Selective Catalytic Reduction system for reducing NOx emissions installed on a MAN B&W 6S35MC diesel engine

MAN B&W Diesel 한국마린엔지니어링학회 2001 International Conference on Marine Engineering Vol.- No.-

분류와 회귀나무분석에 관한 소고

임용빈,오만숙 한국품질경영학회 2002 품질경영학회지 Vol.30 No.1

대용량 자료를 다루는 데이터 마이닝에서 자료분석의 주요 도구인 분류나무와 희귀나무는 모형이 나무구조의 그림으로 시각적으로 표현되어서, 모형의 해석이 쉽다는 이점을 가지고 있다. 자료들의 약간의 변화 또는 흔들음(perturbation)이 나무구조나 예측치들의 커다란 변화를 초래할 수 있다는 점에서 나무예측치들이 불안정하다는 사실은 잘 알려져 있다. 불안정성을 개선하고 예측치의 정밀성을 높이기 위한 해결책의 하나는 다중 나무예측치를 사용하는 것이다. 이 때 치루어야할 대가는 예측치가 더 이상 나무구조로 표현되지 않아서 해석의 용이성을 잃는 것이다. 항암제나 에이즈 치료를 위한 백식개발등의 연구 개발의 처음 단계에서의 목표는 질병치료에 도움이 될 생물학적으로 효능있는 화합물 (potent molecules)들을 합성되지 않은 수십만 개의 화합물들 중에서 찾는 것이다. 데이터 베이스에 구축된 모든 화합물들의 합성과 검사에는 많은 비용과 시간이 소요되어 현실적으로 불가능하다. 따라서 소규모 양의 합성과 검사로 얻어진 자료를 가지고 희귀나무를 이용하여 반응치를 예측하여 검사되지 않은 화합물 중에서 효능이 있으리라 기대되는 화합물들을 선별하는 과정을 반복하는 축차적인 전략은 실용적인 가치가 매우 높은 체계적인 방법이다. The analysis of large data sets with hundreds of thousands observations and thousands of independent variables is a formidable computational task. A less parametric method, capable of identifying important independent variables and their interactions, is a tree structured approach to regression and classification. It gives a graphical and often illuminating way of looking at data in classification and regression problems. In this paper we have reviewed and summarized the methodology used to construct a tree, multiple trees and the sequential strategy for identifying active compounds in large chemical databases.

X-선 회절을 이용한 SS41불림재와 M.E.F.복합조직강의 ΔK 및 K_max 추정에 관한 연구

김득진,조용배,주원식,임만배 동아대학교 공과대학부설 생산기술연구소 1998 生産技術硏究所硏究論文集 Vol.3 No.1

This study verified the relationship between fracture mechanics parameters(ΔK, K_max) and X-ray parameters(σ_r, B) for normalized SS41 steel with homogeneous crystal structure and M.E.F. dual phase steel. The fatigue crack propagation test were carried out and X-ray diffraction technique according to crack length direction was applied to fatigue fractured surface. Residual stress, σ_r were independent on stress ratio(R=0.1, 0.5) by arrangement of ΔK and half-value breadth, B were independent by arrangement of K_max. The equation of σ_r-ΔK and B-K_max were established by the experimental datas. Therefore, fracture mechanics parameters could be estimated by the measurement of X-ray parameters.

Association of genetic variation in <i>FTO</i> with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians

Li, H.,Kilpelä,inen, T. O.,Liu, C.,Zhu, J.,Liu, Y.,Hu, C.,Yang, Z.,Zhang, W.,Bao, W.,Cha, S.,Wu, Y.,Yang, T.,Sekine, A.,Choi, B. Y.,Yajnik, C. S.,Zhou, D.,Takeuchi, F.,Yamamoto, K.,Chan, J. C.,Man Springer-Verlag 2012 Diabetologia Vol.55 No.4

