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- 저자 : Manning, A. (검색결과 43,237 건)
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Informing direct neutron capture on tin isotopes near the N=82 shell closure
Manning, B.,Arbanas, G.,Cizewski, J. A.,Kozub, R. L.,Ahn, S.,Allmond, J. M.,Bardayan, D. W.,Chae, K. Y.,Chipps, K. A.,Howard, M. E.,Jones, K. L.,Liang, J. F.,Matos, M.,Nesaraja, C. D.,Nunes, F. M.,O'M American Physical Society 2019 Physical Review C Vol.99 No.4
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Manning, A.,Highland, H. M.,Gasser, J.,Sim, X.,Tukiainen, T.,Fontanillas, P. AMERICAN DIABETES ASSOCIATION INC 2017 Diabetes Vol.66 No.7
<P>To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together with an additional 390,225 variants from exome sequence in up to 39,339 normoglycemic individuals from five ancestry groups. We identified a novel association between the coding variant (p.Pro50Thr) in AKT2 and fasting plasma insulin (FI), a gene in which rare fully penetrant mutations are causal for monogenic glycemic disorders. The low-frequency allele is associated with a 12% increase in FI levels. This variant is present at 1.1% frequency in Finns but virtually absent in individuals from other ancestries. Carriers of the FI-increasing allele had increased 2-h insulin values, decreased insulin sensitivity, and increased risk of type 2 diabetes (odds ratio 1.05). In cellular studies, the AKT2-Thr50 protein exhibited a partial loss of function. We extend the allelic spectrum for coding variants in AKT2 associated with disorders of glucose homeostasis and demonstrate bidirectional effects of variants within the pleckstrin homology domain of AKT2.</P>
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Misrepresentation of the IPCC CO2 emission scenarios
Manning, M. R.,Edmonds, J.,Emori, S.,Grubler, A.,Hibbard, K.,Joos, F.,Kainuma, M.,Keeling, R. F.,Kram, T.,Manning, A. C.,Meinshausen, M.,Moss, R.,Nakicenovic, N.,Riahi, K.,Rose, S. K.,Smith, S.,Swart, Springer Science and Business Media LLC 2010 Nature geoscience Vol.3 No.6
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Settlement and Resettlement in Asia: Migration vs. Empire in History
MANNING, Patrick The Asian Association of World Historians 2015 The Asian review of world histories Vol.3 No.2
At its simplest, this essay provides a narrative of migration in Asia since the arrival of Homo sapiens some 70,000 years ago. More fully, it presents the case for conducting long-term, world-historical interpretation for Asia with attention to multiple perspectives, which has become increasingly central to global historical analysis. Following an introductory articulation of the benefits of long-term interpretation, the second section presents a balance of three perspectives-empire, exchange, and migration-as frameworks for interpreting the Asian past. The third section presents further detail on migration in long-term Asian history. The concluding section identifies four changes in patterns of migration during the past two centuries and emphasizes the underlying importance of cross-community migration in long-term human biological and social evolution.
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Paul Manning 한국외국어대학교 HK 세미오시스 연구센터 2021 Signs and Society Vol.9 No.2
Nineteenth-century Spiritualism was a watershed moment in which many of the keywords of our communication vocabulary—“medium,” “channel,” and “communication” itself—were first given fleshly and ghostly form in the spiritualist séance, which early on was likened to a “spiritual telegraph.” Throughout this period, newfangled ghosts and communication infrastructures (including the telegraph, but also the equally novel postal service) developed in tandem. This article explores three such boundary genres of communication between the living and the dead: how the séance converted the “spectral aphasia” of haunted houses into the domestic séance; how ghosts of loved ones dying far away across the “phantasmal empire” turned the ghost from an actor to a message, working in tandem with telegrams and letters in the “psychical ghost story”; and lastly, how the American spiritualist press created “spirit post offices” to publish communications from the dead alongside ordinary postal “correspondence” from the living.
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