100 healthy controls. EGF (A61G) was genotyped by AS-PCR to elucidate putative associations with clinical outcomes. The association of the polymorphism with the survival of NSCLC patients was estimated by Kaplan-Meier curves. Results: It was found that EGF 61AG heterozygous and GG homozygous genotype is significantly associated with increased risk of NSCLC (ADC) occurrence compared to AA genotype, [OR 2.61 (1.31-5.18) and 3.25 (1.31-8.06), RR 1.51(1.15-2.0) and 1.72 (1.08-2.73) and RD 23.2 (6.90-39.5) and 28.53(7.0-50.1) for heterozygous AG (p=0.005) and homozygous GG (p=0.009)]. Patients homozygous for the G allele exhibited a significantly poor overall survival. The median survival time for patients with EGF 61 AA, AG, and GG genotypes was 10.5, 7.4, and 7.1 months (p=0.02), respectively. NSCLC (ADC) patients with GG + AG exhibited 7.3 months median survival compared to the AA genotype (p=0.009). Conclusions: The present study revealed that the EGF A61G genotype may be a novel independent prognostic marker to identify patients at higher risk of occurrence and an unfavourable clinical outcome.
Clinical Significance of the NQO1 C609T Polymorphism in Non Small Cell Lung Adenocarcinoma Patients
Masroor, Mirza,Jain, Amit,Javid, Jamsheed,Mir, Rashid,Prashant, Y,Imtiyaz, A,Mariyam, Z,Mohan, Anant,Ray, PC,Saxena, Alpana Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.17
Background: NAD(P)H:quinone oxidoreductase 1 (NQO1) is part of the antioxidant defence system involved in detoxification. This study aimed to analyze the influence of NQO1 (C609T) genetic polymorphism in non small cell lung cancer (NSCLC)as a putative risk factor. Materials and Methods: Present study included 100 cases of NSCLC (adenocarcinoma) patients and 100 age and sex matched healthy controls. NQO1 (C609T) genotyping was performed by allele specific PCR for assessment of putative associations with clinical outcome and genotypes of. The association of the polymorphism with the survival of NSCLC patients' was analyzed by Kaplan-Meier method. Results: In Indian NSCLC (adenocarcinoma) patients increased risk of developing NSCLC was found to be associated with NQO1 609TT genotype [OR 3.68(0.90-14.98), RR 2.04(0.78-5.31)] for CT [OR 2.91(1.58-5.34), RR 1.74(1.23-2.44) p=0.0005 for CT], for CT+TT [ OR 3.26(1.82-5.82), RR 1.87(1.34-2.61) p<0.0001 for CT+TT]. A significant difference (p=0.0009) was observed in genotype distribution among cases and healthy controls. Patients with CT+TT genotype exhibited a significant poor overall survival compared with patients displaying homozygous CC genotype (p=0.03) and when survival independently compared with CC, TT and CT genotype was also found to be significantly associated (p=0.02). Overall median survival times were CT 6.0 months, TT 8.2 months, and CT + TT (6.4 months)]. Conclusions: The present study revealed that NQO1 CT, TT and CT+TT genotypes may be associated with clinical outcome and risk of developing NSCLC in the Indian population.
Leader following Speed Consensus in Induction Motors using Multi-Agent and Hybrid Controller Scheme
Suhaib Masroor,Chen Peng,Ayesha Rafique,Zain Anwar Ali,Muhammad Aamir 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.12
This paper explores a novel design of utilizing Leader following multi-agent system (MAS) consensus algorithm with Field Oriented Control (FOC), induction motors using a Hybrid control scheme containing regulation, pole placement and tracking (here after RST), controller along with model reference adaptive control (MRAC). To ensure system stability, Massachusetts institute of technology (MIT), rule is incorporated to validate that the cost function gets diminished over time. To follow the speed of leader, a leader following consensus protocol of multi-agent system is merged so that we can control the speed of induction motors. In this new approach, each motor along with its complete unit (Voltage Source Converter (VSC) and local controller) is considered as a single agent. It is proved that the consensus is reached among leader and its followers not only without delay but also with delay. The communication topology is supposed to be fixed and it is also assumed that every agent can share its information (speed data), with neighbors. The model is simulated using MATLAB and obtained results ensure the effectiveness of the design approach.