<P><B>Aims/hypothesis</B></P><P><I>FTO</I> harbours the strongest known obesity-susceptibility locus in Europeans. While there is growing evidence for a role for <I>FTO</I> in obesity risk in Asians, its association with type 2 diabetes, independently of BMI, remains inconsistent. To test whether there is an association of the <I>FTO</I> locus with obesity and type 2 diabetes, we conducted a meta-analysis of 32 populations including 96,551 East and South Asians.</P><P><B>Methods</B></P><P>All studies published on the association between <I>FTO</I>-rs9939609 (or proxy [<I>r</I><SUP>2</SUP> > 0.98]) and BMI, obesity or type 2 diabetes in East or South Asians were invited. Each study group analysed their data according to a standardised analysis plan. Association with type 2 diabetes was also adjusted for BMI. Random-effects meta-analyses were performed to pool all effect sizes.</P><P><B>Results</B></P><P>The <I>FTO</I>-rs9939609 minor allele increased risk of obesity by 1.25-fold/allele (<I>p</I> = 9.0 × 10<SUP>−19</SUP>), overweight by 1.13-fold/allele (<I>p</I> = 1.0 × 10<SUP>−11</SUP>) and type 2 diabetes by 1.15-fold/allele (<I>p</I> = 5.5 × 10<SUP>−8</SUP>). The association with type 2 diabetes was attenuated after adjustment for BMI (OR 1.10-fold/allele, <I>p</I> = 6.6 × 10<SUP>−5</SUP>). The <I>FTO</I>-rs9939609 minor allele increased BMI by 0.26 kg/m<SUP>2</SUP> per allele (<I>p</I> = 2.8 × 10<SUP>−17</SUP>), WHR by 0.003/allele (<I>p</I> = 1.2 × 10<SUP>−6</SUP>), and body fat percentage by 0.31%/allele (<I>p</I> = 0.0005). Associations were similar using dominant models. While the minor allele is less common in East Asians (12–20%) than South Asians (30–33%), the effect of <I>FTO</I> variation on obesity-related traits and type 2 diabetes was similar in the two populations.</P><P><B>Conclusions/interpretation</B></P><P><I>FTO</I> is associated with increased risk of obesity and type 2 diabetes, with effect sizes similar in East and South Asians and similar to those observed in Europeans. Furthermore, <I>FTO</I> is also associated with type 2 diabetes independently of BMI.</P><P><B>Electronic supplementary material</B></P><P>The online version of this article (doi:10.1007/s00125-011-2370-7) contains peer-reviewed but unedited supplementary material, which is available to authorised users.</P>

Development of a High-Efficiency 4 <tex> $\pi\beta$</tex>(LS)– <tex> $\gamma$</tex> Coincidence System for Direct Measurements of Activity in Radioactive Decay

Lee, K B,Jong Man Lee,Tae Soon Park,Sang Han Lee IEEE 2010 IEEE transactions on nuclear science Vol.57 No.5

<P>We developed a new 4πβ (LS)-γ coincidence counting system to be used for radionuclide standardization. The liquid scintillation detector used in this system enables the easy preparation of sources without self-absorption. A special β- β coincidence technique is implemented to suppress large thermal and electronic noises, resulting in a higher coincidence efficiency and reduced uncertainty in the measurements of low-energy beta-emitting radionuclides. The system is commissioned with the activity measurement of <SUP>60</SUP>Co. The measured activity is derived with 90% efficiency for the β-ray detection.</P>

Dietary Calcium and 1,25-Dihydroxyvitamin D₃ Regulate Transcription of Calcium Transporter Genes in Calbindin-D9k Knockout Mice

KO, Sang-Hwan,LEE, Geun-Shik,VO, Thuy T. B.,JUNG, Eui-Man,CHOI, Kyung-Chul,CHEUNG, Ki-Wha,KIM, Jae Wha,PARK, Jong-Gil,OH, Goo Taeg,JEUNG, Eui-Bae Society for Reproduction and Development 2009 Journal of Reproduction and Development Vol.55 No.2

<P>The effect(s) of oral calcium and vitamin D<SUB>3</SUB> were examined on the expression of duodenal and renal active calcium transport genes, i.e., calbindin-D9k (<I>CaBP-9k</I>) and calbindin-D28k (<I>CaBP-28k</I>), transient receptor potential cation channels (<I>TRPV5</I> and <I>TRPV6</I>), Na<SUP>+</SUP>/Ca<SUP>2+</SUP> exchanger 1 (<I>NCX1</I>) and plasma membrane calcium ATPase 1b (<I>PMCA1b</I>), in <I>CaBP-9k</I> KO mice. Wild-type (WT) and KO mice were provided with calcium and vitamin D<SUB>3</SUB>-deficient diets for 10 weeks. The deficient diet significantly decreased body weights compared with the normal diet groups. The serum calcium concentration of the WT mice was decreased by the deficient diet but was unchanged in the KO mice. The deficient diet significantly increased duodenal transcription of <I>CaBP-9k</I> and <I>TRPV6</I> in the WT mice, but no alteration was observed in the KO mice. In the kidney, the deficient diet significantly increased renal transcripts of <I>CaBP-9k</I>, <I>TRPV6</I>, <I>PMCA1b</I>, <I>CaBP-28k</I> and <I>TRPV5</I> in the WT mice but did not alter calcium-relating genes in the KO mice. Two potential mediators of calcium-processing genes, vitamin D receptor (VDR) and parathyroid hormone receptor (PTHR), have been suggested to be useful for elucidating these differential regulations in the calcium-related genes of the KO mice. Expression of VDR was not significantly affected by diet or the KO mutation. Renal <I>PTHR</I> mRNA levels were reduced by the diet, and reduced expression was also seen in the KO mice given the normal diet. Taken together, these results suggest that the active calcium transporting genes in KO mice may have resistance to the deficiency diet of calcium and vitamin D<SUB>3</SUB>.</P>

