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        Preoperative predictive factors of pancreatic fistula after pancreaticoduodenectomy: usefulness of the CONUT score

        Masashi Utsumi,Hideki Aoki,Seiichi Nagahisa,Seitaro Nishimura,Yuta Une,Yuji Kimura,Megumi Watanabe,Fumitaka Taniguchi,Takashi Arata,Koh Katsuda,Kohji Tanakaya 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.99 No.1

        Purpose: Postoperative pancreatic fistula (POPF) is the most important factor affecting morbidity and mortality after pancreaticoduodenectomy (PD). Patients with a high controlling nutritional status (CONUT) score, which is used to assess nutritional status, are expected to have high morbidity rates. This study aimed to determine the usefulness of the CONUT score. Methods: Data from 97 consecutive cases of PD performed in the Department of Surgery of Iwakuni Clinical Center, from April 2008 to May 2018, were included. Preoperative patient data, including sex, age, and hypertension, and postoperative complication data were collected to analyze pancreatic fistula occurrence. Results: Of the 97 patients, 2 9 patients (29.8%) were diagnosed with POPF ≥ B, with 26 cases (26.8%) classified as grade B and 3 (3.1%) as grade C. The mortality rate was 2.1% (2 of 97). In the univariate analysis, a significant association was observed between POPF and the following factors: body mass index (BMI) ≥ 22 kg/m2, high CONUT score, nonpancreatic carcinoma, and CT attenuation values. In multivariate analysis, BMI ≥ 22 kg/m2 (odds ratio [OR], 6.16; P < 0.001), high CONUT score (OR, 3.77; P = 0.009), nonpancreatic carcinoma (OR, 5.72; P = 0.009), and CT attenuation values (late/early ratio) in the pancreas (OR, 9.07; P = 0.006) were independent risk factors for POPF. Conclusion: Patients with a high CONUT score are at high risk of POPF. Further study correlating preoperative nutritional intervention with risk of POPF is necessary

      • KCI등재

        Preoperative lymphocyte-to-C-reactive protein ratio predicts hepatocellular carcinoma recurrence after surgery

        Masashi Utsumi,Masaru Inagaki,Koji Kitada,Naoyuki Tokunaga,Midori Kondo,Yuya Sakurai,Kosuke Yunoki,Ryosuke Hamano,Hideaki Miyasou,Yousuke Tsunemitsu,Shinya Otsuka 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.103 No.2

        Purpose: This study was performed to determine the prognostic value of lymphocyte-to-CRP ratio after curative resection for hepatocellular carcinoma. Methods: Between July 2010 and October 2021, 173 consecutive patients (144 male, 29 female) who underwent surgical resection for pathologically confirmed hepatocellular carcinoma were included in this retrospective study. Cox regression analysis was used to evaluate the relationship between clinicopathological characteristics and recurrence-free survival (RFS) and overall survival (OS). A P-value of <0.05 was considered statistically significant. Results: The patients (mean age, 71 years) were stratified into high (≥9,500, n = 108) and low (<9,500, n = 65) lymphocyte- to-CRP ratio groups. The low lymphocyte-to-CRP ratio group had significantly worse RFS and OS. Low lymphocyte-to- CRP ratio (hazard ratio [HR], 1.865; 95% confidence interval [CI], 1.176–2.960; P = 0.008), multiple tumors (HR, 3.333; 95% CI, 2.042–5.343; P < 0.001), and microvascular invasion (HR, 1.934; 95% CI, 1.178–3.184; P = 0.009) were independently associated with RFS, whereas low albumin-to-globulin ratio (HR, 2.270; 95% CI, 1.074–4.868; P = 0.032), α-FP of ≥25 ng/mL (HR, 2.187; 95% CI, 1.115–4.259; P = 0.023), and poor tumor differentiation (HR, 2.781; 95% CI, 1.041–6.692; P = 0.042) were independently associated with OS. Lymphocyte-to-CRP ratio had a higher area under the curve (0.635) than other inflammation-based markers (0.51–0.63). Conclusion: Lymphocyte-to-CRP ratio is superior to other inflammation-based markers as a predictor of RFS in patients with surgically resected hepatocellular carcinoma.

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        Surface Hardening of Titanium Using Gas Nitriding

        Masashi Yoshida,Ryuta Ichiki,Noah Utsumi 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.

        In this study, a rotary barrel tank was employed with gas nitriding in an attempt to form a hard layer on the surface of pure titanium. Nitriding was carried out at 773 K to 1073 K for 3.6 ks to 32.4 ks. Alumina powders were used as the media that flowed in the barrel tank. A new surface hardening process was developed for forming hard layers on a pure titanium surface. A uniform hard layer could be formed on pure titanium surfaces using barrel nitriding. With barrel nitriding, the treatment time did not have an effect on the surface hardness, but had a strong effect on the depth of the hard layer. Moreover, nitrogen was able to diffuse into titanium surface,and TiN and Ti2N could be formed on the surface using this process.

      • KCI등재

        Suppressing Method of the Cross Section Deformation for Extruded Square Tubes in Press Bending

        Kunito Nakajima,Noah Utsumi,Masashi Yoshida 한국정밀공학회 2013 International Journal of Precision Engineering and Vol. No.

        Aluminum alloys are widely used in the automotive industry to realize weight reductions. Extruded square tubes made from aluminum alloys show superior workability, and therefore, they are used as lightweight structural elements in various fields. To use such tubes in automobile parts, fabrication processes such as bending are necessary. However, bending can easily cause undesirable distortions such as thickness deviation and flattening. Generally, the use of a mandrel is considered to suppress these distortions effectively. However, studies have not yet established a bending technology for achieving highly accurate cross sections. This study aims to develop a press bending technology for obtaining tubes with highly accurate cross sections. First, we designed and developed a restraint jig for use in this bending process. A laminated mandrel was applied to the inside of the square tube and a constraint load was applied to the restraint plate on the outside to suppress cross-sectional deformation. The effect of the use of a mandrel and restraint plate on the bending of a square tube was experimentally investigated. Furthermore, the press bending process was analyzed through simulations using the finite element method (FEM).

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