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- 저자 : Mao Tiantian (검색결과 2 건)
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The molecular mechanism of propionate-regulating gluconeogenesis in bovine hepatocytes
Pang Rui,Xiao Xiao,Mao Tiantian,Yu Jiajia,Huang Li,Xu Wei,Li Yu,Zhu Wen 아세아·태평양축산학회 2023 Animal Bioscience Vol.36 No.11
Objective: Cows that are nursing get around 80% of their glucose from liver gluconeogenesis. Propionate, a significant precursor of liver gluconeogenesis, can regulate the key genes involved in hepatic gluconeogenesis expression, but its precise effects on the activity of enzymes have not yet been fully elucidated. Therefore, the aim of this study was to investigate the effects of propionate on the activity, gene expression, and protein abundance of the key enzymes involved in the gluconeogenesis of dairy cow hepatocytes. Methods: The hepatocytes were cultured and treated with various concentrations of sodium propionate (0, 1.25, 2.50, 3.75, and 5.00 mM) for 12 h. Glucose content in the culture media was determined by an enzymatic coloring method. The activities of gluconeogenesis related enzymes were determined by enzyme linked immunosorbent assay kits, and the levels of gene expression and protein abundance of the enzymes were detected by real-time quantitative polymerase chain reaction and Western blot, respectively. Results: Propionate supplementation considerably increased the amount of glucose in the culture medium compared to the control (p<0.05); while there was no discernible difference among the various treatment concentrations (p>0.05). The activities of cytoplasmic phosphoenolpyruvate carboxylase (PEPCK1), mitochondrial phosphoenolpyruvate carboxylase (PEPCK2), pyruvate carboxylase (PC), and glucose-6-phosphatase (G6PC) were increased with the addition of 2.50 and 3.75 mM propionate; the gene expressions and protein abundances of PEPCK1, PEPCK2, PC, and G6PC were increased by 3.75 mM propionate addition. Conclusion: Propionate encouraged glucose synthesis in bovine hepatocytes, and 3.75 mM propionate directly increased the activities, gene expressions and protein abundances of PC, PEPCK1, PEPCK2, and G6PC in bovine hepatocytes, providing a theoretical basis of propionate-regulating gluconeogenesis in bovine hepatocytes.
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Harmonic resonance analysis and stability improvement for grid-connected inverters
Xie, Bao,Zhou, Lin,Liu, Tiantian,Mao, Mingxuan The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.1
The traditional dual-control-loop strategy is widely used in grid-connected inverters. However, due to uncertain grid conditions, a resonance phenomenon may arise in systems and grid current can be badly distorted. In addition, the systems themselves may be unstable. In this paper, an equivalent impedance model of a grid-connected inverter is established. Based on this, two concepts of circuit resonance and harmonic resonance are proposed. By using the Nyquist stability criterion, it is revealed that harmonic resonance is induced when system stability is decreased, and the harmonic amplification in the system is enhanced. Due to the fact that the dual-control-loop strategy has poor robustness against grid impedance variations, a linear quadratic regulator (LQR) based on full-state feedback is proposed in this paper. The design procedure for selecting the full-state feedback gain is presented. Finally, both simulation and experimental results are presented to verify the effectiveness of the proposed LQR controller.
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