Study on the Formation Mechanism of Hard Chrome Surface Morphology by Atomic Force Microscopy

B. K. Lee,Y. Choi,Man Kim,S. C. Kwon 한국표면공학회 2002 한국표면공학회 학술발표회 초록집 Vol.2002 No.-

Propulsion of LNG Carriers

MAN B&W 한국마린엔지니어링학회 2001 International Conference on Marine Engineering Vol.- No.-

Universal scheme for finite-probability perfect transfer of arbitrary multispin states through spin chains

Man, Z.X.,An, N.B.,Xia, Y.J.,Kim, J. Academic Press 2014 Annals of physics Vol.351 No.-

In combination with the theories of open system and quantum recovering measurement, we propose a quantum state transfer scheme using spin chains by performing two sequential operations: a projective measurement on the spins of 'environment' followed by suitably designed quantum recovering measurements on the spins of interest. The scheme allows perfect transfer of arbitrary multispin states through multiple parallel spin chains with finite probability. Our scheme is universal in the sense that it is state-independent and applicable to any model possessing spin-spin interactions. We also present possible methods to implement the required measurements taking into account the current experimental technologies. As applications, we consider two typical models for which the probabilities of perfect state transfer are found to be reasonably high at optimally chosen moments during the time evolution.

KAISO, a critical regulator of p53-mediated transcription of <i>CDKN1A</i> and apoptotic genes

Koh, Dong-In,Han, Dohyun,Ryu, Hoon,Choi, Won-Il,Jeon, Bu-Nam,Kim, Min-Kyeong,Kim, Youngsoo,Kim, Jin Young,Parry, Lee,Clarke, Alan R.,Reynolds, Albert B.,Hur, Man-Wook National Academy of Sciences 2014 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.111 No.42

<P><B>Significance</B></P><P>Transcription factor KAISO (POZ/BTB family protein, ZBTB33) expression is induced by genotoxic stress in a tumor suppressor p53-dependent manner. KAISO then interacts with p53 and the acetyltransferase p300 to modulate p300 acetylation of p53 and imposing upon p53 a “code,” i.e., acetylation at K320 and K382, and inhibition of acetylation at K381. This coded p53 shows increased DNA binding to p53 response elements in the promoters of <I>CDKN1A</I> (cyclin-dependent kinase inhibitor 1) and apoptosis genes, subsequently inducing cell cycle arrest and potent apoptosis. KAISO is a critical regulator of DNA damage responses in multiple cell types and carries out this function by regulating p53-mediated cell cycle arrest and apoptosis.</P><P>An unresolved issue in genotoxic stress response is identification of induced regulatory proteins and how these activate tumor suppressor p53 to determine appropriate cell responses. Transcription factor KAISO was previously described to repress transcription following binding to methylated DNA. In this study, we show that <I>KAISO</I> is induced by DNA damage in p53-expressing cells and then interacts with the p53–p300 complex to increase acetylation of p53 K320 and K382 residues, although decreasing K381 acetylation. Moreover, the p53 with this particular acetylation pattern shows increased DNA binding and potently induces cell cycle arrest and apoptosis by activating transcription of <I>CDKN1A</I> (cyclin-dependent kinase inhibitor 1) and various apoptotic genes. Analogously, in <I>Kaiso</I> KO mouse embryonic fibroblast cells, p53-to-promoter binding and up-regulation of <I>p21</I> and apoptosis gene expression is significantly compromised. KAISO may therefore be a critical regulator of p53-mediated cell cycle arrest and apoptosis in response to various genotoxic stresses in mammalian cells.</P>