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Masayuki Sekine,Takayuki Enomoto,Masami Arai,Hiroki Den,Hiroyuki Nomura,Takeshi Ikeuchi,Seigo Nakamura 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.4
Objective: and mutation carriers are recommended to undergo risk-reducing salpingo-oophorectomy (RRSO) by age 40 and 45, respectively. However, the carriers have a different way of thinking about their life plan. We aimed to investigate the distribution of age at diagnosis of ovarian cancer (OC) patients to examine the optimal timing of RRSO in the carriers. Methods: We examined a correlation between age at diagnosis of OC and common mutation types in 3,517 probands that received genetic testing. Among them, germline mutation (g m), germline mutation (g m) and germline wild-type (g wt) were found in 185, 42 and 241 OC patients, respectively. Results: The average age at diagnosis of OC in g m and g m was 51.3 and 58.3 years, respectively, and the difference from g wt (53.8 years) was significant. Theg m carriers did not develop OC under the age of 40. The average age was 50.1 years for L63X and 52.8 years for Q934X in , and 55.1 years for R2318X and 61.1 years for STOP1861 in . The age at diagnosis in L63X or R2318X carriers was relatively younger than other or carriers, however their differences were not significant. With L63X and R2318X carriers, 89.4% (42/47) and 100% (7/7) of women were able to prevent the development of OC, respectively, when RRSO was performed at age 40. Conclusion: There appears to be no difference in the age at diagnosis of OC depending on the type of common mutation. Further analysis would be needed.
PROMOTING START UP OF UASB REACTORS BY ADDING OF WATER ABSORBING POLYMER
今井岡,FUKAGAWA, Masayuki,LIU, Jun,UKITA, Masao,SEKINE, Masahiko,NAKANISHI, Hiroshi 嶺南大學校 環境問題硏究所 1997 環境硏究 Vol.17 No.1
ABSTRACTWe have developed a new approach to enhance granulation by adding water absorbing polymer (WAP) particles into the inoculated digested sludge. In this study, the effect of adding WAP on formation of anaerobic granular sludge was evaluated in lab-scale UASB reactors using two typical synthetic wastewater, i.e. glucose of volatile fatty acid (VFA) mixture solution. In addition, side by side with the lab-scale experiment, a pilot-scale experiment using the VFA mixture was carried out to evaluate the availability of accelerated start-up by adding WAP. The development of granular sludge was significantly enhanced by adding WAP. Granules developed on glucose and VFAs had high methanogenic activities and good settleability. From results of lab-scale experiment, the recommended dosage of WAP was about 750 mg/l of reactor volume. The results, pilot-scale experiment, indicated the availability of accelerated start-up adding WAP.