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RISS 인기검색어
- 검색키워드
- 저자 : M. Kitano (검색결과 4 건)
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K. Iino,M. Kitano,M. Takeuchi,M. Matsuoka,M. Anpo 한국물리학회 2006 Current Applied Physics Vol.6 No.6
Advanced ion-beam techniques such as metal ion-implantation, ionized cluster beam (ICB) deposition and RF-magnetron sputtering (RF-MS) deposition were found to enable the development of unique titanium oxide photocatalyst materials which are able to absorb and work not only under UV but also visible or solar light irradiation. Thus prepared visible light-responsive TiO2 act as efficient photocatalysts for the NO decomposition reaction into N2 and O2 as well as the H2 and O2 evolution reaction from water.
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Chung, J.Y.,Kitano, H.,Takikita, M.,Cho, H.,Noh, K.H.,Kim, T.W.,Ylaya, K.,Hanaoka, J.,Fukuoka, J.,Hewitt, S.M. W. B. Saunders Co ; Centrum Philadelphia 2013 Human pathology Vol.44 No.4
Synaptonemal complex protein 3 is a marker for cell transformation that has prognostic significance in various cancers. However, the prognostic significance of synaptonemal complex protein 3 has not been studied in non-small cell lung cancer. To investigate the potential correlation between synaptonemal complex protein 3 and various clinicopathologic parameters, we assessed the expression of synaptonemal complex protein 3 in archival tumor tissues from 258 patients with non-small cell lung cancer by immunohistochemical staining. By immunofluorescence, synaptonemal complex protein 3 was detected in both the cytoplasmic and nuclear fractions of NCI-H1299 cell. In tumor samples, synaptonemal complex protein 3 is detected as cytoplasmic expression pattern and observed in 50 clinical samples (19.4%) by immunohistochemical staining. Synaptonemal complex protein 3 expression was correlated with T status (P = .008), lymph node metastasis (P = .010), tumor types (P = .019), and pleural invasion (P = .005). In multivariate analysis of patients with early stage disease, increased synaptonemal complex protein 3 expression predicted worse overall survival in early stage (stage I and II) with pT1 status (P = .041). These results suggest that positive synaptonemal complex protein 3 expression is a portent of poor outcome and may be a potential biomarker in the early stages of the non-small cell lung cancer for survival and may provide clues in the identification of patients for adjuvant therapy.
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Kim, B. W.,Cho, H.,Ylaya, K.,Kitano, H.,Chung, J.-Y.,Hewitt, S. M.,Kim, J.-H. INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH 2017 Anticancer research Vol.37 No.9
<P>Background/Aim: Bcl-2-like protein 11 (BIM) is a pro-apoptotic member of the Bcl-2 protein family. BIM elicits cell death by binding to pro-survival Bcl-2 proteins. Even though the association of BIM expression with cell death has been investigated, its clinical survival significance in cervical cancer has not. In the current study, the prognostic significance of BIM in cervical cancer was investigated. Patients and Methods: The study included normal cervical tissues (n=254), cervical intraepithelial neoplasia (CIN) tissues (n=275), and invasive cervical cancer (n=164). In order to identify BIM expression, immunohistochemistry (IHC) was performed, and IHC scoring by quantitative digital image analysis was determined. Then, the association of BIM with prognostic factors was investigated. Results: BIM expression was higher in cervical cancer than normal cervical tissues (p<0.001). Well and moderate differentiation indicated higher BIM expression than did poor differentiation (p=0.001). Also, BIM expression was high in radiation-sensitive cervical cancer relative to radiation-resistant cancer (p=0.049). High BIM expression showed better 5-year disease-free survival (DFS) and overall survival (OS) rates (p=0.049 and p=0.030, respectively) than did low expression. In a multivariate analysis, BIM was shown to be an independent risk factor for DFS and OS in cervical cancer, with hazard ratios of 0.22 (p=0.006) and 0.46 (p=0.046), respectively. Conclusion: BIM is associated with favorable prognostic markers for prediction of DFS and OS in cervical cancer. High BIM expression is a potential prognostic marker as well as a chemotherapeutic target for cervical cancer.</P>
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Han, Su Yeon,Ko, Aram,Kitano, Haruhisa,Choi, Chel Hun,Lee, Min-Sik,Seo, Jinho,Fukuoka, Junya,Kim, Soo-Youl,Hewitt, Stephen M.,Chung, Joon-Yong,Song, Jaewhan American Association for Cancer Research 2017 Cancer research Vol.77 No.2
<P>In elucidating how the tumor suppressor p14ARF is degraded, this study has implications for prognosis and treatment or p14ARF-expressing lung cancers.</P><P>The tumor suppressor function of p14ARF is regulated at a posttranslational level via mechanisms yet to be fully understood. Here, we report the identification of an unconventional p14ARF degradation pathway induced by the chaperone HSP90 in association with the E3 ubiquitin ligase C-terminus of HSP70-interacting protein (CHIP). The ternary complex of HSP90, CHIP, and p14ARF was required to induce the lysosomal degradation of p14ARF by an ubiquitination-independent but LAMP2A-dependent mechanism. Depletion of HSP90 or CHIP induced p14ARF-dependent senescence in human fibroblasts. Premature senescence observed in cells genetically deficient in CHIP was rescued in cells that were doubly deficient in CHIP and p14ARF. Notably, non–small cell lung cancer cells (NSCLC) positive for p14ARF were sensitive to treatment with the HSP90 inhibitor geldanamycin. Furthermore, overexpression of HSP90 and CHIP with a concomitant loss of p14ARF correlated with poor prognosis in patients with NSCLC. Our findings identify a relationship between p14ARF and its chaperones that suggest new therapeutic strategies in cancers that overexpress HSP90. <I>Cancer Res; 77(2); 343–54. ©2016 AACR</I>.</P>
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