BLDC Multi-Motor Speed Synchronization by Leader Following Multi-Agent and Hybrid Control
Suhaib Masroor,Chen Peng,Muhammad Aamir,Zain Anwar Ali 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.12
In this article, a unique and innovative design for addressing the speed synchronization problem in a multi-motor system using Brush less DC (BLDC), motors is presented by utilizing motor back emf equation and rotor position commonly called sensor less technique. In the proposed method, the system is modelled as a consensus problem of leader following multi-agent system (MAS), and a hybrid controller is designed by using Model Reference Adaptive Control (MRAC) along with Variable Structure (VS) control technique of Sliding Mode Control (SMC), herein called Variable Structure Model Reference Adaptive Control (VS-MRAC). The consensus algorithm of MAS (reformed w.r.t motor speed data), is fused with the hybrid controller to reach consensus on speed regulated by proposed hybrid controller. The stability of a system is endorse by designing a Lyapunov function. The efficiency of the proposed methodology is proven by simulations performed in MATLAB and the acquired results validate the success of proposed design methodology.
Muhammad Maqsood,Rahmatullah Qureshi,Masroor Ikram,M. Sheeraz Ahmad,Bushra Jabeen,Muhammad Rafique Asi,Junaid Ahmed Khan,Safdar Ali,Lothar Lilge 한국한의학연구원 2018 Integrative Medicine Research Vol.7 No.2
Background: The Pakistani Salt Range has a rich floral diversity including Withania coagulans from the Solanaceae family. Methods: The crude methanolic extracts of the root, leaf, leaf stalk, and fruit of this plant were screened for their cytotoxic activity against human (HeLa, MCF-7, RD) and rat (RG2 and INS-1) cancer cell lines at 20 μg/mL and compared to methotrexate. The IC50 values indicated that leaf stalk and fruit extracts exert an 80% or higher cytotoxic activity against all cell lines at 24 hours. Results: The leaf stalk extract showed the highest cytotoxic efficacy against all tested cell lines, with IC50 values ranging from 0.96 ± 0.01 μg/mL to 4.73 ± 0.05 μg/mL followed by the fruit extract with IC50 values of 0.69 ± 0.01–6.69 ± 0.06 μg/mL after 48–72 hours incubation. The leaf stalk and seed extracts were analyzed for polyphenols and flavonoids using RP-HPLC. The total flavonoid content (TFC) was calculated for all tested samples, and the highest TFC was recorded for the root extract (394.34 ± 1.26 μg/g). The total phenolic content (TPC) was found in the seed extract (307.86 ± 9.42 μg/g) of W. coagulans. The highest contents of myricetin (358.46 ± 2.91 μg/g) were noted in the leaf extract, and highest quercetin was recorded in the seed extract (21.43 ± 0.13 μg/g). The highest gallic acid concentration (83.62 ± 0.71 μg/g) was recorded in leaf stalk extract and p-hydroxybenzoic acid in the seed extract (157.46 ± 1.43 μg/g). Conclusion: The present study gives a scientific insight and comparative analysis of various plant parts in this medicinally important plant species from the Salt Range of Pakistan against both human and rat cancer cells.
Impact of Lockdown on Air Pollutants during COVID-19 at Patna, India
Mohammed Aasif Sulaiman,Mohammad Masroor Zafar,Nishat Afshan,Anupma Kumari 한국대기환경학회 2021 Asian Journal of Atmospheric Environment (AJAE) Vol.15 No.4
Many countries shut their borders, imposed nationwide lockdown, and restricted several anthropogenic activities to arrest the spread of COVID-19. In the present study, the concentration of several air pollutants (PM10, PM2.5, NO2, NH3, SO2, CO and O3) during different phases of lockdown from monitoring stations of Patna was analyzed to assess the effect of lockdown restriction on air quality. Reduction in PM2.5, NH3, NO2, PM10 and CO concentration was observed by 59.79%, 58.2%, 49.49%, 39.57% and 24.04%, respectively during the lockdown period. National Air Quality Index (NAQI) value in the year 2020 had been observed to lower by 57.88% compared to the year 2019, during the same period. A more significant fall in the concentration of air pollutants was observed during the early phase of post-lockdown compared to the late stages of postlockdown. The study reflects the significance of restriction on anthropogenic activities in improving air quality and provides clues for future action plans for improving air quality.