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RISS 인기검색어
- 검색키워드
- 저자 : Maria Papaioannou (검색결과 2 건)
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Fotios Dimitriadis,Maria Papaioannou,Ioannis Sokolakis,Aikaterini Fragou,Dimitrios Hatzichristou,Apostolos Apostolidis 대한배뇨장애요실금학회 2021 International Neurourology Journal Vol.25 No.1
Purpose: Preclinical data increasingly support an impact of low-intensity extracorporeal shockwave therapy (Li-ESWT) on the bladder. We investigated the molecular effects of Li-ESWT on the bladder of a streptozotocin-induced diabetic rat model. Methods: Fifteen 8-week-old male Wistar rats were randomized into 3 groups: a control group (n=5), a group of diabetic rats without treatment (diabetes mellitus [DM], n=5) and a group of diabetic rats treated with Li-ESWT (DM-ESWT, n=5). A single intraperitoneal dose of streptozotocin (60 mg/kg) was used to induce diabetes. Twenty days after diabetes induction, each rat in the DM-ESWT group received 300 shockwaves with an energy flux density of 0.09 mJ/mm2. Sessions were repeated 3 times/week for 2 weeks, followed by a 2-week washout period. Total RNA from bladder tissue was extracted, cDNA was synthesized, and quantitative real-time polymerase chain reaction was performed to analyze the expression pattern of transient receptor potential vanilloid 1 (Trpv1), interleukin-1β (Il1b), and the muscarinic receptors M1, M2, and M3 (Chrm1, Chrm2, and Chrm3). Results: The expression of Trpv1, Il1b, and Chrm2 genes was significantly different between the 3 groups (P=0.002, P<0.0001, and P=0.011, respectively; 1-way analysis of variance). In the DM group, the expression of all genes was higher than in the control group, but statistical significance was observed only for Trpv1 and Il1b (P=0.002 and P<0.0001, respectively). Li-ESWT significantly reduced the expression of Il1b and Chrm2 (P=0.001 and P=0.011, respectively), whereas a nonsignificant tendency for reduced expression was noted for Trpv1 (P=0.069). Conclusions: The induction of diabetes was associated with increased expression of genes related to mechanosensation, inflammation/ ischemia, and contraction in the rat bladder. Li-ESWT reduced the expression of IL1b, Chrm2, and to a lesser extent Trpv1 toward the control levels, suggesting the therapeutic potential of this treatment modality for diabetic cystopathy.
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Comparison of three skin-stretching devices for closing skin defects on the limbs of dogs
Vassiliki Tsioli,Lysimachos G. Papazoglou,Nikolaos Papaioannou,Dimitra Psalla,Ioannis Savvas,Leonidas Pavlidis,Maria Karayannopoulpou 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.1
Our objective was to evaluate the effectiveness of skin-stretching devices for closing defects on the extremities of dogs. Antebrachial skindefects were created on the limbs of 24 dogs randomly divided into three groups. Skin stretchers included staples and sutures passing throughthem (group A), sutures and hypodermic needles (group B), and Pavletic device (group C). Wounds on the left were further undermined inall groups. Tension and blood perfusion were assessed. After removing the stretchers on day 3, the defects were sutured and wound healingwas clinically scored. Histological variables evaluated were cellular infiltration, edema, collagen orientation, and thickness of epidermis. Significant differences in tension were found among groups (p < 0.0005) and between measurement times for undermined (p = 0.001) ornon-undermined (p < 0.0005) wounds. In contrast, blood perfusion values did not differ significantly. Clinical scores for group B seemedto be better than those for groups A and C, but differences were not significant. Primary wound closure using the Pavletic device was notfeasible. Νo significant differences in histological variables were found between groups. Skin stretching with staples or hypodermic needlesresulted in successful wound management with minor side effects on skin histology and circulation.
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