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RISS 인기검색어
- 검색키워드
- 저자 : Masaki Kurata (검색결과 4 건)
- 무료
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Masaki Kurata 한국원자력학회 2016 Nuclear Engineering and Technology Vol.48 No.1
Research and development (R&D) methodology for the practical use of accident tolerant fuel(ATF) in commercial light water reactors is discussed in the present review. The identificationand quantification of the R&D-metrics and the attribute of candidate ATF-concepts,recognition of the gap between the present R&D status and the targeted practical use, prioritizationof the R&D, and technology screening schemes are important for achieving acommon understanding on technology screening process among stakeholders in the nearterm and in developing an efficient R&D track toward practical use. Technology readinesslevels and attribute guides are considered to be proper indices for these evaluations. In themidterm, the selected ATF-concepts will be developed toward the technology readinesslevel-5, at which stage the performance of the prototype fuel rods and the practicality ofindustrial scale fuel manufacturing will be verified and validated. Regarding the screenedoutconcepts, which are recognized to have attractive potentials, the fundamental R&Dshould be continued in the midterm to find ways of addressing showstoppers.
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Kurata, Masaki Korean Nuclear Society 2016 Nuclear Engineering and Technology Vol.48 No.1
Research and development (R&D) methodology for the practical use of accident tolerant fuel (ATF) in commercial light water reactors is discussed in the present review. The identification and quantification of the R&D-metrics and the attribute of candidate ATF-concepts, recognition of the gap between the present R&D status and the targeted practical use, prioritization of the R&D, and technology screening schemes are important for achieving a common understanding on technology screening process among stakeholders in the near term and in developing an efficient R&D track toward practical use. Technology readiness levels and attribute guides are considered to be proper indices for these evaluations. In the midterm, the selected ATF-concepts will be developed toward the technology readiness level-5, at which stage the performance of the prototype fuel rods and the practicality of industrial scale fuel manufacturing will be verified and validated. Regarding the screened-out concepts, which are recognized to have attractive potentials, the fundamental R&D should be continued in the midterm to find ways of addressing showstoppers.
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MAXIZYMEs: Allosterically controllable ribozymes with biosensor functions
Kurata, Hiroyuki,Miyagishi, Makoto,Kuwabara, Tomoko,Warashina, Masaki,Taira, Kazunari Korean Society for Biochemistry and Molecular Biol 2000 Journal of biochemistry and molecular biology Vol.33 No.5
Ribozymes are catalytic RNAs that can cleave RNAs at specific sites, thus they have been employed to degrade a target mRNA in vivo. Development of allosterically controllable ribozymes is of great current interest, but it remained difficult to furnish such functions to ribozymes in cultured cells or in animals. Recently, we designed allosterically controllable ribozymes termed maxizymes, which have sensor arms that recognize target mRNA sequences and, in the presence of such target sequences only, they form a cavity that can capture catalytically indispensable $Mg^{2+}$ ions, cleaving the target. The maxizyme was applied to therapy for chronic myelogenous leukemia (CML). It cleaved specifically the chimeric BCR-ABL mRNA, which caused CML, without damaging the normal ABL or BCR mRNA in mammalian cells and also in mice, providing the first successful example for allosteric control of the activity of artificial ribozymes in vivo.
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Review / MAXIZYMEs : Allosterically controllable ribozymes with biosensor functions
(Hiroyuki Kurata),(Makoto Miyagishi),(Tomoko Kuwabara),(Masaki Warashina),(Kazunari Taira) 생화학분자생물학회 2000 BMB Reports Vol.33 No.5
Ribozymes are catalytic RNAs that can cleave RNAs at specific sites, thus they have been employed to degrade a target mRNA in vivo. Development of allosterically controllable ribozymes is of great current interest, but it remained difficult to furnish such functions to ribozymes in cultured cells or in animals. Recently, we designed allosterically controllable ribozymes termed maxizymes, which have sensor arms that recognize target mRNA sequences and, in the presence of such target sequences only, they form a cavity that can capture catalytically indispensable Mg^(2+) ions, cleaving the target. The maxizyme was applied to therapy for chronic myelogenous leukemia (CML). It cleaved specifically the chimeric BCR-ABL mRNA, which caused CML, without damaging the normal ABL or BCR mRNA in mammalian cells and also in mice, providing the first successful example for allosteric control of the activity of artificial ribozymes in vivo.
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