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( Maximiliano Toscano ),( Maria Lourdes Posadas Martinez ),( Pablo Marcelo Ajler ),( Maria Victoria Franco ),( Maria Teresa Garcia Botta ),( Ezequiel Goldschmidt ),( Fernan Gonzalez Bernaldo De Quiros 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Venous thromboembolism (VTE) includes deep vein thrombosis (DVT) and pulmonary embolism (PE). VTE represents the fi rst cause of preventable morbidity and mortality in neurosurgery, these patients have many additional risk factors for VTE, but thromboprophylaxis is discussed for threatened complications. Estimated annual incidence in the United States is 600, 000 cases, with a mortality of nearly 17% at 3 months after diagnosis. Objetive: To estimate the incidence of postoperative VTE in patients with neurosurgery and to describe thrombophylactic measures, assigned treatment and associated complications. Methods: Retrospective cohort of all patients (=17 years) who underwent a neurosurgical procedure from January 2010 to January 2012. All patients were followed up to 90 days to evaluate the presence of VTE and/or death. Baseline characteristics, thromboprophylaxis, treatment for VTE and complications were evaluated. Results: During two years, 321 patients met the inclusion criteria. VTE incidence was 3. 1% (10 cases, 95% CI:1. 2%-4. 9%), 5 patients developed DVT, the other half developed both DVT and PE. 52% were female, median age was 55 (RIC 35-66) years. From the total of patients, 71% (229) received thromboprophylaxis, from which 58% implemented mechanical thromboprophylaxis and 42% received associated pharmacologic prophylaxis. 4 of the 10 patients with DVT were receiving prophylaxis at the time of the event. Not receiving thromboprophylaxis increased 1. 5 times (95%, CI:0. 95-2. 38, p=0. 001) the risk of presenting VTE that in those who received thromboprophylaxis. The risk of developing PE was 4 times (95%, CI:0. 73-22%, p=0. 001) bigger in those who didn´t receive thromboprophylaxis. 80% of patients received treatment for VTE: anticoagulants (4), thrombolytics and anticoagulants (1), thrombolytics (1), thrombolytics and fi lter (1) and 1 received fi lter and anticoagulation. For complications, no ETV patients died, one required hospitalization and 6. 9% (22) had major bleedings. Conclusions: VTE remains an important complication in neurosurgical patients.
Francisco Claudio Dantas Mota,Duvaldo Eurides,Patricia Maria Coletto Freitas,Marcelo Emilio Beletti,Michelle Rodriques Goulart,Livia Maria Ferreira Cunha,Luiz Antonio Franco da Silva,Maria Clorinda So 대한수의학회 2004 Journal of Veterinary Science Vol.5 No.3
The aim of this study was to evaluate the cicatricial repair of perforating cornea in rabbits, by using the Nbutyl cyanoacrylate adhesive compared to the 910- polyglactine thread suture through macroscopic and histological assays. Corneas from 18 adult rabbits were perforated and subsequently occluded with N-butyl cyanoacrylate synthetic adhesive (right cornea) or by separated single points using the 910-polyglactine thread (left cornea). The rabbits were divided into groups containing three animals per group. Examination after 7, 15, and 30 days post-operative showed that both the synthetic adhesive and the suture were efficient in the occlusion of the surgical wounds, thus stabilizing the intra-ocular content. The N-butyl cyanoacrylate adhesive was shown to be superior to the 910-polyglactine suture thread with regards to the evolution and the organization of the healing process.
Tamires Carvalho dos Santos,George Abreu Filho,Ana Carolina Oliveira,Thiago José Onório Rocha,Fabiano de Paula Pereira Machado,Renata Cristina Ferreira Bonomo,Katia Iro Altides Mota,Marcelo Franco 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.1
This study aimed at demonstrating the effects of fermentation time (24, 48, 72, 96, and 120 h) and water activity (0.943, 0.970, and 0.985) on the production of cellulolytic enzymes by solid-state fermentation of purple mombin (Spondias purpurea L.) residue using Aspergillus niger. The fermentation was carried out at 35oC and the enzyme production was measured as endoglucanase and total cellulose activities. The optimum condition for endoglucanase was water activity 0.974 and 93.8 h of fermentation, reaching a production of 3.21 U/g of residue;whereas for total cellulase it was 0.958 and 79.4 h achieving 12.1 U/g of residue. Fermentation time had a greater effect on the endoglucanase activity, while water activity had a more significant influence on the total cellulase activity. Endoglucanase had optimum activity at temperature of 50oC and pH 5.0. Although cellulase total optimum activity was also at pH 5.0, the maximum activity was at 60oC.
Tamires Carvalho dos Santos,Nadabe dos Santos Reis,Tatielle Pereira Silva,Fabiano de Paula Pereira Machado,Renata Cristina Ferereira Bonomo,Marcelo Franco 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.1
Prickly palm cactus husk was used as a solid-state fermentation support-substrate for production of the ligninolytic enzymes laccase, peroxide manganese, and lignin peroxidase by Aspergillus niger. Effects of water activity, temperature, and fermentation time on enzymatic production were evaluated using a central composite rotatable design. Response surface methodology revealed that maximum enzyme production was achieved at 73.38 h of fermentation, a water activity of 0.87 Aw, at 28.74oC for laccase, at 65.33 h, 0.89 Aw, and 28.96oC for lignin peroxidase, and at 70.44 h, 0.91 Aw, and 28.84oC for manganese peroxidase. Optimized enzyme production was 9,023.67 UI/L for laccase, 2,234.75 UI/L for lignin peroxidase, and 8,534.81 UI/L for manganese peroxidase. Thermostability and pH stability were observed for all enzymes. Enzymatic deactivation kinetic experiments indicated that enzymes remained active after freezing of crude extracts.